rs11667918

Organism: Homo sapiens

Alleles: C>T

Gene : Feature

MYO9B : Intron Variant

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

T=0256 (7679/29914,GnomAD)
T=0239 (6970/29118,TOPMED)
T=0261 (1306/5008,1000G)
T=0268 (1031/3854,ALSPAC)
T=0256 (949/3708,TWINSUK)

Position: chr19:17121689 (GRCh38.p7) (19p13.11)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 345 Enhancers around

Promoter: 9 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 19	NC_000019.10:g.17121689C>T
GRCh37.p13 chr 19	NC_000019.9:g.17232499C>T
MYO9B RefSeqGene	NG_013068.1:g.50909C>T

Gene: MYO9B, myosin IXB(plus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
MYO9B transcript variant 2	NM_001130065.1:c.	N/A	Intron Variant
MYO9B transcript variant 1	NM_004145.3:c.	N/A	Intron Variant

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	C=0.790	T=0.210
1000Genomes	American	Sub	694	C=0.760	T=0.240
1000Genomes	East Asian	Sub	1008	C=0.595	T=0.405
1000Genomes	Europe	Sub	1006	C=0.735	T=0.265
1000Genomes	Global	Study-wide	5008	C=0.739	T=0.261
1000Genomes	South Asian	Sub	978	C=0.810	T=0.190
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	C=0.732	T=0.268
The Genome Aggregation Database	African	Sub	8716	C=0.781	T=0.219
The Genome Aggregation Database	American	Sub	836	C=0.770	T=0.230
The Genome Aggregation Database	East Asian	Sub	1618	C=0.560	T=0.440
The Genome Aggregation Database	Europe	Sub	18442	C=0.740	T=0.259
The Genome Aggregation Database	Global	Study-wide	29914	C=0.743	T=0.256
The Genome Aggregation Database	Other	Sub	302	C=0.750	T=0.250
Trans-Omics for Precision Medicine	Global	Study-wide	29118	C=0.760	T=0.239
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	C=0.744	T=0.256

PMID	Title	Author	Journal
21314694	Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.	Kendler KS	Alcohol Clin Exp Res

