rs11581510

Organism: Homo sapiens

Alleles: G>A / G>T

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A=0021 (644/29994,GnomAD)
A=0025 (748/29118,TOPMED)
A=0035 (174/5008,1000G)
A=0037 (144/3854,ALSPAC)
A=0035 (131/3708,TWINSUK)

Position: chr1:115129524 (GRCh38.p7) (1p13.2)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 431 Enhancers around

Promoter: 26 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 1	NC_000001.11:g.115129524G>A
GRCh38.p7 chr 1	NC_000001.11:g.115129524G>T
GRCh37.p13 chr 1	NC_000001.10:g.115672145G>A
GRCh37.p13 chr 1	NC_000001.10:g.115672145G>T

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.994	A=0.006
1000Genomes	American	Sub	694	G=0.960	A=0.040
1000Genomes	East Asian	Sub	1008	G=0.963	A=0.037
1000Genomes	Europe	Sub	1006	G=0.960	A=0.040
1000Genomes	Global	Study-wide	5008	G=0.965	A=0.035
1000Genomes	South Asian	Sub	978	G=0.940	A=0.060
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.963	A=0.037
The Genome Aggregation Database	African	Sub	8730	G=0.992	A=0.008
The Genome Aggregation Database	American	Sub	838	G=0.980	A=0.020
The Genome Aggregation Database	East Asian	Sub	1622	G=0.964	A=0.036
The Genome Aggregation Database	Europe	Sub	18502	G=0.974	A=0.025
The Genome Aggregation Database	Global	Study-wide	29994	G=0.978	A=0.021
The Genome Aggregation Database	Other	Sub	302	G=0.940	A=0.060
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.974	A=0.025
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.965	A=0.035

PMID	Title	Author	Journal
20201924	Genome-wide association study of alcohol dependence implicates a region on chromosome 11.	Edenberg HJ	Alcohol Clin Exp Res

P-Value

SNP ID	p-value	Traits	Study
rs11581510	0.00057	alcohol dependence(early age of onset)	20201924
rs11581510	0.00084	alcohol dependence	20201924

