rs115368721

Homo sapiens
G>A
APBB2 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0020 (619/29900,GnomAD)
A=0032 (946/29118,TOPMED)
A=0023 (113/5008,1000G)
A=0001 (2/3854,ALSPAC)
A=0000 (1/3708,TWINSUK)
chr4:41054822 (GRCh38.p7) (4p14)
OD
GWASdb2
1   publication(s)
See rs on genome
221 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.41054822G>A
GRCh37.p13 chr 4NC_000004.11:g.41056839G>A
APBB2 RefSeqGeneNG_013337.1:g.164797C>T

Gene: APBB2, amyloid beta precursor protein binding family B member 2(minus strand)

Molecule type Change Amino acid[Codon] SO Term
APBB2 transcript variant 2NM_001166050.1:c.N/AIntron Variant
APBB2 transcript variant 1NM_004307.1:c.N/AIntron Variant
APBB2 transcript variant 3NM_173075.4:c.N/AIntron Variant
APBB2 transcript variant 4NM_001166051.1:c.N/AGenic Upstream Transcript Variant
APBB2 transcript variant 5NM_001166052.1:c.N/AGenic Upstream Transcript Variant
APBB2 transcript variant 6NM_001166053.1:c.N/AGenic Upstream Transcript Variant
APBB2 transcript variant 7NM_001166054.1:c.N/AGenic Upstream Transcript Variant
APBB2 transcript variant X23XM_005248101.3:c.N/AIntron Variant
APBB2 transcript variant X1XM_006714005.3:c.N/AIntron Variant
APBB2 transcript variant X3XM_006714007.3:c.N/AIntron Variant
APBB2 transcript variant X5XM_006714008.3:c.N/AIntron Variant
APBB2 transcript variant X6XM_006714009.3:c.N/AIntron Variant
APBB2 transcript variant X7XM_006714010.3:c.N/AIntron Variant
APBB2 transcript variant X15XM_006714011.3:c.N/AIntron Variant
APBB2 transcript variant X18XM_006714012.3:c.N/AIntron Variant
APBB2 transcript variant X4XM_011513686.2:c.N/AIntron Variant
APBB2 transcript variant X20XM_011513687.2:c.N/AIntron Variant
APBB2 transcript variant X28XM_011513688.2:c.N/AIntron Variant
APBB2 transcript variant X2XM_017008142.1:c.N/AIntron Variant
APBB2 transcript variant X8XM_017008143.1:c.N/AIntron Variant
APBB2 transcript variant X9XM_017008144.1:c.N/AIntron Variant
APBB2 transcript variant X10XM_017008145.1:c.N/AIntron Variant
APBB2 transcript variant X11XM_017008146.1:c.N/AIntron Variant
APBB2 transcript variant X12XM_017008147.1:c.N/AIntron Variant
APBB2 transcript variant X13XM_017008148.1:c.N/AIntron Variant
APBB2 transcript variant X14XM_017008149.1:c.N/AIntron Variant
APBB2 transcript variant X16XM_017008150.1:c.N/AIntron Variant
APBB2 transcript variant X17XM_017008151.1:c.N/AIntron Variant
APBB2 transcript variant X19XM_017008152.1:c.N/AIntron Variant
APBB2 transcript variant X21XM_017008153.1:c.N/AIntron Variant
APBB2 transcript variant X22XM_017008154.1:c.N/AIntron Variant
APBB2 transcript variant X24XM_017008155.1:c.N/AIntron Variant
APBB2 transcript variant X25XM_017008156.1:c.N/AIntron Variant
APBB2 transcript variant X26XM_017008157.1:c.N/AIntron Variant
APBB2 transcript variant X27XM_017008158.1:c.N/AIntron Variant
APBB2 transcript variant X29XM_017008159.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.920A=0.080
1000GenomesAmericanSub694G=0.990A=0.010
1000GenomesEast AsianSub1008G=1.000A=0.000
1000GenomesEuropeSub1006G=0.998A=0.002
1000GenomesGlobalStudy-wide5008G=0.977A=0.023
1000GenomesSouth AsianSub978G=1.000A=0.000
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.999A=0.001
The Genome Aggregation DatabaseAfricanSub8684G=0.930A=0.070
The Genome Aggregation DatabaseAmericanSub838G=0.990A=0.010
The Genome Aggregation DatabaseEast AsianSub1616G=1.000A=0.000
The Genome Aggregation DatabaseEuropeSub18460G=0.999A=0.000
The Genome Aggregation DatabaseGlobalStudy-wide29900G=0.979A=0.020
The Genome Aggregation DatabaseOtherSub302G=1.000A=0.000
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.967A=0.032
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=1.000A=0.000
PMID Title Author Journal
24143882Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways.Gelernter JBiol Psychiatry