P-Value

SNP ID	p-value	Traits	Study
rs11667918	0.000877	alcohol dependence	21314694

eQTL of rs11667918 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs11667918 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr19	17188658	17189123	E067	-43376
chr19	17189452	17189709	E067	-42790
chr19	17189741	17189854	E067	-42645
chr19	17192642	17193371	E067	-39128
chr19	17193687	17193799	E067	-38700
chr19	17193919	17193998	E067	-38501
chr19	17194016	17194091	E067	-38408
chr19	17194101	17194207	E067	-38292
chr19	17194217	17194304	E067	-38195
chr19	17194341	17194413	E067	-38086
chr19	17195796	17195931	E067	-36568
chr19	17195974	17196061	E067	-36438
chr19	17196074	17196195	E067	-36304
chr19	17196706	17197216	E067	-35283
chr19	17197682	17197981	E067	-34518
chr19	17199372	17199546	E067	-32953
chr19	17199629	17199802	E067	-32697
chr19	17199832	17201080	E067	-31419
chr19	17215858	17215908	E067	-16591
chr19	17217901	17218027	E067	-14472
chr19	17218108	17218196	E067	-14303
chr19	17218276	17219491	E067	-13008
chr19	17226685	17226857	E067	-5642
chr19	17226977	17227027	E067	-5472
chr19	17227078	17227176	E067	-5323
chr19	17227216	17227266	E067	-5233
chr19	17227681	17227747	E067	-4752
chr19	17227903	17227959	E067	-4540
chr19	17228082	17228172	E067	-4327
chr19	17228206	17228382	E067	-4117
chr19	17228400	17228486	E067	-4013
chr19	17228788	17229024	E067	-3475
chr19	17235626	17235975	E067	3127
chr19	17235980	17237467	E067	3481
chr19	17245241	17245404	E067	12742
chr19	17245577	17245635	E067	13078
chr19	17245823	17247458	E067	13324
chr19	17247468	17247730	E067	14969
chr19	17189452	17189709	E068	-42790
chr19	17191554	17191614	E068	-40885
chr19	17191768	17191818	E068	-40681
chr19	17192642	17193371	E068	-39128
chr19	17193460	17193500	E068	-38999
chr19	17193578	17193636	E068	-38863
chr19	17193687	17193799	E068	-38700
chr19	17193919	17193998	E068	-38501
chr19	17194016	17194091	E068	-38408
chr19	17194101	17194207	E068	-38292
chr19	17194217	17194304	E068	-38195
chr19	17194341	17194413	E068	-38086
chr19	17195796	17195931	E068	-36568
chr19	17195974	17196061	E068	-36438
chr19	17196074	17196195	E068	-36304
chr19	17196590	17196656	E068	-35843
chr19	17196706	17197216	E068	-35283
chr19	17197682	17197981	E068	-34518
chr19	17199629	17199802	E068	-32697
chr19	17199832	17201080	E068	-31419
chr19	17218276	17219491	E068	-13008
chr19	17220489	17221449	E068	-11050
chr19	17221451	17221516	E068	-10983
chr19	17226685	17226857	E068	-5642
chr19	17226977	17227027	E068	-5472
chr19	17227078	17227176	E068	-5323
chr19	17227216	17227266	E068	-5233
chr19	17227681	17227747	E068	-4752
chr19	17227903	17227959	E068	-4540
chr19	17228082	17228172	E068	-4327
chr19	17228206	17228382	E068	-4117
chr19	17228400	17228486	E068	-4013
chr19	17235980	17237467	E068	3481
chr19	17188658	17189123	E069	-43376
chr19	17191768	17191818	E069	-40681
chr19	17191979	17192053	E069	-40446
chr19	17192214	17192268	E069	-40231
chr19	17193460	17193500	E069	-38999
chr19	17193578	17193636	E069	-38863
chr19	17193687	17193799	E069	-38700
chr19	17193919	17193998	E069	-38501
chr19	17194016	17194091	E069	-38408
chr19	17194101	17194207	E069	-38292
chr19	17194217	17194304	E069	-38195
chr19	17194341	17194413	E069	-38086
chr19	17195796	17195931	E069	-36568
chr19	17195974	17196061	E069	-36438
chr19	17196074	17196195	E069	-36304
chr19	17197682	17197981	E069	-34518
chr19	17198025	17198226	E069	-34273
chr19	17198236	17198340	E069	-34159
chr19	17199114	17199178	E069	-33321
chr19	17199372	17199546	E069	-32953
chr19	17199629	17199802	E069	-32697
chr19	17199832	17201080	E069	-31419
chr19	17202411	17203206	E069	-29293
chr19	17215858	17215908	E069	-16591
chr19	17217901	17218027	E069	-14472
chr19	17218108	17218196	E069	-14303
chr19	17218276	17219491	E069	-13008
chr19	17221451	17221516	E069	-10983
chr19	17223042	17223096	E069	-9403
chr19	17223120	17223160	E069	-9339
chr19	17223190	17223259	E069	-9240
chr19	17226977	17227027	E069	-5472
chr19	17227078	17227176	E069	-5323
chr19	17227216	17227266	E069	-5233
chr19	17227681	17227747	E069	-4752
chr19	17227903	17227959	E069	-4540
chr19	17228082	17228172	E069	-4327
chr19	17228206	17228382	E069	-4117
chr19	17228400	17228486	E069	-4013
chr19	17235626	17235975	E069	3127
chr19	17244488	17244605	E069	11989
chr19	17244873	17245187	E069	12374
chr19	17245241	17245404	E069	12742
