rs11666282

Organism: Homo sapiens

Alleles: C>T

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

T=0284 (8511/29922,GnomAD)
T=0339 (9886/29118,TOPMED)
T=0377 (1890/5008,1000G)
T=0215 (830/3854,ALSPAC)
T=0204 (756/3708,TWINSUK)

Position: chr19:35316942 (GRCh38.p7) (19q13.12)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 259 Enhancers around

Promoter: 95 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 19	NC_000019.10:g.35316942C>T
GRCh37.p13 chr 19	NC_000019.9:g.35807845C>T

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	C=0.543	T=0.457
1000Genomes	American	Sub	694	C=0.670	T=0.330
1000Genomes	East Asian	Sub	1008	C=0.632	T=0.368
1000Genomes	Europe	Sub	1006	C=0.769	T=0.231
1000Genomes	Global	Study-wide	5008	C=0.623	T=0.377
1000Genomes	South Asian	Sub	978	C=0.540	T=0.460
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	C=0.785	T=0.215
The Genome Aggregation Database	African	Sub	8700	C=0.576	T=0.424
The Genome Aggregation Database	American	Sub	836	C=0.680	T=0.320
The Genome Aggregation Database	East Asian	Sub	1616	C=0.645	T=0.355
The Genome Aggregation Database	Europe	Sub	18470	C=0.789	T=0.210
The Genome Aggregation Database	Global	Study-wide	29922	C=0.715	T=0.284
The Genome Aggregation Database	Other	Sub	300	C=0.680	T=0.320
Trans-Omics for Precision Medicine	Global	Study-wide	29118	C=0.660	T=0.339
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	C=0.796	T=0.204

PMID	Title	Author	Journal
20201924	Genome-wide association study of alcohol dependence implicates a region on chromosome 11.	Edenberg HJ	Alcohol Clin Exp Res

