rs1153459

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0459 (13678/29780,GnomAD)
C=0422 (12309/29118,TOPMED)
C=0346 (1734/5008,1000G)
T==0497 (1914/3854,ALSPAC)
T==0490 (1818/3708,TWINSUK)
chr3:3116801 (GRCh38.p7) (3p26.2)
AD
GWASdb2
2   publication(s)
See rs on genome
19 Enhancers around
10 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.3116801T>C
GRCh37.p13 chr 3NC_000003.11:g.3158485T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.698C=0.302
1000GenomesAmericanSub694T=0.560C=0.440
1000GenomesEast AsianSub1008T=0.789C=0.211
1000GenomesEuropeSub1006T=0.480C=0.520
1000GenomesGlobalStudy-wide5008T=0.654C=0.346
1000GenomesSouth AsianSub978T=0.700C=0.300
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.497C=0.503
The Genome Aggregation DatabaseAfricanSub8638T=0.674C=0.326
The Genome Aggregation DatabaseAmericanSub814T=0.550C=0.450
The Genome Aggregation DatabaseEast AsianSub1614T=0.815C=0.185
The Genome Aggregation DatabaseEuropeSub18412T=0.454C=0.545
The Genome Aggregation DatabaseGlobalStudy-wide29780T=0.540C=0.459
The Genome Aggregation DatabaseOtherSub302T=0.490C=0.510
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.577C=0.422
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.490C=0.510
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res
19223858Genomewide linkage scan of schizophrenia in a large multicenter pedigree sample using single nucleotide polymorphisms.Holmans PAMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs11534590.00054alcohol dependence20201924

eQTL of rs1153459 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1153459 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr331676103167650E0679125
chr331700863170207E06711601
chr331705103170623E06712025
chr331706583170765E06712173
chr331967283196808E06738243
chr331848173184939E06826332
chr331674463167500E0718961
chr331676103167650E0719125
chr331706583170765E07112173
chr331676103167650E0729125
chr331848173184939E07226332
chr332044873204527E07246002
chr331768123177048E07318327
chr331676103167650E0749125
chr331903703190513E07431885
chr331676103167650E0819125
chr331700863170207E08111601
chr331674463167500E0828961
chr331676103167650E0829125








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr331679473169698E0679462
chr331679473169698E0689462
chr331679473169698E0699462
chr331679473169698E0709462
chr331679473169698E0719462
chr331679473169698E0729462
chr331679473169698E0739462
chr331679473169698E0749462
chr331679473169698E0819462
chr331679473169698E0829462