chr19	17245577	17245635	E069	13078
chr19	17245823	17247458	E069	13324
chr19	17245823	17247458	E070	13324
chr19	17189452	17189709	E071	-42790
chr19	17191768	17191818	E071	-40681
chr19	17191979	17192053	E071	-40446
chr19	17192214	17192268	E071	-40231
chr19	17192642	17193371	E071	-39128
chr19	17193460	17193500	E071	-38999
chr19	17193578	17193636	E071	-38863
chr19	17193687	17193799	E071	-38700
chr19	17193919	17193998	E071	-38501
chr19	17194016	17194091	E071	-38408
chr19	17194101	17194207	E071	-38292
chr19	17194217	17194304	E071	-38195
chr19	17194341	17194413	E071	-38086
chr19	17195796	17195931	E071	-36568
chr19	17195974	17196061	E071	-36438
chr19	17196074	17196195	E071	-36304
chr19	17196590	17196656	E071	-35843
chr19	17196706	17197216	E071	-35283
chr19	17197682	17197981	E071	-34518
chr19	17198025	17198226	E071	-34273
chr19	17198236	17198340	E071	-34159
chr19	17199114	17199178	E071	-33321
chr19	17199372	17199546	E071	-32953
chr19	17199629	17199802	E071	-32697
chr19	17199832	17201080	E071	-31419
chr19	17203391	17203463	E071	-29036
chr19	17203564	17203721	E071	-28778
chr19	17203748	17203809	E071	-28690
chr19	17205909	17206537	E071	-25962
chr19	17208319	17208382	E071	-24117
chr19	17208417	17208758	E071	-23741
chr19	17208888	17208932	E071	-23567
chr19	17209125	17209392	E071	-23107
chr19	17216356	17216430	E071	-16069
chr19	17216494	17216775	E071	-15724
chr19	17216854	17216912	E071	-15587
chr19	17216950	17217082	E071	-15417
chr19	17217118	17217320	E071	-15179
chr19	17217901	17218027	E071	-14472
chr19	17218108	17218196	E071	-14303
chr19	17218276	17219491	E071	-13008
chr19	17220379	17220482	E071	-12017
chr19	17220489	17221449	E071	-11050
chr19	17221451	17221516	E071	-10983
chr19	17221570	17221897	E071	-10602
chr19	17221934	17222043	E071	-10456
chr19	17222089	17222150	E071	-10349
chr19	17222426	17222505	E071	-9994
chr19	17222568	17222745	E071	-9754
chr19	17223042	17223096	E071	-9403
chr19	17223120	17223160	E071	-9339
chr19	17223190	17223259	E071	-9240
chr19	17223367	17223417	E071	-9082
chr19	17223517	17223935	E071	-8564
chr19	17223980	17224046	E071	-8453
chr19	17224129	17224196	E071	-8303
chr19	17224280	17224459	E071	-8040
chr19	17224652	17224726	E071	-7773
chr19	17224750	17224814	E071	-7685
chr19	17224875	17224963	E071	-7536
chr19	17225062	17225688	E071	-6811
chr19	17225851	17225891	E071	-6608
chr19	17225977	17226017	E071	-6482
chr19	17226685	17226857	E071	-5642
chr19	17226977	17227027	E071	-5472
chr19	17227078	17227176	E071	-5323
chr19	17227216	17227266	E071	-5233
chr19	17227681	17227747	E071	-4752
chr19	17227903	17227959	E071	-4540
chr19	17228082	17228172	E071	-4327
chr19	17228206	17228382	E071	-4117
chr19	17228400	17228486	E071	-4013
chr19	17228788	17229024	E071	-3475
chr19	17235626	17235975	E071	3127
chr19	17237718	17237826	E071	5219
chr19	17238044	17238180	E071	5545
chr19	17244873	17245187	E071	12374
chr19	17245241	17245404	E071	12742
chr19	17245577	17245635	E071	13078
chr19	17245823	17247458	E071	13324
chr19	17247468	17247730	E071	14969
chr19	17191768	17191818	E072	-40681
chr19	17192642	17193371	E072	-39128
chr19	17193460	17193500	E072	-38999
chr19	17193578	17193636	E072	-38863
chr19	17193687	17193799	E072	-38700
chr19	17193919	17193998	E072	-38501
chr19	17194016	17194091	E072	-38408
chr19	17194101	17194207	E072	-38292
chr19	17194217	17194304	E072	-38195
chr19	17194341	17194413	E072	-38086
chr19	17195796	17195931	E072	-36568
chr19	17195974	17196061	E072	-36438
chr19	17196074	17196195	E072	-36304
chr19	17197682	17197981	E072	-34518
chr19	17198025	17198226	E072	-34273
chr19	17198236	17198340	E072	-34159
chr19	17199372	17199546	E072	-32953
chr19	17199629	17199802	E072	-32697
chr19	17199832	17201080	E072	-31419
chr19	17202411	17203206	E072	-29293
chr19	17206918	17206976	E072	-25523
chr19	17206982	17207182	E072	-25317
chr19	17215430	17215486	E072	-17013
chr19	17215858	17215908	E072	-16591
chr19	17216356	17216430	E072	-16069
chr19	17216494	17216775	E072	-15724
chr19	17216854	17216912	E072	-15587
chr19	17216950	17217082	E072	-15417
chr19	17217118	17217320	E072	-15179
chr19	17217453	17217612	E072	-14887
chr19	17217901	17218027	E072	-14472
chr19	17218108	17218196	E072	-14303
chr19	17226685	17226857	E072	-5642
chr19	17226977	17227027	E072	-5472
chr19	17227078	17227176	E072	-5323
chr19	17227216	17227266	E072	-5233
chr19	17227681	17227747	E072	-4752
