rs11256831

Homo sapiens
G>T
ASB13 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0194 (5831/29936,GnomAD)
T=0218 (6363/29118,TOPMED)
T=0323 (1619/5008,1000G)
T=0084 (323/3854,ALSPAC)
T=0081 (300/3708,TWINSUK)
chr10:5647095 (GRCh38.p7) (10p15.1)
AD
GWASdb2
1   publication(s)
See rs on genome
59 Enhancers around
27 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 10NC_000010.11:g.5647095G>T
GRCh37.p13 chr 10NC_000010.10:g.5689058G>T

Gene: ASB13, ankyrin repeat and SOCS box containing 13(minus strand)

Molecule type Change Amino acid[Codon] SO Term
ASB13 transcript variant 1NM_024701.3:c.N/AIntron Variant
ASB13 transcript variant 2NR_024581.1:n.N/AIntron Variant
ASB13 transcript variant 3NR_037164.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.658T=0.342
1000GenomesAmericanSub694G=0.560T=0.440
1000GenomesEast AsianSub1008G=0.498T=0.502
1000GenomesEuropeSub1006G=0.889T=0.111
1000GenomesGlobalStudy-wide5008G=0.677T=0.323
1000GenomesSouth AsianSub978G=0.750T=0.250
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.916T=0.084
The Genome Aggregation DatabaseAfricanSub8698G=0.674T=0.326
The Genome Aggregation DatabaseAmericanSub838G=0.560T=0.440
The Genome Aggregation DatabaseEast AsianSub1614G=0.476T=0.524
The Genome Aggregation DatabaseEuropeSub18484G=0.905T=0.094
The Genome Aggregation DatabaseGlobalStudy-wide29936G=0.805T=0.194
The Genome Aggregation DatabaseOtherSub302G=0.860T=0.140
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.781T=0.218
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.919T=0.081
PMID Title Author Journal
21703634A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.Wang KSJ Psychiatr Res

P-Value

SNP ID p-value Traits Study
rs112568317.15E-05alcohol dependence21703634

eQTL of rs11256831 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs11256831 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr1057290565729110E06739998
chr1057355625735659E06746504
chr1057357325735810E06746674
chr1057358655735919E06746807
chr1057359745736079E06746916
chr1056606795661293E068-27765
chr1057016625702595E06812604
chr1057064485706587E06817390
chr1057071045707162E06818046
chr1057072455707377E06818187
chr1057338325734055E06844774
chr1057341335734183E06845075
chr1057363115736383E06847253
chr1056645605665620E069-23438
chr1057355625735659E06946504
chr1057357325735810E06946674
chr1057358655735919E06946807
chr1057359745736079E06946916
chr1057363115736383E06947253
chr1057338325734055E07044774
chr1057341335734183E07045075
chr1057016625702595E07112604
chr1057071045707162E07118046
chr1057072455707377E07118187
chr1057355625735659E07146504
chr1057357325735810E07146674
chr1057358655735919E07146807
chr1057359745736079E07146916
chr1057363115736383E07147253
chr1057368945737016E07147836
chr1056717605672392E072-16666
chr1057355625735659E07246504
chr1057357325735810E07246674
chr1057358655735919E07246807
chr1057359745736079E07246916
chr1057363115736383E07247253
chr1056557795656805E073-32253
chr1056645605665620E073-23438
chr1057028545702921E07313796
chr1057030215703081E07313963
chr1057071045707162E07318046
chr1057072455707377E07318187
chr1057355625735659E07346504
chr1057357325735810E07346674
chr1057358655735919E07346807
chr1057359745736079E07346916
chr1056645605665620E074-23438
chr1056736415673702E074-15356
chr1057338325734055E07444774
chr1057341335734183E07445075
chr1057355625735659E07446504
chr1057357325735810E07446674
chr1057358655735919E07446807
chr1057359745736079E07446916
chr1057363115736383E07447253
chr1057368945737016E07447836
chr1057072455707377E08118187
chr1057338325734055E08144774
chr1057341335734183E08145075









Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr1057074235709215E06718365
chr1057260205728188E06736962
chr1057342025735417E06745144
chr1057074235709215E06818365
chr1057260205728188E06836962
chr1057342025735417E06845144
chr1057074235709215E06918365
chr1057260205728188E06936962
chr1057342025735417E06945144
chr1057074235709215E07018365
chr1057260205728188E07036962
chr1057074235709215E07118365
chr1057260205728188E07136962
chr1057342025735417E07145144
chr1057074235709215E07218365
chr1057260205728188E07236962
chr1057342025735417E07245144
chr1057074235709215E07318365
chr1057260205728188E07336962
chr1057342025735417E07345144
chr1057074235709215E07418365
chr1057260205728188E07436962
chr1057342025735417E07445144
chr1057074235709215E08118365
chr1057260205728188E08136962
chr1057074235709215E08218365
chr1057260205728188E08236962