rs11702690

Homo sapiens
A>G
ZBTB21 : 3 Prime UTR Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0058 (1755/29976,GnomAD)
G=0040 (1175/29118,TOPMED)
G=0032 (162/5008,1000G)
G=0064 (245/3854,ALSPAC)
G=0066 (243/3708,TWINSUK)
chr21:41987559 (GRCh38.p7) (21q22.3)
AD
GWASdb2
2   publication(s)
See rs on genome
180 Enhancers around
18 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 21NC_000021.9:g.41987559A>G
GRCh37.p13 chr 21NC_000021.8:g.43407668A>G

Gene: ZBTB21, zinc finger and BTB domain containing 21(minus strand)

Molecule type Change Amino acid[Codon] SO Term
ZBTB21 transcript variant 2NM_020727.4:c.N/A3 Prime UTR Variant
ZBTB21 transcript variant 1NM_001098402.1:c.N/A3 Prime UTR Variant
ZBTB21 transcript variant 3NM_001098403.1:c.N/A3 Prime UTR Variant
ZBTB21 transcript variant 5NM_001320731.1:c.N/A3 Prime UTR Variant
ZBTB21 transcript variant 4NM_001320729.1:c.N/A3 Prime UTR Variant
ZBTB21 transcript variant X1XM_017028360.1:c.N/A3 Prime UTR Variant
ZBTB21 transcript variant X2XM_011529588.2:c.N/A3 Prime UTR Variant
ZBTB21 transcript variant X3XM_011529590.2:c.N/A3 Prime UTR Variant
ZBTB21 transcript variant X4XM_017028361.1:c.N/A3 Prime UTR Variant
ZBTB21 transcript variant X5XM_005261121.3:c.N/A3 Prime UTR Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.996G=0.004
1000GenomesAmericanSub694A=0.960G=0.040
1000GenomesEast AsianSub1008A=0.990G=0.010
1000GenomesEuropeSub1006A=0.929G=0.071
1000GenomesGlobalStudy-wide5008A=0.968G=0.032
1000GenomesSouth AsianSub978A=0.950G=0.050
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.936G=0.064
The Genome Aggregation DatabaseAfricanSub8734A=0.985G=0.015
The Genome Aggregation DatabaseAmericanSub836A=0.970G=0.030
The Genome Aggregation DatabaseEast AsianSub1620A=0.994G=0.006
The Genome Aggregation DatabaseEuropeSub18484A=0.915G=0.084
The Genome Aggregation DatabaseGlobalStudy-wide29976A=0.941G=0.058
The Genome Aggregation DatabaseOtherSub302A=0.940G=0.060
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.959G=0.040
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.934G=0.066
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res
19581569Genome-wide association study of alcohol dependence.Treutlein JArch Gen Psychiatry