eQTL of rs11581510 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs11581510 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr1	45060260	45060328	E067	-49825
chr1	45060657	45060723	E067	-49430
chr1	45060747	45061219	E067	-48934
chr1	45068548	45068639	E067	-41514
chr1	45068653	45068721	E067	-41432
chr1	45068905	45068976	E067	-41177
chr1	45069057	45069115	E067	-41038
chr1	45075512	45075705	E067	-34448
chr1	45075854	45076044	E067	-34109
chr1	45082275	45082372	E067	-27781
chr1	45083465	45083583	E067	-26570
chr1	45083861	45083927	E067	-26226
chr1	45084250	45084492	E067	-25661
chr1	45096617	45096674	E067	-13479
chr1	45096764	45096916	E067	-13237
chr1	45098812	45098898	E067	-11255
chr1	45099316	45099366	E067	-10787
chr1	45099549	45099653	E067	-10500
chr1	45099684	45099734	E067	-10419
chr1	45099921	45099968	E067	-10185
chr1	45100351	45100577	E067	-9576
chr1	45107517	45107568	E067	-2585
chr1	45108071	45108156	E067	-1997
chr1	45108554	45108685	E067	-1468
chr1	45108710	45108847	E067	-1306
chr1	45109296	45109349	E067	-804
chr1	45109585	45109639	E067	-514
chr1	45109726	45109894	E067	-259
chr1	45110625	45110726	E067	472
chr1	45110834	45110899	E067	681
chr1	45111130	45111775	E067	977
chr1	45111850	45111956	E067	1697
chr1	45111998	45112215	E067	1845
chr1	45112221	45112374	E067	2068
chr1	45112468	45112680	E067	2315
chr1	45114993	45115043	E067	4840
chr1	45115847	45116470	E067	5694
chr1	45118174	45118962	E067	8021
chr1	45119024	45119149	E067	8871
chr1	45125866	45126295	E067	15713
chr1	45128090	45128250	E067	17937
chr1	45128437	45128689	E067	18284
chr1	45136838	45136901	E067	26685
chr1	45137778	45138440	E067	27625
chr1	45138478	45138719	E067	28325
chr1	45060260	45060328	E068	-49825
chr1	45060657	45060723	E068	-49430
chr1	45060747	45061219	E068	-48934
chr1	45062646	45062787	E068	-47366
chr1	45063208	45063258	E068	-46895
chr1	45063295	45063345	E068	-46808
chr1	45068548	45068639	E068	-41514
chr1	45068653	45068721	E068	-41432
chr1	45068905	45068976	E068	-41177
chr1	45069057	45069115	E068	-41038
chr1	45069442	45069791	E068	-40362
chr1	45069916	45070100	E068	-40053
chr1	45074978	45075111	E068	-35042
chr1	45083465	45083583	E068	-26570
chr1	45083861	45083927	E068	-26226
chr1	45084250	45084492	E068	-25661
chr1	45085788	45085868	E068	-24285
chr1	45086083	45086138	E068	-24015
chr1	45087508	45087942	E068	-22211
chr1	45096309	45096411	E068	-13742
chr1	45096617	45096674	E068	-13479
chr1	45096764	45096916	E068	-13237
chr1	45101657	45101722	E068	-8431
chr1	45105940	45106133	E068	-4020
chr1	45107517	45107568	E068	-2585
chr1	45108071	45108156	E068	-1997
chr1	45108554	45108685	E068	-1468
chr1	45108710	45108847	E068	-1306
chr1	45109296	45109349	E068	-804
chr1	45109585	45109639	E068	-514
chr1	45109726	45109894	E068	-259
chr1	45110625	45110726	E068	472
chr1	45110834	45110899	E068	681
chr1	45111130	45111775	E068	977
chr1	45111850	45111956	E068	1697
chr1	45111998	45112215	E068	1845
chr1	45115847	45116470	E068	5694
chr1	45118174	45118962	E068	8021
chr1	45127443	45128025	E068	17290
chr1	45128090	45128250	E068	17937
chr1	45128437	45128689	E068	18284
chr1	45136838	45136901	E068	26685
chr1	45137778	45138440	E068	27625
chr1	45138478	45138719	E068	28325
