rs11770536

Homo sapiens
T>C
PDE1C : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T==0432 (12930/29898,GnomAD)
T==0448 (13062/29118,TOPMED)
C=0467 (2337/5008,1000G)
T==0409 (1575/3854,ALSPAC)
T==0437 (1619/3708,TWINSUK)
chr7:31934361 (GRCh38.p7) (7p14.3)
ND
GWASdb2
1   publication(s)
See rs on genome
233 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.31934361T>C
GRCh37.p13 chr 7NC_000007.13:g.31973974T>C

Gene: PDE1C, phosphodiesterase 1C(minus strand)

Molecule type Change Amino acid[Codon] SO Term
PDE1C transcript variant 1NM_001191056.3:c.N/AIntron Variant
PDE1C transcript variant 2NM_001191057.3:c.N/AIntron Variant
PDE1C transcript variant 3NM_001191058.3:c.N/AIntron Variant
PDE1C transcript variant 5NM_001191059.3:c.N/AIntron Variant
PDE1C transcript variant 6NM_001322055.1:c.N/AIntron Variant
PDE1C transcript variant 7NM_001322056.1:c.N/AIntron Variant
PDE1C transcript variant 8NM_001322057.1:c.N/AIntron Variant
PDE1C transcript variant 9NM_001322058.1:c.N/AIntron Variant
PDE1C transcript variant 10NM_001322059.1:c.N/AIntron Variant
PDE1C transcript variant 4NM_005020.4:c.N/AIntron Variant
PDE1C transcript variant X1XM_017012264.1:c.N/AIntron Variant
PDE1C transcript variant X4XM_017012265.1:c.N/AIntron Variant
PDE1C transcript variant X5XM_017012266.1:c.N/AIntron Variant
PDE1C transcript variant X6XM_017012267.1:c.N/AIntron Variant
PDE1C transcript variant X2XR_001744802.1:n.N/AIntron Variant
PDE1C transcript variant X3XR_001744803.1:n.N/AIntron Variant
PDE1C transcript variant X7XR_001744804.1:n.N/AIntron Variant
PDE1C transcript variant X8XR_001744805.1:n.N/AIntron Variant
PDE1C transcript variant X9XR_001744806.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.470C=0.530
1000GenomesAmericanSub694T=0.530C=0.470
1000GenomesEast AsianSub1008T=0.583C=0.417
1000GenomesEuropeSub1006T=0.448C=0.552
1000GenomesGlobalStudy-wide5008T=0.533C=0.467
1000GenomesSouth AsianSub978T=0.660C=0.340
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.409C=0.591
The Genome Aggregation DatabaseAfricanSub8704T=0.456C=0.544
The Genome Aggregation DatabaseAmericanSub834T=0.490C=0.510
The Genome Aggregation DatabaseEast AsianSub1606T=0.526C=0.474
The Genome Aggregation DatabaseEuropeSub18454T=0.408C=0.591
The Genome Aggregation DatabaseGlobalStudy-wide29898T=0.432C=0.567
The Genome Aggregation DatabaseOtherSub300T=0.560C=0.440
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.448C=0.551
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.437C=0.563
PMID Title Author Journal
20158304A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.Lind PATwin Res Hum Genet

P-Value

SNP ID p-value Traits Study
rs117705365.45E-05alcohol and nictotine co-dependence20158304