P-Value

SNP ID	p-value	Traits	Study
rs11666282	0.00077	alcohol dependence	20201924

eQTL of rs11666282 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs11666282 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr19	35761895	35761961	E067	-45884
chr19	35762137	35762325	E067	-45520
chr19	35762331	35762381	E067	-45464
chr19	35762429	35762637	E067	-45208
chr19	35762685	35762828	E067	-45017
chr19	35762876	35762960	E067	-44885
chr19	35762998	35763641	E067	-44204
chr19	35775583	35775698	E067	-32147
chr19	35775699	35775984	E067	-31861
chr19	35776044	35776240	E067	-31605
chr19	35776272	35776373	E067	-31472
chr19	35779897	35780073	E067	-27772
chr19	35780099	35780149	E067	-27696
chr19	35780215	35780306	E067	-27539
chr19	35780343	35780407	E067	-27438
chr19	35781276	35781352	E067	-26493
chr19	35781423	35781574	E067	-26271
chr19	35781676	35781770	E067	-26075
chr19	35786200	35786284	E067	-21561
chr19	35786288	35786384	E067	-21461
chr19	35789290	35789483	E067	-18362
chr19	35789514	35789840	E067	-18005
chr19	35789954	35790014	E067	-17831
chr19	35794365	35794409	E067	-13436
chr19	35794476	35794526	E067	-13319
chr19	35794846	35794998	E067	-12847
chr19	35795043	35795099	E067	-12746
chr19	35796183	35796256	E067	-11589
chr19	35796267	35796376	E067	-11469
chr19	35796388	35796511	E067	-11334
chr19	35796545	35796589	E067	-11256
chr19	35809520	35810610	E067	1675
chr19	35810961	35811880	E067	3116
chr19	35811886	35811968	E067	4041
chr19	35817507	35817561	E067	9662
chr19	35764555	35764840	E068	-43005
chr19	35770720	35772093	E068	-35752
chr19	35772199	35772522	E068	-35323
chr19	35776272	35776373	E068	-31472
chr19	35781276	35781352	E068	-26493
chr19	35781676	35781770	E068	-26075
chr19	35789514	35789840	E068	-18005
chr19	35789954	35790014	E068	-17831
chr19	35790188	35790238	E068	-17607
chr19	35794005	35794055	E068	-13790
chr19	35794057	35794105	E068	-13740
chr19	35794365	35794409	E068	-13436
chr19	35794476	35794526	E068	-13319
chr19	35796388	35796511	E068	-11334
chr19	35796545	35796589	E068	-11256
chr19	35808033	35808799	E068	188
chr19	35809520	35810610	E068	1675
chr19	35810961	35811880	E068	3116
chr19	35811886	35811968	E068	4041
chr19	35761895	35761961	E069	-45884
chr19	35762137	35762325	E069	-45520
chr19	35762331	35762381	E069	-45464
chr19	35762429	35762637	E069	-45208
chr19	35770720	35772093	E069	-35752
chr19	35775583	35775698	E069	-32147
chr19	35775699	35775984	E069	-31861
chr19	35781276	35781352	E069	-26493
chr19	35781676	35781770	E069	-26075
chr19	35786430	35787385	E069	-20460
chr19	35789160	35789247	E069	-18598
chr19	35789290	35789483	E069	-18362
chr19	35789514	35789840	E069	-18005
chr19	35789954	35790014	E069	-17831
chr19	35790188	35790238	E069	-17607
chr19	35791536	35791590	E069	-16255
chr19	35792101	35792188	E069	-15657
chr19	35792353	35792437	E069	-15408
chr19	35793181	35793259	E069	-14586
chr19	35793375	35793419	E069	-14426
chr19	35793525	35793631	E069	-14214
chr19	35794005	35794055	E069	-13790
chr19	35794057	35794105	E069	-13740
chr19	35794365	35794409	E069	-13436
chr19	35794476	35794526	E069	-13319
chr19	35794846	35794998	E069	-12847
chr19	35795043	35795099	E069	-12746
chr19	35796183	35796256	E069	-11589
chr19	35796267	35796376	E069	-11469
chr19	35796388	35796511	E069	-11334
chr19	35796545	35796589	E069	-11256
chr19	35799823	35799900	E069	-7945
chr19	35799955	35800050	E069	-7795
chr19	35800115	35801282	E069	-6563
chr19	35809520	35810610	E069	1675
chr19	35810961	35811880	E069	3116
chr19	35811886	35811968	E069	4041
chr19	35843419	35844174	E069	35574
chr19	35848696	35849479	E070	40851
chr19	35761895	35761961	E071	-45884
chr19	35762137	35762325	E071	-45520
chr19	35762331	35762381	E071	-45464
chr19	35762429	35762637	E071	-45208
chr19	35762685	35762828	E071	-45017
chr19	35762876	35762960	E071	-44885
chr19	35762998	35763641	E071	-44204
chr19	35763817	35763886	E071	-43959
chr19	35763994	35764069	E071	-43776
chr19	35764128	35764225	E071	-43620
chr19	35764330	35764388	E071	-43457
chr19	35764555	35764840	E071	-43005
chr19	35770720	35772093	E071	-35752
chr19	35772199	35772522	E071	-35323
chr19	35772574	35772643	E071	-35202
chr19	35776272	35776373	E071	-31472
chr19	35779897	35780073	E071	-27772
chr19	35780099	35780149	E071	-27696
chr19	35780215	35780306	E071	-27539
chr19	35780343	35780407	E071	-27438
chr19	35781276	35781352	E071	-26493
chr19	35788805	35789090	E071	-18755
chr19	35789160	35789247	E071	-18598
chr19	35789290	35789483	E071	-18362
chr19	35789514	35789840	E071	-18005
chr19	35789954	35790014	E071	-17831
chr19	35790188	35790238	E071	-17607
chr19	35793181	35793259	E071	-14586
chr19	35793375	35793419	E071	-14426
chr19	35793525	35793631	E071	-14214
chr19	35794005	35794055	E071	-13790
chr19	35794057	35794105	E071	-13740
chr19	35794365	35794409	E071	-13436