chr1	45142679	45142759	E068	32526
chr1	45142769	45143222	E068	32616
chr1	45060260	45060328	E069	-49825
chr1	45060657	45060723	E069	-49430
chr1	45060747	45061219	E069	-48934
chr1	45062352	45062402	E069	-47751
chr1	45062646	45062787	E069	-47366
chr1	45068548	45068639	E069	-41514
chr1	45068653	45068721	E069	-41432
chr1	45068905	45068976	E069	-41177
chr1	45069057	45069115	E069	-41038
chr1	45069442	45069791	E069	-40362
chr1	45069916	45070100	E069	-40053
chr1	45074978	45075111	E069	-35042
chr1	45075189	45075509	E069	-34644
chr1	45075512	45075705	E069	-34448
chr1	45075854	45076044	E069	-34109
chr1	45076076	45076397	E069	-33756
chr1	45076555	45076743	E069	-33410
chr1	45079820	45079904	E069	-30249
chr1	45081604	45081675	E069	-28478
chr1	45081746	45081825	E069	-28328
chr1	45082275	45082372	E069	-27781
chr1	45083465	45083583	E069	-26570
chr1	45083861	45083927	E069	-26226
chr1	45084250	45084492	E069	-25661
chr1	45084822	45085543	E069	-24610
chr1	45085788	45085868	E069	-24285
chr1	45086083	45086138	E069	-24015
chr1	45086344	45086424	E069	-23729
chr1	45087508	45087942	E069	-22211
chr1	45096309	45096411	E069	-13742
chr1	45096617	45096674	E069	-13479
chr1	45096764	45096916	E069	-13237
chr1	45098812	45098898	E069	-11255
chr1	45099316	45099366	E069	-10787
chr1	45099549	45099653	E069	-10500
chr1	45099684	45099734	E069	-10419
chr1	45099921	45099968	E069	-10185
chr1	45100351	45100577	E069	-9576
chr1	45107517	45107568	E069	-2585
chr1	45108071	45108156	E069	-1997
chr1	45108554	45108685	E069	-1468
chr1	45108710	45108847	E069	-1306
chr1	45109296	45109349	E069	-804
chr1	45109585	45109639	E069	-514
chr1	45109726	45109894	E069	-259
chr1	45110625	45110726	E069	472
chr1	45110834	45110899	E069	681
chr1	45111130	45111775	E069	977
chr1	45111850	45111956	E069	1697
chr1	45111998	45112215	E069	1845
chr1	45112221	45112374	E069	2068
chr1	45112468	45112680	E069	2315
chr1	45113488	45113634	E069	3335
chr1	45113717	45113913	E069	3564
chr1	45114246	45114763	E069	4093
chr1	45114853	45114931	E069	4700
chr1	45114993	45115043	E069	4840
chr1	45115847	45116470	E069	5694
chr1	45118174	45118962	E069	8021
chr1	45119024	45119149	E069	8871
chr1	45136231	45136296	E069	26078
chr1	45136838	45136901	E069	26685
chr1	45137778	45138440	E069	27625
chr1	45138478	45138719	E069	28325
chr1	45141223	45141277	E069	31070
chr1	45141951	45142602	E069	31798
chr1	45142679	45142759	E069	32526
chr1	45142769	45143222	E069	32616
chr1	45068548	45068639	E070	-41514
chr1	45068653	45068721	E070	-41432
chr1	45068905	45068976	E070	-41177
chr1	45069057	45069115	E070	-41038
chr1	45069442	45069791	E070	-40362
chr1	45084822	45085543	E070	-24610
chr1	45098812	45098898	E070	-11255
chr1	45099316	45099366	E070	-10787
chr1	45099549	45099653	E070	-10500
chr1	45099684	45099734	E070	-10419
chr1	45125866	45126295	E070	15713
chr1	45060260	45060328	E071	-49825
chr1	45060657	45060723	E071	-49430
chr1	45060747	45061219	E071	-48934
chr1	45062352	45062402	E071	-47751
chr1	45062646	45062787	E071	-47366
chr1	45063208	45063258	E071	-46895
chr1	45063295	45063345	E071	-46808
chr1	45068548	45068639	E071	-41514
chr1	45068653	45068721	E071	-41432
chr1	45068905	45068976	E071	-41177
chr1	45069057	45069115	E071	-41038
