rs1116657

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
T==0343 (10243/29792,GnomAD)
T==0329 (1647/5008,1000G)
T==0316 (1216/3854,ALSPAC)
T==0311 (1153/3708,TWINSUK)
chr5:113830440 (GRCh38.p7) (5q22.3)
AD
GWASdb2
1   publication(s)
See rs on genome
29 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.113830440T>C
GRCh37.p13 chr 5NC_000005.9:g.113166137T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.402C=0.598
1000GenomesAmericanSub694T=0.370C=0.630
1000GenomesEast AsianSub1008T=0.288C=0.712
1000GenomesEuropeSub1006T=0.306C=0.694
1000GenomesGlobalStudy-wide5008T=0.329C=0.671
1000GenomesSouth AsianSub978T=0.270C=0.730
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.316C=0.684
The Genome Aggregation DatabaseAfricanSub8680T=0.417C=0.583
The Genome Aggregation DatabaseAmericanSub834T=0.360C=0.640
The Genome Aggregation DatabaseEast AsianSub1600T=0.276C=0.724
The Genome Aggregation DatabaseEuropeSub18376T=0.316C=0.683
The Genome Aggregation DatabaseGlobalStudy-wide29792T=0.343C=0.656
The Genome Aggregation DatabaseOtherSub302T=0.220C=0.780
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.311C=0.689
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs11166570.000777alcohol dependence20201924

eQTL of rs1116657 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1116657 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr5113142615113142984E067-23153
chr5113142997113144136E067-22001
chr5113141967113142610E068-23527
chr5113141967113142610E069-23527
chr5113141967113142610E070-23527
chr5113142615113142984E070-23153
chr5113142997113144136E070-22001
chr5113144184113144245E070-21892
chr5113209970113210066E07043833
chr5113210836113211101E07044699
chr5113141967113142610E072-23527
chr5113142997113144136E072-22001
chr5113141967113142610E073-23527
chr5113142615113142984E073-23153
chr5113141967113142610E074-23527
chr5113142615113142984E074-23153
chr5113124550113124738E081-41399
chr5113141967113142610E081-23527
chr5113142615113142984E081-23153
chr5113142997113144136E081-22001
chr5113144184113144245E081-21892
chr5113144398113144669E081-21468
chr5113210836113211101E08144699
chr5113130675113131057E082-35080
chr5113141967113142610E082-23527
chr5113144184113144245E082-21892
chr5113144398113144669E082-21468
chr5113209970113210066E08243833
chr5113210836113211101E08244699