rs11654695

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
C==0166 (4997/29964,GnomAD)
C==0167 (4873/29118,TOPMED)
C==0172 (862/5008,1000G)
C==0199 (766/3854,ALSPAC)
C==0195 (724/3708,TWINSUK)
chr17:209189 (GRCh38.p7) (17p13.3)
ND
GWASdb2
1   publication(s)
See rs on genome
163 Enhancers around
37 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 17NC_000017.11:g.209189C>T
GRCh37.p13 chr 17 fix patch HG417_PATCHNW_004070872.2:g.149187C>T
GRCh38.p7 chr 17 alt locus HSCHR17_1_CTG1NW_003315952.3:g.154231T>C
GRCh37.p13 chr 17NC_000017.10:g.58980C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.096T=0.904
1000GenomesAmericanSub694C=0.180T=0.820
1000GenomesEast AsianSub1008C=0.230T=0.770
1000GenomesEuropeSub1006C=0.199T=0.801
1000GenomesGlobalStudy-wide5008C=0.172T=0.828
1000GenomesSouth AsianSub978C=0.180T=0.820
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.199T=0.801
The Genome Aggregation DatabaseAfricanSub8724C=0.110T=0.890
The Genome Aggregation DatabaseAmericanSub838C=0.190T=0.810
The Genome Aggregation DatabaseEast AsianSub1616C=0.230T=0.770
The Genome Aggregation DatabaseEuropeSub18484C=0.185T=0.814
The Genome Aggregation DatabaseGlobalStudy-wide29964C=0.166T=0.833
The Genome Aggregation DatabaseOtherSub302C=0.240T=0.760
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.167T=0.832
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.195T=0.805
PMID Title Author Journal
19268276Genome-wide association study of smoking initiation and current smoking.Vink JMAm J Hum Genet