P-Value

SNP ID p-value Traits Study
rs1153687211.92E-08Opioid sensitivity24143882

eQTL of rs115368721 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs115368721 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr44101673241017646E067-39193
chr44106242941063383E0675590
chr44106342341063477E0676584
chr44106359841063812E0676759
chr44106387441063977E0677035
chr44106756841067745E06710729
chr44107191141072006E06715072
chr44107202241072152E06715183
chr44107396841074605E06717129
chr44107579441076009E06718955
chr44107630041076494E06719461
chr44107792041078176E06721081
chr44107826841078384E06721429
chr44108053041080616E06723691
chr44108097241081022E06724133
chr44108190941082666E06725070
chr44108304141083148E06726202
chr44108404641084149E06727207
chr44110021441100397E06743375
chr44110045341100631E06743614
chr44110071041100846E06743871
chr44110419741104249E06747358
chr44110441241104452E06747573
chr44110454241104931E06747703
chr44110584641105929E06749007
chr44110621141106411E06749372
chr44105257941052654E068-4185
chr44105283041053416E068-3423
chr44105356641053635E068-3204
chr44105446541054703E068-2136
chr44106242941063383E0685590
chr44106342341063477E0686584
chr44106359841063812E0686759
chr44106387441063977E0687035
chr44106400441064161E0687165
chr44106489741064985E0688058
chr44106756841067745E06810729
chr44107129541071644E06814456
chr44107191141072006E06815072
chr44107396841074605E06817129
chr44107792041078176E06821081
chr44107826841078384E06821429
chr44108097241081022E06824133
chr44108304141083148E06826202
chr44108404641084149E06827207
chr44110021441100397E06843375
chr44110045341100631E06843614
chr44110071041100846E06843871
chr44110454241104931E06847703
chr44110516541105215E06848326
chr44101673241017646E069-39193
chr44104149041041693E069-15146
chr44105257941052654E069-4185
chr44105283041053416E069-3423
chr44105356641053635E069-3204
chr44106242941063383E0695590
chr44106342341063477E0696584
chr44106359841063812E0696759
chr44106387441063977E0697035
chr44106400441064161E0697165
chr44106489741064985E0698058
chr44106686641066906E06910027
chr44106756841067745E06910729
chr44106952441069654E06912685
chr44107129541071644E06914456
chr44107191141072006E06915072
chr44107202241072152E06915183
chr44107396841074605E06917129
chr44107579441076009E06918955
chr44107689741077146E06920058
chr44107792041078176E06921081
chr44107826841078384E06921429
chr44107907941079398E06922240
chr44107980541079903E06922966
chr44108097241081022E06924133
chr44108190941082666E06925070
chr44108304141083148E06926202
chr44108404641084149E06927207
chr44109434541094454E06937506
chr44109527441095347E06938435
chr44110021441100397E06943375
chr44110045341100631E06943614
chr44110071041100846E06943871
chr44110419741104249E06947358
chr44110441241104452E06947573
chr44110454241104931E06947703
chr44106670541066857E0709866
chr44106686641066906E07010027
chr44106756841067745E07010729
chr44103048441030819E071-26020
chr44103128041031349E071-25490
chr44103140241031465E071-25374
chr44104051241040630E071-16209
chr44104963141049693E071-7146
chr44105221041052523E071-4316
chr44105257941052654E071-4185
chr44105283041053416E071-3423
chr44105356641053635E071-3204
chr44105955941059926E0712720
chr44106003841060131E0713199
chr44106342341063477E0716584
chr44106359841063812E0716759
chr44106387441063977E0717035
chr44106400441064161E0717165
chr44106489741064985E0718058
chr44106571441065782E0718875
chr44106756841067745E07110729