chr1	45069442	45069791	E071	-40362
chr1	45069916	45070100	E071	-40053
chr1	45074978	45075111	E071	-35042
chr1	45075189	45075509	E071	-34644
chr1	45075512	45075705	E071	-34448
chr1	45079820	45079904	E071	-30249
chr1	45082275	45082372	E071	-27781
chr1	45083465	45083583	E071	-26570
chr1	45083861	45083927	E071	-26226
chr1	45084250	45084492	E071	-25661
chr1	45084822	45085543	E071	-24610
chr1	45085788	45085868	E071	-24285
chr1	45086083	45086138	E071	-24015
chr1	45086344	45086424	E071	-23729
chr1	45090972	45091356	E071	-18797
chr1	45096309	45096411	E071	-13742
chr1	45096617	45096674	E071	-13479
chr1	45096764	45096916	E071	-13237
chr1	45098812	45098898	E071	-11255
chr1	45099316	45099366	E071	-10787
chr1	45099549	45099653	E071	-10500
chr1	45099684	45099734	E071	-10419
chr1	45099921	45099968	E071	-10185
chr1	45100351	45100577	E071	-9576
chr1	45101657	45101722	E071	-8431
chr1	45105940	45106133	E071	-4020
chr1	45107517	45107568	E071	-2585
chr1	45108071	45108156	E071	-1997
chr1	45108554	45108685	E071	-1468
chr1	45108710	45108847	E071	-1306
chr1	45109296	45109349	E071	-804
chr1	45109585	45109639	E071	-514
chr1	45109726	45109894	E071	-259
chr1	45110625	45110726	E071	472
chr1	45110834	45110899	E071	681
chr1	45111130	45111775	E071	977
chr1	45111850	45111956	E071	1697
chr1	45111998	45112215	E071	1845
chr1	45112221	45112374	E071	2068
chr1	45112468	45112680	E071	2315
chr1	45113488	45113634	E071	3335
chr1	45114246	45114763	E071	4093
chr1	45114853	45114931	E071	4700
chr1	45114993	45115043	E071	4840
chr1	45115847	45116470	E071	5694
chr1	45118174	45118962	E071	8021
chr1	45119024	45119149	E071	8871
chr1	45121328	45121503	E071	11175
chr1	45125866	45126295	E071	15713
chr1	45127443	45128025	E071	17290
chr1	45136838	45136901	E071	26685
chr1	45137778	45138440	E071	27625
chr1	45138478	45138719	E071	28325
chr1	45141223	45141277	E071	31070
chr1	45060260	45060328	E072	-49825
chr1	45060657	45060723	E072	-49430
chr1	45060747	45061219	E072	-48934
chr1	45062352	45062402	E072	-47751
chr1	45062646	45062787	E072	-47366
chr1	45068548	45068639	E072	-41514
chr1	45068653	45068721	E072	-41432
chr1	45068905	45068976	E072	-41177
chr1	45069057	45069115	E072	-41038
chr1	45069442	45069791	E072	-40362
chr1	45069916	45070100	E072	-40053
chr1	45075854	45076044	E072	-34109
chr1	45076076	45076397	E072	-33756
chr1	45081746	45081825	E072	-28328
chr1	45082275	45082372	E072	-27781
chr1	45083465	45083583	E072	-26570
chr1	45083861	45083927	E072	-26226
chr1	45084250	45084492	E072	-25661
chr1	45084822	45085543	E072	-24610
chr1	45085788	45085868	E072	-24285
chr1	45087508	45087942	E072	-22211
chr1	45096764	45096916	E072	-13237
chr1	45098812	45098898	E072	-11255
chr1	45099316	45099366	E072	-10787
chr1	45099549	45099653	E072	-10500
chr1	45099684	45099734	E072	-10419
chr1	45099921	45099968	E072	-10185
chr1	45100351	45100577	E072	-9576
chr1	45101657	45101722	E072	-8431
chr1	45101947	45102008	E072	-8145
chr1	45107517	45107568	E072	-2585
chr1	45108071	45108156	E072	-1997
chr1	45108554	45108685	E072	-1468
chr1	45108710	45108847	E072	-1306
chr1	45109296	45109349	E072	-804
chr1	45109585	45109639	E072	-514
chr1	45109726	45109894	E072	-259
chr1	45110625	45110726	E072	472