P-Value

SNP ID p-value Traits Study
rs116546956.78E-05nicotine smoking19268276

eQTL of rs11654695 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs11654695 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr17159698160308E06710511
chr17183384183538E06734197
chr17183551183753E06734364
chr17115542116033E068-33154
chr17157463158121E0688276
chr17158129158233E0688942
chr17183029183198E06833842
chr17115542116033E069-33154
chr17116041116095E069-33092
chr17116375116457E069-32730
chr17154074154717E0694887
chr17159037159645E0699850
chr17159698160308E06910511
chr17160355160628E06911168
chr17180231180428E06931044
chr17180504180558E06931317
chr17183029183198E06933842
chr17183384183538E06934197
chr17183551183753E06934364
chr17184432184489E06935245
chr17188389188627E06939202
chr17109180109478E070-39709
chr17109497110447E070-38740
chr17110526110586E070-38601
chr17110611110661E070-38526
chr17110690110745E070-38442
chr17115542116033E070-33154
chr17116041116095E070-33092
chr17116375116457E070-32730
chr17116483116740E070-32447
chr17116772116886E070-32301
chr17116921117586E070-31601
chr17117588117722E070-31465
chr17154814155468E0705627
chr17155846155935E0706659
chr17156007156062E0706820
chr17156114156164E0706927
chr17156224156358E0707037
chr17156366156602E0707179
chr17159037159645E0709850
chr17159698160308E07010511
chr17160355160628E07011168
chr17160770161331E07011583
chr17161375161913E07012188
chr17183551183753E07034364
chr17185438185825E07036251
chr17185871186548E07036684
chr17186583186743E07037396
chr17109180109478E071-39709
chr17109497110447E071-38740
chr17116483116740E071-32447
chr17116772116886E071-32301
chr17116921117586E071-31601
chr17117588117722E071-31465
chr17157463158121E0718276
chr17158129158233E0718942
chr17158357158413E0719170
chr17158525158575E0719338
chr17159037159645E0719850
chr17159698160308E07110511
chr17180231180428E07131044
chr17180504180558E07131317
chr17183029183198E07133842
chr17183384183538E07134197
chr17183551183753E07134364
chr17115542116033E072-33154
chr17116041116095E072-33092
chr17116375116457E072-32730
chr17116483116740E072-32447
chr17116772116886E072-32301
chr17116921117586E072-31601
chr17117588117722E072-31465
chr17154074154717E0724887
chr17159037159645E0729850
chr17159698160308E07210511
chr17160355160628E07211168
chr17160770161331E07211583
chr17184432184489E07235245
chr17184770185216E07235583
chr17185438185825E07236251
chr17116041116095E073-33092
chr17116375116457E073-32730
chr17116483116740E073-32447
chr17116772116886E073-32301
chr17116921117586E073-31601
chr17119442119492E073-29695
chr17119546119596E073-29591
chr17146258146379E073-2808
chr17146566146616E073-2571
chr17158989159033E0739802
chr17159037159645E0739850
chr17159698160308E07310511
chr17184432184489E07335245
chr17184770185216E07335583
chr17116921117586E074-31601
chr17117588117722E074-31465
chr17180231180428E07431044
chr17180504180558E07431317
chr17183029183198E07433842
chr17183384183538E07434197
chr17184432184489E07435245
chr17108399108489E081-40698
chr17109180109478E081-39709
chr17109497110447E081-38740
chr17110526110586E081-38601
chr17110611110661E081-38526
chr17110690110745E081-38442
chr17115542116033E081-33154
chr17116041116095E081-33092
chr17116375116457E081-32730
chr17116483116740E081-32447
chr17116772116886E081-32301
chr17116921117586E081-31601
chr17117588117722E081-31465
chr17119442119492E081-29695
chr17119546119596E081-29591
chr17119787120156E081-29031
chr17130836130923E081-18264
chr17131010131050E081-18137
chr17131253131303E081-17884
chr17140172140247E081-8940
chr17140266140353E081-8834
chr17140504140619E081-8568
chr17140646140697E081-8490
chr17142007142057E081-7130
chr17142462143207E081-5980
chr17157341157434E0818154
chr17157463158121E0818276
chr17159037159645E0819850
chr17159698160308E08110511
chr17160355160628E08111168
chr17160770161331E08111583
chr17171258172015E08122071
chr17172107172290E08122920
chr17172761172801E08123574
chr17180231180428E08131044
chr17180504180558E08131317
chr17184770185216E08135583
chr17185240185316E08136053
chr17185340185390E08136153
chr17185438185825E08136251
chr17187268187643E08138081
chr17109180109478E082-39709
chr17109497110447E082-38740
chr17110526110586E082-38601
chr17115319115369E082-33818
chr17115542116033E082-33154
chr17116041116095E082-33092
chr17116375116457E082-32730
chr17116483116740E082-32447
chr17116772116886E082-32301
chr17116921117586E082-31601
chr17117588117722E082-31465
chr17119442119492E082-29695
chr17119546119596E082-29591
chr17119787120156E082-29031
chr17120357120437E082-28750
chr17142007142057E082-7130
chr17159698160308E08210511
chr17160355160628E08211168
chr17172107172290E08222920
chr17185438185825E08236251
chr17185871186548E08236684










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr17181153181448E06731966
chr17181626181692E06732439
chr17181757181878E06732570
chr17181923182203E06732736
chr17183766184305E06734579
chr17181153181448E06831966
chr17181626181692E06832439
chr17181757181878E06832570
chr17181923182203E06832736
chr17182231182953E06833044
chr17183766184305E06834579
chr17181153181448E06931966
chr17181626181692E06932439
chr17181757181878E06932570
chr17181923182203E06932736
chr17183766184305E06934579
chr17181153181448E07131966
chr17181626181692E07132439
chr17181757181878E07132570
chr17183766184305E07134579
chr17181153181448E07231966
chr17181626181692E07232439
chr17181757181878E07232570
chr17181923182203E07232736
chr17182231182953E07233044
chr17183766184305E07234579
chr17181153181448E07331966
chr17181626181692E07332439
chr17181757181878E07332570
chr17181923182203E07332736
chr17182231182953E07333044
chr17183766184305E07334579
chr17181153181448E07431966
chr17181626181692E07432439
chr17181757181878E07432570
chr17181923182203E07432736
chr17183766184305E07434579