chr44106952441069654E07112685
chr44107129541071644E07114456
chr44107191141072006E07115072
chr44107202241072152E07115183
chr44107238341072495E07115544
chr44107396841074605E07117129
chr44107792041078176E07121081
chr44107826841078384E07121429
chr44107907941079398E07122240
chr44107980541079903E07122966
chr44108053041080616E07123691
chr44108097241081022E07124133
chr44108304141083148E07126202
chr44108404641084149E07127207
chr44109434541094454E07137506
chr44110021441100397E07143375
chr44110045341100631E07143614
chr44110071041100846E07143871
chr44110419741104249E07147358
chr44110441241104452E07147573
chr44110454241104931E07147703
chr44103140241031465E072-25374
chr44104963141049693E072-7146
chr44105356641053635E072-3204
chr44106242941063383E0725590
chr44106342341063477E0726584
chr44106359841063812E0726759
chr44106387441063977E0727035
chr44106400441064161E0727165
chr44106489741064985E0728058
chr44106756841067745E07210729
chr44107129541071644E07214456
chr44107191141072006E07215072
chr44107202241072152E07215183
chr44107238341072495E07215544
chr44107302141073203E07216182
chr44107396841074605E07217129
chr44107579441076009E07218955
chr44107630041076494E07219461
chr44107826841078384E07221429
chr44107907941079398E07222240
chr44107980541079903E07222966
chr44108053041080616E07223691
chr44108097241081022E07224133
chr44108190941082666E07225070
chr44108304141083148E07226202
chr44108404641084149E07227207
chr44110021441100397E07243375
chr44110045341100631E07243614
chr44110071041100846E07243871
chr44110441241104452E07247573
chr44110454241104931E07247703
chr44105283041053416E073-3423
chr44105356641053635E073-3204
chr44105955941059926E0732720
chr44106003841060131E0733199
chr44106242941063383E0735590
chr44106342341063477E0736584
chr44106359841063812E0736759
chr44106387441063977E0737035
chr44106400441064161E0737165
chr44106648441066650E0739645
chr44106670541066857E0739866
chr44106686641066906E07310027
chr44106756841067745E07310729
chr44107396841074605E07317129
chr44107792041078176E07321081
chr44107826841078384E07321429
chr44107980541079903E07322966
chr44108304141083148E07326202
chr44109527441095347E07338435
chr44110454241104931E07347703
chr44101139041011814E074-45025
chr44101673241017646E074-39193
chr44104051241040630E074-16209
chr44104963141049693E074-7146
chr44105283041053416E074-3423
chr44105356641053635E074-3204
chr44105446541054703E074-2136
chr44106242941063383E0745590
chr44106342341063477E0746584
chr44106359841063812E0746759
chr44106387441063977E0747035
chr44106400441064161E0747165
chr44106756841067745E07410729
chr44106952441069654E07412685
chr44107129541071644E07414456
chr44107191141072006E07415072
chr44107202241072152E07415183
chr44107302141073203E07416182
chr44107396841074605E07417129
chr44107579441076009E07418955
chr44107792041078176E07421081
chr44107826841078384E07421429
chr44107907941079398E07422240
chr44107980541079903E07422966
chr44108053041080616E07423691
chr44108097241081022E07424133
chr44108190941082666E07425070
chr44108304141083148E07426202
chr44108404641084149E07427207
chr44109434541094454E07437506
chr44109527441095347E07438435
chr44110021441100397E07443375
chr44110045341100631E07443614
chr44110071041100846E07443871
chr44110419741104249E07447358
chr44110441241104452E07447573
chr44110454241104931E07447703
chr44110516541105215E07448326
chr44110527541105344E07448436
chr44107191141072006E08115072
chr44107202241072152E08115183
chr44107689741077146E08120058