chr19	35794476	35794526	E071	-13319
chr19	35794846	35794998	E071	-12847
chr19	35795043	35795099	E071	-12746
chr19	35796183	35796256	E071	-11589
chr19	35796267	35796376	E071	-11469
chr19	35796388	35796511	E071	-11334
chr19	35796545	35796589	E071	-11256
chr19	35796799	35797300	E071	-10545
chr19	35797657	35798054	E071	-9791
chr19	35798139	35798189	E071	-9656
chr19	35798216	35798454	E071	-9391
chr19	35798632	35798805	E071	-9040
chr19	35798850	35799384	E071	-8461
chr19	35799823	35799900	E071	-7945
chr19	35799955	35800050	E071	-7795
chr19	35800115	35801282	E071	-6563
chr19	35808033	35808799	E071	188
chr19	35809520	35810610	E071	1675
chr19	35810961	35811880	E071	3116
chr19	35811886	35811968	E071	4041
chr19	35812070	35812182	E071	4225
chr19	35817507	35817561	E071	9662
chr19	35762429	35762637	E072	-45208
chr19	35762685	35762828	E072	-45017
chr19	35762876	35762960	E072	-44885
chr19	35770720	35772093	E072	-35752
chr19	35772199	35772522	E072	-35323
chr19	35776044	35776240	E072	-31605
chr19	35779897	35780073	E072	-27772
chr19	35780099	35780149	E072	-27696
chr19	35780215	35780306	E072	-27539
chr19	35780343	35780407	E072	-27438
chr19	35781276	35781352	E072	-26493
chr19	35781423	35781574	E072	-26271
chr19	35781676	35781770	E072	-26075
chr19	35785362	35785439	E072	-22406
chr19	35785450	35785526	E072	-22319
chr19	35785702	35785828	E072	-22017
chr19	35785878	35785918	E072	-21927
chr19	35786000	35786161	E072	-21684
chr19	35786200	35786284	E072	-21561
chr19	35786288	35786384	E072	-21461
chr19	35786430	35787385	E072	-20460
chr19	35788805	35789090	E072	-18755
chr19	35789160	35789247	E072	-18598
chr19	35789290	35789483	E072	-18362
chr19	35789514	35789840	E072	-18005
chr19	35789954	35790014	E072	-17831
chr19	35790188	35790238	E072	-17607
chr19	35793181	35793259	E072	-14586
chr19	35793375	35793419	E072	-14426
chr19	35793525	35793631	E072	-14214
chr19	35794005	35794055	E072	-13790
chr19	35794057	35794105	E072	-13740
chr19	35794365	35794409	E072	-13436
chr19	35794476	35794526	E072	-13319
chr19	35794846	35794998	E072	-12847
chr19	35795043	35795099	E072	-12746
chr19	35796183	35796256	E072	-11589
chr19	35796267	35796376	E072	-11469
chr19	35796388	35796511	E072	-11334
chr19	35796545	35796589	E072	-11256
chr19	35797657	35798054	E072	-9791
chr19	35798139	35798189	E072	-9656
chr19	35798216	35798454	E072	-9391
chr19	35798632	35798805	E072	-9040
chr19	35799823	35799900	E072	-7945
chr19	35808033	35808799	E072	188
chr19	35809520	35810610	E072	1675
chr19	35810961	35811880	E072	3116
chr19	35811886	35811968	E072	4041
chr19	35761895	35761961	E073	-45884
chr19	35762137	35762325	E073	-45520
chr19	35762331	35762381	E073	-45464
chr19	35762429	35762637	E073	-45208
chr19	35762685	35762828	E073	-45017
chr19	35762876	35762960	E073	-44885
chr19	35762998	35763641	E073	-44204
chr19	35768404	35768448	E073	-39397
chr19	35768610	35768673	E073	-39172
chr19	35768739	35768896	E073	-38949
chr19	35768938	35769122	E073	-38723
chr19	35770720	35772093	E073	-35752
chr19	35772199	35772522	E073	-35323
chr19	35775583	35775698	E073	-32147
chr19	35775699	35775984	E073	-31861
chr19	35776044	35776240	E073	-31605
chr19	35794365	35794409	E073	-13436
chr19	35809520	35810610	E073	1675
chr19	35762137	35762325	E074	-45520
chr19	35762331	35762381	E074	-45464
chr19	35762429	35762637	E074	-45208
chr19	35762685	35762828	E074	-45017
chr19	35762876	35762960	E074	-44885
chr19	35762998	35763641	E074	-44204
chr19	35770720	35772093	E074	-35752
chr19	35781276	35781352	E074	-26493
chr19	35781423	35781574	E074	-26271
chr19	35781676	35781770	E074	-26075
chr19	35785450	35785526	E074	-22319
chr19	35785702	35785828	E074	-22017
chr19	35786430	35787385	E074	-20460
chr19	35788036	35788449	E074	-19396
chr19	35788553	35788687	E074	-19158
chr19	35788805	35789090	E074	-18755
chr19	35789160	35789247	E074	-18598
chr19	35789290	35789483	E074	-18362
chr19	35789514	35789840	E074	-18005
chr19	35789954	35790014	E074	-17831
chr19	35790188	35790238	E074	-17607
chr19	35791536	35791590	E074	-16255
chr19	35794005	35794055	E074	-13790
chr19	35794057	35794105	E074	-13740
chr19	35794846	35794998	E074	-12847
chr19	35795043	35795099	E074	-12746
chr19	35796183	35796256	E074	-11589
chr19	35796267	35796376	E074	-11469
chr19	35796388	35796511	E074	-11334
chr19	35796545	35796589	E074	-11256
chr19	35797657	35798054	E074	-9791
chr19	35798139	35798189	E074	-9656
chr19	35798216	35798454	E074	-9391
chr19	35798632	35798805	E074	-9040
chr19	35798850	35799384	E074	-8461
chr19	35799823	35799900	E074	-7945
chr19	35799955	35800050	E074	-7795
chr19	35800115	35801282	E074	-6563
chr19	35807499	35807994	E074	0
chr19	35808033	35808799	E074	188
chr19	35809520	35810610	E074	1675
chr19	35810961	35811880	E074	3116
chr19	35811886	35811968	E074	4041
chr19	35848696	35849479	E082	40851