chr1	45110834	45110899	E072	681
chr1	45111130	45111775	E072	977
chr1	45111850	45111956	E072	1697
chr1	45111998	45112215	E072	1845
chr1	45112221	45112374	E072	2068
chr1	45112468	45112680	E072	2315
chr1	45113488	45113634	E072	3335
chr1	45113717	45113913	E072	3564
chr1	45114246	45114763	E072	4093
chr1	45114853	45114931	E072	4700
chr1	45114993	45115043	E072	4840
chr1	45115847	45116470	E072	5694
chr1	45118174	45118962	E072	8021
chr1	45121328	45121503	E072	11175
chr1	45127443	45128025	E072	17290
chr1	45128090	45128250	E072	17937
chr1	45128437	45128689	E072	18284
chr1	45137778	45138440	E072	27625
chr1	45138478	45138719	E072	28325
chr1	45142769	45143222	E072	32616
chr1	45060260	45060328	E073	-49825
chr1	45060657	45060723	E073	-49430
chr1	45060747	45061219	E073	-48934
chr1	45062352	45062402	E073	-47751
chr1	45062646	45062787	E073	-47366
chr1	45063208	45063258	E073	-46895
chr1	45063295	45063345	E073	-46808
chr1	45068548	45068639	E073	-41514
chr1	45068653	45068721	E073	-41432
chr1	45068905	45068976	E073	-41177
chr1	45069057	45069115	E073	-41038
chr1	45069442	45069791	E073	-40362
chr1	45069916	45070100	E073	-40053
chr1	45083465	45083583	E073	-26570
chr1	45096617	45096674	E073	-13479
chr1	45096764	45096916	E073	-13237
chr1	45098812	45098898	E073	-11255
chr1	45099316	45099366	E073	-10787
chr1	45099549	45099653	E073	-10500
chr1	45099684	45099734	E073	-10419
chr1	45099921	45099968	E073	-10185
chr1	45100351	45100577	E073	-9576
chr1	45101657	45101722	E073	-8431
chr1	45101947	45102008	E073	-8145
chr1	45102023	45102158	E073	-7995
chr1	45102431	45104057	E073	-6096
chr1	45107517	45107568	E073	-2585
chr1	45108071	45108156	E073	-1997
chr1	45108554	45108685	E073	-1468
chr1	45108710	45108847	E073	-1306
chr1	45109296	45109349	E073	-804
chr1	45109585	45109639	E073	-514
chr1	45109726	45109894	E073	-259
chr1	45110625	45110726	E073	472
chr1	45110834	45110899	E073	681
chr1	45111130	45111775	E073	977
chr1	45111850	45111956	E073	1697
chr1	45114993	45115043	E073	4840
chr1	45115847	45116470	E073	5694
chr1	45118174	45118962	E073	8021
chr1	45125866	45126295	E073	15713
chr1	45127443	45128025	E073	17290
chr1	45128090	45128250	E073	17937
chr1	45128437	45128689	E073	18284
chr1	45136838	45136901	E073	26685
chr1	45137778	45138440	E073	27625
chr1	45138478	45138719	E073	28325
chr1	45060260	45060328	E074	-49825
chr1	45060657	45060723	E074	-49430
chr1	45060747	45061219	E074	-48934
chr1	45062352	45062402	E074	-47751
chr1	45062646	45062787	E074	-47366
chr1	45063208	45063258	E074	-46895
chr1	45063295	45063345	E074	-46808
chr1	45063838	45063913	E074	-46240
chr1	45068548	45068639	E074	-41514
chr1	45068653	45068721	E074	-41432
chr1	45068905	45068976	E074	-41177
chr1	45069057	45069115	E074	-41038
chr1	45069442	45069791	E074	-40362
chr1	45069916	45070100	E074	-40053
chr1	45072090	45072140	E074	-38013
chr1	45074978	45075111	E074	-35042
chr1	45075189	45075509	E074	-34644
chr1	45075512	45075705	E074	-34448
chr1	45075854	45076044	E074	-34109
chr1	45079671	45079803	E074	-30350
chr1	45079820	45079904	E074	-30249
chr1	45080605	45080732	E074	-29421
chr1	45080904	45080962	E074	-29191
chr1	45081508	45081562	E074	-28591
chr1	45081604	45081675	E074	-28478
chr1	45081746	45081825	E074	-28328
