rs11732375

Homo sapiens
G>A
RGS12 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0186 (5537/29626,GnomAD)
A=0207 (6031/29118,TOPMED)
A=0264 (1323/5008,1000G)
A=0160 (615/3854,ALSPAC)
A=0157 (581/3708,TWINSUK)
chr4:3395236 (GRCh38.p7) (4p16.3)
AD
GWASdb2
1   publication(s)
See rs on genome
205 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.3395236G>A
GRCh37.p13 chr 4NC_000004.11:g.3396963G>A
RGS12 RefSeqGeneNG_029903.1:g.86090G>A

Gene: RGS12, regulator of G-protein signaling 12(plus strand)

Molecule type Change Amino acid[Codon] SO Term
RGS12 transcript variant 2NM_002926.3:c.N/AIntron Variant
RGS12 transcript variant 3NM_198227.1:c.N/AIntron Variant
RGS12 transcript variant 1NM_198229.2:c.N/AIntron Variant
RGS12 transcript variant X1XM_006713905.1:c.N/AIntron Variant
RGS12 transcript variant X3XM_006713906.2:c.N/AIntron Variant
RGS12 transcript variant X8XM_006713907.1:c.N/AIntron Variant
RGS12 transcript variant X9XM_011513543.2:c.N/AIntron Variant
RGS12 transcript variant X2XM_017008529.1:c.N/AIntron Variant
RGS12 transcript variant X9XM_017008531.1:c.N/AIntron Variant
RGS12 transcript variant X11XM_017008532.1:c.N/AIntron Variant
RGS12 transcript variant X12XM_017008533.1:c.N/AIntron Variant
RGS12 transcript variant X13XM_017008534.1:c.N/AIntron Variant
RGS12 transcript variant X7XM_017008530.1:c.N/AGenic Downstream Transcript Variant
RGS12 transcript variant X5XR_427479.2:n.N/AIntron Variant
RGS12 transcript variant X6XR_924987.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.734A=0.266
1000GenomesAmericanSub694G=0.730A=0.270
1000GenomesEast AsianSub1008G=0.805A=0.195
1000GenomesEuropeSub1006G=0.847A=0.153
1000GenomesGlobalStudy-wide5008G=0.736A=0.264
1000GenomesSouth AsianSub978G=0.560A=0.440
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.840A=0.160
The Genome Aggregation DatabaseAfricanSub8648G=0.748A=0.252
The Genome Aggregation DatabaseAmericanSub830G=0.730A=0.270
The Genome Aggregation DatabaseEast AsianSub1612G=0.791A=0.209
The Genome Aggregation DatabaseEuropeSub18234G=0.853A=0.147
The Genome Aggregation DatabaseGlobalStudy-wide29626G=0.813A=0.186
The Genome Aggregation DatabaseOtherSub302G=0.610A=0.390
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.792A=0.207
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.843A=0.157
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs117323750.000648alcohol dependence20201924