chr19	17227903	17227959	E072	-4540
chr19	17228082	17228172	E072	-4327
chr19	17228206	17228382	E072	-4117
chr19	17235626	17235975	E072	3127
chr19	17235980	17237467	E072	3481
chr19	17245577	17245635	E072	13078
chr19	17245823	17247458	E072	13324
chr19	17184221	17184271	E073	-48228
chr19	17184295	17184354	E073	-48145
chr19	17189452	17189709	E073	-42790
chr19	17189741	17189854	E073	-42645
chr19	17192642	17193371	E073	-39128
chr19	17193460	17193500	E073	-38999
chr19	17193578	17193636	E073	-38863
chr19	17193687	17193799	E073	-38700
chr19	17195796	17195931	E073	-36568
chr19	17195974	17196061	E073	-36438
chr19	17196074	17196195	E073	-36304
chr19	17197682	17197981	E073	-34518
chr19	17198025	17198226	E073	-34273
chr19	17198236	17198340	E073	-34159
chr19	17199114	17199178	E073	-33321
chr19	17199372	17199546	E073	-32953
chr19	17199629	17199802	E073	-32697
chr19	17199832	17201080	E073	-31419
chr19	17202411	17203206	E073	-29293
chr19	17208417	17208758	E073	-23741
chr19	17218276	17219491	E073	-13008
chr19	17226977	17227027	E073	-5472
chr19	17227078	17227176	E073	-5323
chr19	17227216	17227266	E073	-5233
chr19	17227681	17227747	E073	-4752
chr19	17227903	17227959	E073	-4540
chr19	17235980	17237467	E073	3481
chr19	17244873	17245187	E073	12374
chr19	17245241	17245404	E073	12742
chr19	17245577	17245635	E073	13078
chr19	17245823	17247458	E073	13324
chr19	17247468	17247730	E073	14969
chr19	17188658	17189123	E074	-43376
chr19	17189452	17189709	E074	-42790
chr19	17191554	17191614	E074	-40885
chr19	17191768	17191818	E074	-40681
chr19	17191979	17192053	E074	-40446
chr19	17192214	17192268	E074	-40231
chr19	17192642	17193371	E074	-39128
chr19	17193460	17193500	E074	-38999
chr19	17193578	17193636	E074	-38863
chr19	17193687	17193799	E074	-38700
chr19	17193919	17193998	E074	-38501
chr19	17194016	17194091	E074	-38408
chr19	17194101	17194207	E074	-38292
chr19	17194217	17194304	E074	-38195
chr19	17194341	17194413	E074	-38086
chr19	17195796	17195931	E074	-36568
chr19	17195974	17196061	E074	-36438
chr19	17196074	17196195	E074	-36304
chr19	17196590	17196656	E074	-35843
chr19	17196706	17197216	E074	-35283
chr19	17197682	17197981	E074	-34518
chr19	17198025	17198226	E074	-34273
chr19	17198236	17198340	E074	-34159
chr19	17199114	17199178	E074	-33321
chr19	17199372	17199546	E074	-32953
chr19	17199629	17199802	E074	-32697
chr19	17199832	17201080	E074	-31419
chr19	17202411	17203206	E074	-29293
chr19	17206918	17206976	E074	-25523
chr19	17206982	17207182	E074	-25317
chr19	17208417	17208758	E074	-23741
chr19	17216356	17216430	E074	-16069
chr19	17216494	17216775	E074	-15724
chr19	17217901	17218027	E074	-14472
chr19	17218108	17218196	E074	-14303
chr19	17218276	17219491	E074	-13008
chr19	17220489	17221449	E074	-11050
chr19	17221451	17221516	E074	-10983
chr19	17221570	17221897	E074	-10602
chr19	17224652	17224726	E074	-7773
chr19	17224750	17224814	E074	-7685
chr19	17224875	17224963	E074	-7536
chr19	17226685	17226857	E074	-5642
chr19	17226977	17227027	E074	-5472
chr19	17227078	17227176	E074	-5323
chr19	17227216	17227266	E074	-5233
chr19	17227681	17227747	E074	-4752
chr19	17227903	17227959	E074	-4540
chr19	17228082	17228172	E074	-4327
chr19	17228206	17228382	E074	-4117
chr19	17228400	17228486	E074	-4013
chr19	17228788	17229024	E074	-3475
chr19	17235980	17237467	E074	3481
chr19	17244873	17245187	E074	12374
chr19	17245241	17245404	E074	12742
chr19	17245577	17245635	E074	13078
chr19	17245823	17247458	E074	13324
chr19	17247468	17247730	E074	14969
chr19	17188658	17189123	E081	-43376
chr19	17189452	17189709	E081	-42790
chr19	17189741	17189854	E081	-42645
chr19	17199114	17199178	E081	-33321
chr19	17199372	17199546	E081	-32953
chr19	17199629	17199802	E081	-32697
chr19	17199832	17201080	E081	-31419
chr19	17201120	17202037	E081	-30462
chr19	17203391	17203463	E081	-29036
chr19	17235980	17237467	E081	3481
chr19	17245823	17247458	E081	13324
chr19	17247468	17247730	E081	14969
chr19	17235980	17237467	E082	3481

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr19	17184869	17188029	E067	-44470
chr19	17184869	17188029	E068	-44470
chr19	17184869	17188029	E069	-44470
chr19	17184869	17188029	E070	-44470
chr19	17184869	17188029	E071	-44470
chr19	17184869	17188029	E072	-44470
chr19	17184869	17188029	E073	-44470
chr19	17184869	17188029	E074	-44470
chr19	17184869	17188029	E082	-44470