chr1	45082275	45082372	E074	-27781
chr1	45083465	45083583	E074	-26570
chr1	45083861	45083927	E074	-26226
chr1	45084250	45084492	E074	-25661
chr1	45084822	45085543	E074	-24610
chr1	45085788	45085868	E074	-24285
chr1	45086083	45086138	E074	-24015
chr1	45086344	45086424	E074	-23729
chr1	45087508	45087942	E074	-22211
chr1	45096309	45096411	E074	-13742
chr1	45096617	45096674	E074	-13479
chr1	45096764	45096916	E074	-13237
chr1	45099316	45099366	E074	-10787
chr1	45099549	45099653	E074	-10500
chr1	45099684	45099734	E074	-10419
chr1	45099921	45099968	E074	-10185
chr1	45100351	45100577	E074	-9576
chr1	45101657	45101722	E074	-8431
chr1	45101947	45102008	E074	-8145
chr1	45105940	45106133	E074	-4020
chr1	45107517	45107568	E074	-2585
chr1	45108071	45108156	E074	-1997
chr1	45108554	45108685	E074	-1468
chr1	45108710	45108847	E074	-1306
chr1	45109296	45109349	E074	-804
chr1	45109585	45109639	E074	-514
chr1	45109726	45109894	E074	-259
chr1	45110625	45110726	E074	472
chr1	45110834	45110899	E074	681
chr1	45111130	45111775	E074	977
chr1	45111850	45111956	E074	1697
chr1	45113488	45113634	E074	3335
chr1	45113717	45113913	E074	3564
chr1	45114246	45114763	E074	4093
chr1	45114853	45114931	E074	4700
chr1	45114993	45115043	E074	4840
chr1	45115847	45116470	E074	5694
chr1	45119024	45119149	E074	8871
chr1	45121328	45121503	E074	11175
chr1	45136838	45136901	E074	26685
chr1	45137778	45138440	E074	27625
chr1	45138478	45138719	E074	28325
chr1	45142769	45143222	E074	32616
chr1	45068548	45068639	E081	-41514
chr1	45068653	45068721	E081	-41432
chr1	45068905	45068976	E081	-41177
chr1	45069057	45069115	E081	-41038
chr1	45090972	45091356	E081	-18797
chr1	45091992	45092058	E081	-18095
chr1	45101657	45101722	E081	-8431
chr1	45101947	45102008	E081	-8145
chr1	45102023	45102158	E081	-7995
chr1	45102431	45104057	E081	-6096
chr1	45141223	45141277	E081	31070
chr1	45099316	45099366	E082	-10787
chr1	45099549	45099653	E082	-10500
chr1	45099684	45099734	E082	-10419
chr1	45099921	45099968	E082	-10185
chr1	45100351	45100577	E082	-9576
chr1	45101657	45101722	E082	-8431
chr1	45101947	45102008	E082	-8145
chr1	45102023	45102158	E082	-7995
chr1	45102431	45104057	E082	-6096
chr1	45137778	45138440	E082	27625
chr1	45138478	45138719	E082	28325

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr1	45082405	45082553	E067	-27600
chr1	45082597	45082665	E067	-27488
chr1	45082726	45083087	E067	-27066
chr1	45096918	45098687	E067	-11466
chr1	45138730	45140922	E067	28577
chr1	45096918	45098687	E068	-11466
chr1	45138730	45140922	E068	28577
chr1	45096918	45098687	E069	-11466
chr1	45138730	45140922	E069	28577
chr1	45096918	45098687	E070	-11466
chr1	45138730	45140922	E070	28577
chr1	45082405	45082553	E071	-27600
chr1	45082597	45082665	E071	-27488
chr1	45082726	45083087	E071	-27066
chr1	45096918	45098687	E071	-11466
chr1	45138730	45140922	E071	28577
chr1	45096918	45098687	E072	-11466
chr1	45138730	45140922	E072	28577
chr1	45096918	45098687	E073	-11466
chr1	45138730	45140922	E073	28577
chr1	45096918	45098687	E074	-11466
chr1	45138730	45140922	E074	28577
chr1	45096918	45098687	E081	-11466
chr1	45138730	45140922	E081	28577
chr1	45096918	45098687	E082	-11466
chr1	45138730	45140922	E082	28577