rs11646835

Homo sapiens
G>A
LOC400499 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0295 (8833/29944,GnomAD)
A=0297 (8650/29118,TOPMED)
A=0297 (1486/5008,1000G)
A=0309 (1189/3854,ALSPAC)
A=0288 (1068/3708,TWINSUK)
chr16:11519313 (GRCh38.p7) (16p13.13)
AD
GWASdb2
1   publication(s)
See rs on genome
151 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 16NC_000016.10:g.11519313G>A
GRCh37.p13 chr 16NC_000016.9:g.11613169G>A

Gene: LOC400499, uncharacterized LOC400499(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC400499 transcript variant X1XM_017023929.1:c.N/AIntron Variant
LOC400499 transcript variant X2XM_017023930.1:c.N/AIntron Variant
LOC400499 transcript variant X3XM_017023931.1:c.N/AIntron Variant
LOC400499 transcript variant X4XM_017023932.1:c.N/AIntron Variant
LOC400499 transcript variant X5XM_017023933.1:c.N/AIntron Variant
LOC400499 transcript variant X6XM_017023934.1:c.N/AIntron Variant
LOC400499 transcript variant X7XM_017023935.1:c.N/AIntron Variant
LOC400499 transcript variant X8XM_017023936.1:c.N/AIntron Variant
LOC400499 transcript variant X9XM_017023937.1:c.N/AIntron Variant
LOC400499 transcript variant X10XM_017023938.1:c.N/AIntron Variant
LOC400499 transcript variant X11XM_017023939.1:c.N/AIntron Variant
LOC400499 transcript variant X14XM_017023942.1:c.N/AIntron Variant
LOC400499 transcript variant X16XM_017023944.1:c.N/AIntron Variant
LOC400499 transcript variant X17XM_017023945.1:c.N/AIntron Variant
LOC400499 transcript variant X22XM_017023948.1:c.N/AIntron Variant
LOC400499 transcript variant X23XM_017023949.1:c.N/AIntron Variant
LOC400499 transcript variant X12XM_017023940.1:c.N/AGenic Upstream Transcript Variant
LOC400499 transcript variant X13XM_017023941.1:c.N/AGenic Upstream Transcript Variant
LOC400499 transcript variant X15XM_017023943.1:c.N/AGenic Upstream Transcript Variant
LOC400499 transcript variant X20XM_017023946.1:c.N/AGenic Upstream Transcript Variant
LOC400499 transcript variant X21XM_017023947.1:c.N/AGenic Upstream Transcript Variant
LOC400499 transcript variant X18XR_001752082.1:n.N/AIntron Variant
LOC400499 transcript variant X19XR_001752083.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.651A=0.349
1000GenomesAmericanSub694G=0.780A=0.220
1000GenomesEast AsianSub1008G=0.675A=0.325
1000GenomesEuropeSub1006G=0.703A=0.297
1000GenomesGlobalStudy-wide5008G=0.703A=0.297
1000GenomesSouth AsianSub978G=0.750A=0.250
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.691A=0.309
The Genome Aggregation DatabaseAfricanSub8714G=0.661A=0.339
The Genome Aggregation DatabaseAmericanSub836G=0.810A=0.190
The Genome Aggregation DatabaseEast AsianSub1614G=0.691A=0.309
The Genome Aggregation DatabaseEuropeSub18478G=0.723A=0.276
The Genome Aggregation DatabaseGlobalStudy-wide29944G=0.705A=0.295
The Genome Aggregation DatabaseOtherSub302G=0.630A=0.370
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.702A=0.297
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.712A=0.288
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs116468350.000955alcohol dependence21314694