eQTL of rs11732375 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs11732375 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr433705923370695E067-26268
chr433707093370766E067-26197
chr433888723389014E067-7949
chr433891663389269E067-7694
chr433893483390285E067-6678
chr434158383416028E06718875
chr434162403416454E06719277
chr433537003354121E068-42842
chr433543733354552E068-42411
chr433662173366265E068-30698
chr433662713366334E068-30629
chr433664803366560E068-30403
chr433705923370695E068-26268
chr433707093370766E068-26197
chr433744093374583E068-22380
chr433746933374976E068-21987
chr433775043377761E068-19202
chr433861603388679E068-8284
chr433915633391626E068-5337
chr433920673392166E068-4797
chr433923633392559E068-4404
chr434014503401500E0684487
chr434016393401814E0684676
chr434081773408227E06811214
chr434088463409153E06811883
chr434104743410735E06813511
chr434108613410911E06813898
chr434142233414317E06817260
chr434150273415356E06818064
chr434155273415677E06818564
chr434157453415799E06818782
chr434158383416028E06818875
chr434162403416454E06819277
chr434165253417011E06819562
chr434170753417393E06820112
chr434382093438269E06841246
chr434383283438513E06841365
chr434385853439153E06841622
chr433478453348247E069-48716
chr433662173366265E069-30698
chr433662713366334E069-30629
chr433705923370695E069-26268
chr433707093370766E069-26197
chr433746933374976E069-21987
chr433888723389014E069-7949
chr433891663389269E069-7694
chr433893483390285E069-6678
chr433903693391192E069-5771
chr433915633391626E069-5337
chr434081773408227E06911214
chr434088463409153E06911883
chr434150273415356E06918064
chr434155273415677E06918564
chr434157453415799E06918782
chr434158383416028E06918875
chr434162403416454E06919277
chr434165253417011E06919562
chr433537003354121E070-42842
chr433648343364884E070-32079
chr433651063365240E070-31723
chr433653483365427E070-31536
chr433654703365635E070-31328
chr433656443365784E070-31179
chr433662173366265E070-30698
chr433662713366334E070-30629
chr433664803366560E070-30403
chr433686803368754E070-28209
chr433688103369160E070-27803
chr433695363369592E070-27371
chr433728063373537E070-23426
chr433744093374583E070-22380
chr433746933374976E070-21987
chr433888723389014E070-7949
chr433891663389269E070-7694
chr433893483390285E070-6678
chr433903693391192E070-5771
chr433915633391626E070-5337
chr433920673392166E070-4797
chr433923633392559E070-4404
chr434088463409153E07011883
chr434104743410735E07013511
chr434116623411742E07014699
chr434121203412233E07015157
chr434124103412490E07015447
chr433478453348247E071-48716
chr433537003354121E071-42842
chr433656443365784E071-31179
chr433662173366265E071-30698
chr433662713366334E071-30629
chr433664803366560E071-30403
chr433695363369592E071-27371
chr433705923370695E071-26268
chr433707093370766E071-26197
chr433744093374583E071-22380
chr433746933374976E071-21987
chr433760913376131E071-20832
chr433888723389014E071-7949
chr433891663389269E071-7694
chr433920673392166E071-4797
chr434142233414317E07117260
chr434150273415356E07118064
chr434155273415677E07118564
chr434157453415799E07118782
chr434158383416028E07118875
chr434162403416454E07119277
chr434165253417011E07119562
chr434415063441581E07144543
chr434419363442019E07144973
chr433478453348247E072-48716
chr433705923370695E072-26268
chr433707093370766E072-26197
chr433744093374583E072-22380
chr433888723389014E072-7949
chr433891663389269E072-7694
chr434041293404355E0727166
chr434043573404495E0727394
chr434045333404915E0727570
chr434142233414317E07217260
chr434150273415356E07218064
chr434155273415677E07218564
chr434165253417011E07219562
chr434170753417393E07220112
chr434234323423554E07226469
chr433705923370695E073-26268
chr433707093370766E073-26197
chr433740123374106E073-22857
chr433744093374583E073-22380
chr433746933374976E073-21987
chr433760913376131E073-20832
chr433861603388679E073-8284
chr433903693391192E073-5771
chr434081773408227E07311214
chr434142233414317E07317260
chr434155273415677E07318564
chr434157453415799E07318782
chr434158383416028E07318875
chr434170753417393E07320112
chr433705923370695E074-26268
chr433707093370766E074-26197
chr433728063373537E074-23426
chr433736013373755E074-23208
chr433888723389014E074-7949
chr433891663389269E074-7694
chr433893483390285E074-6678
chr434142233414317E07417260
chr434150273415356E07418064
chr434155273415677E07418564
chr434157453415799E07418782
chr434158383416028E07418875
chr434451333445593E07448170
chr433478453348247E081-48716
chr433603563360416E081-36547
chr433605073360693E081-36270
chr433608433360898E081-36065
chr433648343364884E081-32079
chr433651063365240E081-31723
chr433653483365427E081-31536
chr433654703365635E081-31328
chr433656443365784E081-31179
chr433671293367207E081-29756
chr433686803368754E081-28209
chr433688103369160E081-27803
chr433695363369592E081-27371
chr433705923370695E081-26268
chr433707093370766E081-26197
chr433736013373755E081-23208
chr433740123374106E081-22857
chr433888723389014E081-7949
chr433891663389269E081-7694
chr433893483390285E081-6678
chr433903693391192E081-5771
chr433915633391626E081-5337
chr434081773408227E08111214
chr434088463409153E08111883
chr434116623411742E08114699
chr434121203412233E08115157
chr434124103412490E08115447
chr434150273415356E08118064
chr434155273415677E08118564
chr434157453415799E08118782
chr434158383416028E08118875
chr434162403416454E08119277
chr434165253417011E08119562
chr434170753417393E08120112
chr433648343364884E082-32079
chr433651063365240E082-31723
chr433653483365427E082-31536
chr433654703365635E082-31328
chr433656443365784E082-31179
chr433686803368754E082-28209
chr433688103369160E082-27803
chr433695363369592E082-27371
chr433740123374106E082-22857
chr433744093374583E082-22380
chr433746933374976E082-21987
chr433893483390285E082-6678
chr433903693391192E082-5771
chr434081773408227E08211214
chr434088463409153E08211883
chr434108613410911E08213898
chr434116623411742E08214699
chr434121203412233E08215157
chr434124103412490E08215447
chr434362493436303E08239286
chr434364003436454E08239437