rs11577033

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0069 (2094/29968,GnomAD)
C=0058 (1694/29118,TOPMED)
C=0064 (323/5008,1000G)
C=0084 (323/3854,ALSPAC)
C=0071 (262/3708,TWINSUK)
chr1:23711741 (GRCh38.p7) (1p36.11)
AD
GWASdb2
1   publication(s)
See rs on genome
110 Enhancers around
20 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 1NC_000001.11:g.23711741T>C
GRCh37.p13 chr 1NC_000001.10:g.24038231T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.940C=0.060
1000GenomesAmericanSub694T=0.960C=0.040
1000GenomesEast AsianSub1008T=0.975C=0.025
1000GenomesEuropeSub1006T=0.922C=0.078
1000GenomesGlobalStudy-wide5008T=0.936C=0.064
1000GenomesSouth AsianSub978T=0.890C=0.110
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.916C=0.084
The Genome Aggregation DatabaseAfricanSub8720T=0.940C=0.060
The Genome Aggregation DatabaseAmericanSub838T=0.960C=0.040
The Genome Aggregation DatabaseEast AsianSub1622T=0.995C=0.005
The Genome Aggregation DatabaseEuropeSub18486T=0.918C=0.081
The Genome Aggregation DatabaseGlobalStudy-wide29968T=0.930C=0.069
The Genome Aggregation DatabaseOtherSub302T=0.890C=0.110
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.941C=0.058
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.929C=0.071
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs115770330.00041alcohol dependence20201924
rs115770330.00057alcohol dependence(Early Onset)20201924

eQTL of rs11577033 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs11577033 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr12401996024020070E067-18161
chr12402019924020301E067-17930
chr12405329924053421E06715068
chr12405348024053530E06715249
chr12405379024054358E06715559
chr12406865924068739E06730428
chr12407204124072488E06733810
chr12407777824078057E06739547
chr12407806924078245E06739838
chr12408327224083438E06745041
chr12408611624086230E06747885
chr12408745524087568E06749224
chr12408776324087828E06749532
chr12408794324088068E06749712
chr12401966124019783E068-18448
chr12401996024020070E068-18161
chr12402019924020301E068-17930
chr12402049424020537E068-17694
chr12402101824021111E068-17120
chr12402121024021260E068-16971
chr12402131024021364E068-16867
chr12402211624022321E068-15910
chr12402296724023146E068-15085
chr12408571224086068E06847481
chr12408611624086230E06847885
chr12408745524087568E06849224
chr12408776324087828E06849532
chr12408794324088068E06849712
chr12408806924088119E06849838
chr12401996024020070E069-18161
chr12402019924020301E069-17930
chr12402049424020537E069-17694
chr12402101824021111E069-17120
chr12402121024021260E069-16971
chr12402131024021364E069-16867
chr12402211624022321E069-15910
chr12402296724023146E069-15085
chr12404600124046193E0697770
chr12405329924053421E06915068
chr12405348024053530E06915249
chr12405379024054358E06915559
chr12407204124072488E06933810
chr12407434024074380E06936109
chr12407452024074612E06936289
chr12407464724074753E06936416
chr12408327224083438E06945041
chr12408571224086068E06947481
chr12408611624086230E06947885
chr12408745524087568E06949224
chr12408776324087828E06949532
chr12401996024020070E070-18161
chr12402019924020301E070-17930
chr12402049424020537E070-17694
chr12402101824021111E070-17120
chr12402121024021260E070-16971
chr12402131024021364E070-16867
chr12402211624022321E070-15910
chr12402296724023146E070-15085
chr12407204124072488E07033810
chr12408571224086068E07047481
chr12408611624086230E07047885
chr12401996024020070E071-18161
chr12402019924020301E071-17930
chr12402049424020537E071-17694
chr12402101824021111E071-17120
chr12402121024021260E071-16971
chr12402131024021364E071-16867
chr12402211624022321E071-15910
chr12404600124046193E0717770
chr12405329924053421E07115068
chr12405348024053530E07115249
chr12405379024054358E07115559
chr12408571224086068E07147481
chr12408611624086230E07147885
chr12408745524087568E07149224
chr12408776324087828E07149532
chr12408794324088068E07149712
chr12408806924088119E07149838
chr12401996024020070E072-18161
chr12405379024054358E07215559
chr12408571224086068E07247481
chr12408611624086230E07247885
chr12408745524087568E07249224
chr12401966124019783E073-18448
chr12401996024020070E073-18161
chr12402019924020301E073-17930
chr12402049424020537E073-17694
chr12402101824021111E073-17120
chr12405329924053421E07315068
chr12405348024053530E07315249
chr12405379024054358E07315559
chr12407777824078057E07339547
chr12408571224086068E07347481
chr12408611624086230E07347885
chr12408745524087568E07349224
chr12401966124019783E074-18448
chr12401996024020070E074-18161
chr12402019924020301E074-17930
chr12405329924053421E07415068
chr12405348024053530E07415249
chr12405379024054358E07415559
chr12408571224086068E07447481
chr12408611624086230E07447885
chr12407204124072488E08133810
chr12402019924020301E082-17930
chr12402049424020537E082-17694
chr12402101824021111E082-17120
chr12402121024021260E082-16971
chr12402131024021364E082-16867
chr12407204124072488E08233810










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr12401794024018931E067-19300
chr12406898924070961E06730758
chr12401794024018931E068-19300
chr12406898924070961E06830758
chr12401794024018931E069-19300
chr12406898924070961E06930758
chr12401794024018931E070-19300
chr12406898924070961E07030758
chr12401794024018931E071-19300
chr12406898924070961E07130758
chr12401794024018931E072-19300
chr12406898924070961E07230758
chr12401794024018931E073-19300
chr12406898924070961E07330758
chr12401794024018931E074-19300
chr12406898924070961E07430758
chr12401794024018931E081-19300
chr12406898924070961E08130758
chr12401794024018931E082-19300
chr12406898924070961E08230758