P-Value

SNP ID p-value Traits Study
rs117026904.79E-05alcohol dependence19581569

eQTL of rs11702690 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs11702690 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr214336362643363681E067-43987
chr214336372243363890E067-43778
chr214336396743364007E067-43661
chr214336409843364280E067-43388
chr214336783543368937E067-38731
chr214336906443369114E067-38554
chr214336921943369274E067-38394
chr214336930243369356E067-38312
chr214336947243369522E067-38146
chr214337185443371920E067-35748
chr214337197143372331E067-35337
chr214337516743375395E067-32273
chr214337716343379065E067-28603
chr214342739643427545E06719728
chr214342757743427907E06719909
chr214336362643363681E068-43987
chr214336372243363890E068-43778
chr214336396743364007E068-43661
chr214336409843364280E068-43388
chr214336686343366973E068-40695
chr214336761043367672E068-39996
chr214336906443369114E068-38554
chr214336921943369274E068-38394
chr214336930243369356E068-38312
chr214337716343379065E068-28603
chr214338989643390219E068-17449
chr214339025743390398E068-17270
chr214342873043428933E06821062
chr214344153943441691E06833871
chr214344185243442807E06834184
chr214336362643363681E069-43987
chr214336372243363890E069-43778
chr214336396743364007E069-43661
chr214336409843364280E069-43388
chr214336476543364809E069-42859
chr214336686343366973E069-40695
chr214336761043367672E069-39996
chr214336906443369114E069-38554
chr214336921943369274E069-38394
chr214336930243369356E069-38312
chr214336947243369522E069-38146
chr214337068543370781E069-36887
chr214337086343370982E069-36686
chr214337103843371499E069-36169
chr214337155843371700E069-35968
chr214337185443371920E069-35748
chr214337197143372331E069-35337
chr214337716343379065E069-28603
chr214340499443405068E069-2600
chr214340511243405189E069-2479
chr214344185243442807E06934184
chr214344763643448471E06939968
chr214336783543368937E070-38731
chr214337494843375041E070-32627
chr214342873043428933E07021062
chr214344153943441691E07033871
chr214344185243442807E07034184
chr214336216543362272E071-45396
chr214336278843362832E071-44836
chr214336332943363379E071-44289
chr214336362643363681E071-43987
chr214336686343366973E071-40695
chr214336761043367672E071-39996
chr214336783543368937E071-38731
chr214336906443369114E071-38554
chr214336921943369274E071-38394
chr214336930243369356E071-38312
chr214337155843371700E071-35968
chr214337185443371920E071-35748
chr214337197143372331E071-35337
chr214337716343379065E071-28603
chr214338129543381851E071-25817
chr214338191643382061E071-25607
chr214338212343382427E071-25241
chr214338989643390219E071-17449
chr214339025743390398E071-17270
chr214344153943441691E07133871
chr214344185243442807E07134184
chr214345197043452067E07144302
chr214345207843452185E07144410
chr214336332943363379E072-44289
chr214336362643363681E072-43987
chr214336372243363890E072-43778
chr214336396743364007E072-43661
chr214336409843364280E072-43388
chr214336761043367672E072-39996
chr214336906443369114E072-38554
chr214336921943369274E072-38394
chr214336930243369356E072-38312
chr214336947243369522E072-38146
chr214337155843371700E072-35968
chr214337185443371920E072-35748
chr214337197143372331E072-35337
chr214337716343379065E072-28603
chr214342816543428223E07220497
chr214342853943428633E07220871
chr214342873043428933E07221062
chr214344153943441691E07233871
chr214344756243447616E07239894
chr214344763643448471E07239968
chr214344865143449010E07240983
chr214336332943363379E073-44289
chr214336362643363681E073-43987
chr214336372243363890E073-43778
chr214336396743364007E073-43661
chr214336409843364280E073-43388
chr214336783543368937E073-38731
chr214336906443369114E073-38554
chr214336921943369274E073-38394
chr214336930243369356E073-38312
chr214337197143372331E073-35337
chr214337716343379065E073-28603
chr214338989643390219E073-17449
chr214339025743390398E073-17270
chr214344153943441691E07333871
chr214344185243442807E07334184
chr214344865143449010E07340983
chr214336332943363379E074-44289
chr214336362643363681E074-43987
chr214336372243363890E074-43778
chr214336396743364007E074-43661
chr214336409843364280E074-43388
chr214336476543364809E074-42859
chr214336525443365409E074-42259
chr214336623043366315E074-41353
chr214336644943366537E074-41131
chr214336656443366742E074-40926
chr214336686343366973E074-40695
chr214336761043367672E074-39996
chr214336783543368937E074-38731
chr214336906443369114E074-38554
chr214336921943369274E074-38394
chr214336930243369356E074-38312
chr214336947243369522E074-38146
chr214337068543370781E074-36887
chr214337086343370982E074-36686
chr214337103843371499E074-36169
chr214337155843371700E074-35968
chr214337185443371920E074-35748
chr214337197143372331E074-35337
chr214337716343379065E074-28603
chr214338191643382061E074-25607
chr214338212343382427E074-25241
chr214338989643390219E074-17449
chr214339025743390398E074-17270
chr214344153943441691E07433871
chr214337494843375041E081-32627
chr214337516743375395E081-32273
chr214337716343379065E081-28603
chr214342873043428933E08121062
chr214343183043432012E08124162
chr214343203643432144E08124368
chr214343219843432268E08124530
chr214343231143433107E08124643
chr214343315243433250E08125484
chr214344153943441691E08133871
chr214344185243442807E08134184
chr214344633343446497E08138665
chr214344654143446659E08138873
chr214344692843447073E08139260
chr214344713343447439E08139465
chr214344744943447503E08139781
chr214344756243447616E08139894
chr214344763643448471E08139968
chr214344865143449010E08140983
chr214344905443449918E08141386
chr214337103843371499E082-36169
chr214337197143372331E082-35337
chr214343183043432012E08224162
chr214343203643432144E08224368
chr214343219843432268E08224530
chr214343231143433107E08224643
chr214343315243433250E08225484
chr214344124543441295E08233577
chr214344133643441386E08233668
chr214344153943441691E08233871
chr214344185243442807E08234184
chr214344756243447616E08239894
chr214344763643448471E08239968
chr214344905443449918E08241386










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr214337242243374943E067-32725
chr214342893643431647E06721268
chr214337242243374943E068-32725
chr214342893643431647E06821268
chr214337242243374943E069-32725
chr214342893643431647E06921268
chr214337242243374943E070-32725
chr214342893643431647E07021268
chr214337242243374943E071-32725
chr214342893643431647E07121268
chr214337242243374943E072-32725
chr214342893643431647E07221268
chr214337242243374943E073-32725
chr214342893643431647E07321268
chr214337242243374943E074-32725
chr214342893643431647E07421268
chr214337242243374943E082-32725
chr214342893643431647E08221268