rs11707074

Homo sapiens
C>T
TATDN2 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0234 (7006/29934,GnomAD)
T=0211 (6144/29118,TOPMED)
T=0218 (1090/5008,1000G)
T=0290 (1117/3854,ALSPAC)
T=0294 (1090/3708,TWINSUK)
chr3:10250959 (GRCh38.p7) (3p25.3)
AD
GWASdb2
1   publication(s)
See rs on genome
63 Enhancers around
10 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.10250959C>T
GRCh37.p13 chr 3NC_000003.11:g.10292643C>T

Gene: TATDN2, TatD DNase domain containing 2(plus strand)

Molecule type Change Amino acid[Codon] SO Term
TATDN2 transcriptNM_014760.3:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.915T=0.085
1000GenomesAmericanSub694C=0.820T=0.180
1000GenomesEast AsianSub1008C=0.737T=0.263
1000GenomesEuropeSub1006C=0.667T=0.333
1000GenomesGlobalStudy-wide5008C=0.782T=0.218
1000GenomesSouth AsianSub978C=0.740T=0.260
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.710T=0.290
The Genome Aggregation DatabaseAfricanSub8720C=0.897T=0.103
The Genome Aggregation DatabaseAmericanSub838C=0.830T=0.170
The Genome Aggregation DatabaseEast AsianSub1614C=0.739T=0.261
The Genome Aggregation DatabaseEuropeSub18462C=0.705T=0.294
The Genome Aggregation DatabaseGlobalStudy-wide29934C=0.766T=0.234
The Genome Aggregation DatabaseOtherSub300C=0.640T=0.360
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.789T=0.211
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.706T=0.294
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs117070740.000712alcohol dependence21314694

eQTL of rs11707074 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr3:10292643GHRLOSENSG00000240288.3C>T1.4631e-9-36455Cerebellum

meQTL of rs11707074 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr31024671710248189E067-44454
chr31024819110248241E067-44402
chr31026647310267270E067-25373
chr31031482410314874E06722181
chr31031553810315630E06722895
chr31032620310326594E06733560
chr31032673410326985E06734091
chr31032748610327538E06734843
chr31032761210327719E06734969
chr31032780110327855E06735158
chr31032795910328053E06735316
chr31032844610328502E06735803
chr31032850310328613E06735860
chr31032863110328929E06735988
chr31034143910341673E06748796
chr31034197310342023E06749330
chr31034219110342248E06749548
chr31034237410342424E06749731
chr31024671710248189E068-44454
chr31026647310267270E068-25373
chr31031482410314874E06822181
chr31031553810315630E06822895
chr31032863110328929E06835988
chr31032901210329100E06836369
chr31032968310329743E06837040
chr31032990810329948E06837265
chr31024671710248189E069-44454
chr31024819110248241E069-44402
chr31026647310267270E069-25373
chr31031482410314874E06922181
chr31031553810315630E06922895
chr31031576710315876E06923124
chr31032863110328929E06935988
chr31032901210329100E06936369
chr31024671710248189E071-44454
chr31024819110248241E071-44402
chr31024671710248189E072-44454
chr31024819110248241E072-44402
chr31026647310267270E072-25373
chr31031482410314874E07222181
chr31031553810315630E07222895
chr31031576710315876E07223124
chr31032673410326985E07234091
chr31032850310328613E07235860
chr31032863110328929E07235988
chr31032901210329100E07236369
chr31026647310267270E073-25373
chr31029554510295673E0732902
chr31029570510295746E0733062
chr31029574910295803E0733106
chr31031482410314874E07322181
chr31032673410326985E07334091
chr31032844610328502E07335803
chr31032850310328613E07335860
chr31032863110328929E07335988
chr31032901210329100E07336369
chr31024671710248189E074-44454
chr31024819110248241E074-44402
chr31026647310267270E074-25373
chr31031482410314874E07422181
chr31031553810315630E07422895
chr31031576710315876E07423124
chr31031633610316652E07423693







Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr31028949010291787E067-856
chr31028949010291787E068-856
chr31028949010291787E069-856
chr31028949010291787E070-856
chr31028949010291787E071-856
chr31028949010291787E072-856
chr31028949010291787E073-856
chr31028949010291787E074-856
chr31028949010291787E081-856
chr31028949010291787E082-856