eQTL of rs11770536 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs11770536 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr73192440831924777E067-49197
chr73192488631925205E067-48769
chr73192544631925579E067-48395
chr73192580231926325E067-47649
chr73193595431936014E067-37960
chr73193605931936109E067-37865
chr73193612431936207E067-37767
chr73193624431936304E067-37670
chr73193650031936630E067-37344
chr73193665531936738E067-37236
chr73195275231952807E067-21167
chr73195287331952937E067-21037
chr73196402831964202E067-9772
chr73196426231964368E067-9606
chr73197370731973839E067-135
chr73197436431974444E067390
chr73197467731974770E067703
chr73197481031975159E067836
chr73199599431996408E06722020
chr73199680531997004E06722831
chr73199703531997288E06723061
chr73199747231997884E06723498
chr73193476031934810E068-39164
chr73193488331934933E068-39041
chr73193502331935105E068-38869
chr73193531331935400E068-38574
chr73193557631935721E068-38253
chr73193650031936630E068-37344
chr73193665531936738E068-37236
chr73197481031975159E068836
chr73199680531997004E06822831
chr73199703531997288E06823061
chr73202267732022806E06848703
chr73202294332023046E06848969
chr73202349532023581E06849521
chr73202372232023772E06849748
chr73192440831924777E069-49197
chr73192488631925205E069-48769
chr73192912831929250E069-44724
chr73192930131929351E069-44623
chr73192979531930276E069-43698
chr73193051731930716E069-43258
chr73193073431930864E069-43110
chr73193165131931701E069-42273
chr73193178731931828E069-42146
chr73193183831931940E069-42034
chr73193211031932160E069-41814
chr73193322031933457E069-40517
chr73193361731933703E069-40271
chr73193379531933845E069-40129
chr73193398831934251E069-39723
chr73193439231934487E069-39487
chr73193476031934810E069-39164
chr73196402831964202E069-9772
chr73196426231964368E069-9606
chr73197325331973397E069-577
chr73197370731973839E069-135
chr73197436431974444E069390
chr73197467731974770E069703
chr73197481031975159E069836
chr73197540331975743E0691429
chr73197598931976039E0692015
chr73197622031976507E0692246
chr73199295731993007E06918983
chr73199320831993320E06919234
chr73199371131993761E06919737
chr73199394131994053E06919967
chr73199680531997004E06922831
chr73199703531997288E06923061
chr73199747231997884E06923498
chr73199790531998137E06923931
chr73193322031933457E070-40517
chr73193361731933703E070-40271
chr73193379531933845E070-40129
chr73192440831924777E071-49197
chr73192488631925205E071-48769
chr73192544631925579E071-48395
chr73192580231926325E071-47649
chr73192645831926514E071-47460
chr73192696031927047E071-46927
chr73192709431927144E071-46830
chr73192880331928880E071-45094
chr73192890231928987E071-44987
chr73192912831929250E071-44724
chr73192930131929351E071-44623
chr73192979531930276E071-43698
chr73193051731930716E071-43258
chr73193073431930864E071-43110
chr73193165131931701E071-42273
chr73193178731931828E071-42146
chr73193183831931940E071-42034
chr73193211031932160E071-41814
chr73193230531932475E071-41499
chr73193276331932813E071-41161
chr73193322031933457E071-40517
chr73193361731933703E071-40271
chr73193379531933845E071-40129
chr73193398831934251E071-39723
chr73193439231934487E071-39487
chr73193476031934810E071-39164
chr73193557631935721E071-38253
chr73193665531936738E071-37236
chr73193878831938875E071-35099
chr73193902431939138E071-34836
chr73195456331954613E071-19361
chr73195495631955006E071-18968
chr73195501931955102E071-18872
chr73196315131963201E071-10773
chr73196331031963350E071-10624
chr73196337131963439E071-10535
chr73196402831964202E071-9772
chr73196426231964368E071-9606
chr73196448131965020E071-8954
chr73197436431974444E071390
chr73197467731974770E071703
chr73197481031975159E071836
chr73197540331975743E0711429
chr73197598931976039E0712015
chr73197622031976507E0712246
chr73197663131976728E0712657
chr73197682931976879E0712855
chr73197707131977310E0713097
chr73197983131979881E0715857
chr73197994431980090E0715970
chr73198015631980227E0716182
chr73198172431981778E0717750
chr73198380331983866E0719829
chr73199320831993320E07119234
chr73199371131993761E07119737
chr73199394131994053E07119967
chr73199484131994907E07120867
chr73199680531997004E07122831
chr73199703531997288E07123061
chr73199747231997884E07123498
chr73199790531998137E07123931
chr73202148632021839E07147512
chr73202246632022522E07148492
chr73202267732022806E07148703
chr73202294332023046E07148969
chr73202349532023581E07149521
chr73192488631925205E072-48769
chr73193178731931828E072-42146
chr73193183831931940E072-42034
chr73193211031932160E072-41814
chr73193322031933457E072-40517
chr73193361731933703E072-40271
chr73193379531933845E072-40129
chr73194378631943836E072-30138
chr73195321031953280E072-20694
chr73195336331953591E072-20383
chr73197481031975159E072836
chr73197540331975743E0721429
chr73198380331983866E0729829
chr73199371131993761E07219737
chr73199484131994907E07220867
chr73199539631995511E07221422
chr73199680531997004E07222831
chr73199703531997288E07223061
chr73199747231997884E07223498
chr73199790531998137E07223931
chr73201205732012107E07238083
chr73193322031933457E073-40517
chr73193361731933703E073-40271
chr73193379531933845E073-40129
chr73193398831934251E073-39723
chr73199680531997004E07322831
chr73199703531997288E07323061
chr73192440831924777E074-49197
chr73192488631925205E074-48769
chr73192544631925579E074-48395
chr73192580231926325E074-47649
chr73192645831926514E074-47460
chr73192696031927047E074-46927
chr73192709431927144E074-46830
chr73193051731930716E074-43258
chr73193073431930864E074-43110
chr73193165131931701E074-42273
chr73193178731931828E074-42146
chr73193183831931940E074-42034
chr73193211031932160E074-41814
chr73193230531932475E074-41499
chr73193276331932813E074-41161
chr73193398831934251E074-39723
chr73193439231934487E074-39487
chr73193476031934810E074-39164
chr73193488331934933E074-39041
chr73194648731946756E074-27218
chr73195456331954613E074-19361
chr73195495631955006E074-18968
chr73195501931955102E074-18872
chr73196213631962876E074-11098
chr73196402831964202E074-9772
chr73196426231964368E074-9606
chr73197467731974770E074703
chr73197481031975159E074836
chr73197540331975743E0741429
chr73197598931976039E0742015
chr73197622031976507E0742246
chr73197663131976728E0742657
chr73197682931976879E0742855
chr73197828531978653E0744311
chr73197873531978999E0744761
chr73197930831979364E0745334
chr73197983131979881E0745857
chr73197994431980090E0745970
chr73198015631980227E0746182
chr73198054031980584E0746566
chr73198172431981778E0747750
chr73199371131993761E07419737
chr73199394131994053E07419967
chr73199414331994354E07420169
chr73199599431996408E07422020
chr73199680531997004E07422831
chr73199703531997288E07423061
chr73199747231997884E07423498
chr73202148632021839E07447512
chr73202267732022806E07448703
chr73202294332023046E07448969
chr73193361731933703E081-40271
chr73193379531933845E081-40129
chr73193398831934251E081-39723
chr73193439231934487E081-39487
chr73193476031934810E081-39164
chr73193488331934933E081-39041
chr73195275231952807E081-21167
chr73195287331952937E081-21037
chr73196213631962876E081-11098
chr73196315131963201E081-10773
chr73196402831964202E081-9772
chr73196426231964368E081-9606
chr73196448131965020E081-8954
chr73199989431999969E08125920
chr73200048432000740E08126510