rs11634945

Homo sapiens
C>T
PRKXP1 : Non Coding Transcript Variant
Check p-value
SNV (Single Nucleotide Variation)
C==0143 (4250/29672,GnomAD)
C==0148 (4314/29118,TOPMED)
C==0251 (1258/5008,1000G)
C==0090 (347/3854,ALSPAC)
C==0092 (340/3708,TWINSUK)
chr15:100553925 (GRCh38.p7) (15q26.3)
AD
GWASdb2
1   publication(s)
See rs on genome
32 Enhancers around
10 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 15NC_000015.10:g.100553925C>T
GRCh37.p13 chr 15NC_000015.9:g.101094130C>T

Gene: PRKXP1, protein kinase, X-linked, pseudogene 1(minus strand)

Molecule type Change Amino acid[Codon] SO Term
PRKXP1 transcriptNR_073405.1:n.535...NR_073405.1:n.5359G>AG>ANon Coding Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.189T=0.811
1000GenomesAmericanSub694C=0.220T=0.780
1000GenomesEast AsianSub1008C=0.602T=0.398
1000GenomesEuropeSub1006C=0.087T=0.913
1000GenomesGlobalStudy-wide5008C=0.251T=0.749
1000GenomesSouth AsianSub978C=0.160T=0.840
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.090T=0.910
The Genome Aggregation DatabaseAfricanSub8626C=0.163T=0.837
The Genome Aggregation DatabaseAmericanSub834C=0.190T=0.810
The Genome Aggregation DatabaseEast AsianSub1592C=0.666T=0.334
The Genome Aggregation DatabaseEuropeSub18320C=0.084T=0.915
The Genome Aggregation DatabaseGlobalStudy-wide29672C=0.143T=0.856
The Genome Aggregation DatabaseOtherSub300C=0.240T=0.760
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.148T=0.851
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.092T=0.908
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs116349450.00065alcohol dependence20201924

eQTL of rs11634945 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr15:101094130CERS3ENSG00000154227.9C>T6.3302e-118930Cerebellum
Chr15:101094130CERS3ENSG00000154227.9C>T1.4305e-98930Cerebellar_Hemisphere

meQTL of rs11634945 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr15101065746101066988E068-27142
chr15101140459101140499E06846329
chr15101140537101140587E06846407
chr15101140873101140917E06846743
chr15101065746101066988E069-27142
chr15101140459101140499E06946329
chr15101140537101140587E06946407
chr15101140873101140917E06946743
chr15101065241101065501E070-28629
chr15101065600101065685E070-28445
chr15101065746101066988E070-27142
chr15101071519101071674E070-22456
chr15101072034101072084E070-22046
chr15101072273101072561E070-21569
chr15101138928101139055E07044798
chr15101139098101139323E07044968
chr15101065746101066988E071-27142
chr15101139098101139323E07144968
chr15101065746101066988E072-27142
chr15101102583101102693E0728453
chr15101140873101140917E07246743
chr15101065746101066988E074-27142
chr15101065241101065501E081-28629
chr15101065600101065685E081-28445
chr15101065746101066988E081-27142
chr15101070215101070505E081-23625
chr15101140873101140917E08146743
chr15101065746101066988E082-27142
chr15101070215101070505E082-23625
chr15101072034101072084E082-22046
chr15101072273101072561E082-21569
chr15101140873101140917E08246743








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr15101141028101143692E06746898
chr15101141028101143692E06846898
chr15101141028101143692E06946898
chr15101141028101143692E07046898
chr15101141028101143692E07146898
chr15101141028101143692E07246898
chr15101141028101143692E07346898
chr15101141028101143692E07446898
chr15101141028101143692E08146898
chr15101141028101143692E08246898