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr19	35782348	35782511	E067	-25334
chr19	35782637	35782687	E067	-25158
chr19	35782743	35782783	E067	-25062
chr19	35783022	35783072	E067	-24773
chr19	35783175	35783282	E067	-24563
chr19	35783432	35783592	E067	-24253
chr19	35783683	35783743	E067	-24102
chr19	35783816	35783961	E067	-23884
chr19	35783973	35784075	E067	-23770
chr19	35784076	35784261	E067	-23584
chr19	35784356	35784530	E067	-23315
chr19	35784693	35784833	E067	-23012
chr19	35784872	35784922	E067	-22923
chr19	35774195	35774402	E068	-33443
chr19	35774555	35774611	E068	-33234
chr19	35782348	35782511	E068	-25334
chr19	35782637	35782687	E068	-25158
chr19	35782743	35782783	E068	-25062
chr19	35783022	35783072	E068	-24773
chr19	35783175	35783282	E068	-24563
chr19	35783432	35783592	E068	-24253
chr19	35783683	35783743	E068	-24102
chr19	35783816	35783961	E068	-23884
chr19	35783973	35784075	E068	-23770
chr19	35784076	35784261	E068	-23584
chr19	35784356	35784530	E068	-23315
chr19	35784693	35784833	E068	-23012
chr19	35784872	35784922	E068	-22923
chr19	35782348	35782511	E069	-25334
chr19	35782637	35782687	E069	-25158
chr19	35782743	35782783	E069	-25062
chr19	35783022	35783072	E069	-24773
chr19	35783175	35783282	E069	-24563
chr19	35783432	35783592	E069	-24253
chr19	35783683	35783743	E069	-24102
chr19	35783816	35783961	E069	-23884
chr19	35783973	35784075	E069	-23770
chr19	35784076	35784261	E069	-23584
chr19	35784356	35784530	E069	-23315
chr19	35784693	35784833	E069	-23012
chr19	35784872	35784922	E069	-22923
chr19	35774195	35774402	E071	-33443
chr19	35774555	35774611	E071	-33234
chr19	35782348	35782511	E071	-25334
chr19	35782637	35782687	E071	-25158
chr19	35782743	35782783	E071	-25062
chr19	35783022	35783072	E071	-24773
chr19	35783175	35783282	E071	-24563
chr19	35783432	35783592	E071	-24253
chr19	35783683	35783743	E071	-24102
chr19	35783816	35783961	E071	-23884
chr19	35783973	35784075	E071	-23770
chr19	35784076	35784261	E071	-23584
chr19	35784356	35784530	E071	-23315
chr19	35784693	35784833	E071	-23012
chr19	35784872	35784922	E071	-22923
chr19	35782348	35782511	E072	-25334
chr19	35782637	35782687	E072	-25158
chr19	35782743	35782783	E072	-25062
chr19	35783022	35783072	E072	-24773
chr19	35783175	35783282	E072	-24563
chr19	35783432	35783592	E072	-24253
chr19	35783683	35783743	E072	-24102
chr19	35783816	35783961	E072	-23884
chr19	35783973	35784075	E072	-23770
chr19	35784076	35784261	E072	-23584
chr19	35784356	35784530	E072	-23315
chr19	35784693	35784833	E072	-23012
chr19	35784872	35784922	E072	-22923
chr19	35782348	35782511	E073	-25334
chr19	35782637	35782687	E073	-25158
chr19	35782743	35782783	E073	-25062
chr19	35783022	35783072	E073	-24773
chr19	35783175	35783282	E073	-24563
chr19	35783432	35783592	E073	-24253
chr19	35783683	35783743	E073	-24102
chr19	35783816	35783961	E073	-23884
chr19	35783973	35784075	E073	-23770
chr19	35784076	35784261	E073	-23584
chr19	35784356	35784530	E073	-23315
chr19	35784693	35784833	E073	-23012
chr19	35784872	35784922	E073	-22923
chr19	35782348	35782511	E074	-25334
chr19	35782637	35782687	E074	-25158
chr19	35782743	35782783	E074	-25062
chr19	35783022	35783072	E074	-24773
chr19	35783175	35783282	E074	-24563
chr19	35783432	35783592	E074	-24253
chr19	35783683	35783743	E074	-24102
chr19	35783816	35783961	E074	-23884
chr19	35783973	35784075	E074	-23770
chr19	35784076	35784261	E074	-23584
chr19	35784356	35784530	E074	-23315
chr19	35784693	35784833	E074	-23012
chr19	35784872	35784922	E074	-22923