eQTL of rs11646835 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs11646835 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr161158998511590042E067-23127
chr161159024411590317E067-22852
chr161159038711592192E067-20977
chr161163923611639336E06726067
chr161163939411639564E06726225
chr161165235311652420E06739184
chr161165255811652792E06739389
chr161165729811657765E06744129
chr161158998511590042E068-23127
chr161159024411590317E068-22852
chr161159038711592192E068-20977
chr161159790511598036E068-15133
chr161159806411598210E068-14959
chr161163923611639336E06826067
chr161163939411639564E06826225
chr161164002711640067E06826858
chr161164019711641890E06827028
chr161164193411641986E06828765
chr161164213611642222E06828967
chr161164720811647258E06834039
chr161164737711647445E06834208
chr161164747111647530E06834302
chr161164767211647760E06834503
chr161165151111651629E06838342
chr161165222211652269E06839053
chr161165235311652420E06839184
chr161165255811652792E06839389
chr161158926611589883E069-23286
chr161158998511590042E069-23127
chr161159024411590317E069-22852
chr161159038711592192E069-20977
chr161164019711641890E06927028
chr161164193411641986E06928765
chr161164213611642222E06928967
chr161164632611646628E06933157
chr161164720811647258E06934039
chr161164737711647445E06934208
chr161164747111647530E06934302
chr161164767211647760E06934503
chr161165078611651474E06937617
chr161165151111651629E06938342
chr161165167211652045E06938503
chr161165235311652420E06939184
chr161165255811652792E06939389
chr161165807611658137E06944907
chr161165816211658227E06944993
chr161165829511658414E06945126
chr161165847111658610E06945302
chr161164002711640067E07026858
chr161164019711641890E07027028
chr161164193411641986E07028765
chr161164213611642222E07028967
chr161164282911642879E07029660
chr161164747111647530E07034302
chr161164767211647760E07034503
chr161165210811652169E07038939
chr161165222211652269E07039053
chr161165235311652420E07039184
chr161158912811589227E071-23942
chr161158926611589883E071-23286
chr161158998511590042E071-23127
chr161159024411590317E071-22852
chr161159038711592192E071-20977
chr161159239811592974E071-20195
chr161159790511598036E071-15133
chr161164002711640067E07126858
chr161164019711641890E07127028
chr161164213611642222E07128967
chr161165078611651474E07137617
chr161165255811652792E07139389
chr161165703611657115E07143867
chr161165729811657765E07144129
chr161165785311657893E07144684
chr161165791311657953E07144744
chr161165807611658137E07144907
chr161165816211658227E07144993
chr161165829511658414E07145126
chr161165847111658610E07145302
chr161165872011658845E07145551
chr161159038711592192E072-20977
chr161164019711641890E07227028
chr161164193411641986E07228765
chr161164213611642222E07228967
chr161164307011643130E07229901
chr161164720811647258E07234039
chr161164737711647445E07234208
chr161164747111647530E07234302
chr161164767211647760E07234503
chr161165151111651629E07238342
chr161165167211652045E07238503
chr161165785311657893E07244684
chr161165791311657953E07244744
chr161165807611658137E07244907
chr161165816211658227E07244993
chr161165829511658414E07245126
chr161165847111658610E07245302
chr161165872011658845E07245551
chr161158912811589227E073-23942
chr161159024411590317E073-22852
chr161159038711592192E073-20977
chr161165807611658137E07344907
chr161165816211658227E07344993
chr161165829511658414E07345126
chr161165847111658610E07345302
chr161165872011658845E07345551
chr161158912811589227E074-23942
chr161158926611589883E074-23286
chr161158998511590042E074-23127
chr161159024411590317E074-22852
chr161159038711592192E074-20977
chr161159239811592974E074-20195
chr161159314411593796E074-19373
chr161163884811639134E07425679
chr161163923611639336E07426067
chr161163939411639564E07426225
chr161163956511639631E07426396
chr161164002711640067E07426858
chr161164019711641890E07427028
chr161164193411641986E07428765
chr161164213611642222E07428967
chr161164307011643130E07429901
chr161164720811647258E07434039
chr161164737711647445E07434208
chr161164747111647530E07434302
chr161164767211647760E07434503
chr161164977311650242E07436604
chr161165025811650310E07437089
chr161165045111650701E07437282
chr161165078611651474E07437617
chr161165151111651629E07438342
chr161165167211652045E07438503
chr161165210811652169E07438939
chr161165222211652269E07439053
chr161165235311652420E07439184
chr161165255811652792E07439389
chr161165729811657765E07444129
chr161165785311657893E07444684
chr161165791311657953E07444744
chr161165807611658137E07444907
chr161165816211658227E07444993
chr161165829511658414E07445126
chr161165847111658610E07445302
chr161165872011658845E07445551
chr161159038711592192E081-20977
chr161163613011636241E08122961
chr161163625911636562E08123090
chr161164019711641890E08127028
chr161163625911636562E08223090
chr161164019711641890E08227028
chr161164193411641986E08228765
chr161165151111651629E08238342