rs1177825

Homo sapiens
C>T
LOC107985340 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0233 (6946/29794,GnomAD)
T=0221 (6460/29118,TOPMED)
T=0174 (871/5008,1000G)
T=0267 (1028/3854,ALSPAC)
T=0260 (964/3708,TWINSUK)
chr19:49235225 (GRCh38.p7) (19q13.33)
AD
GWASdb2
1   publication(s)
See rs on genome
12 Enhancers around
12 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 19NC_000019.10:g.49235225C>T
GRCh37.p13 chr 19NC_000019.9:g.49738482C>T

Gene: LOC107985340, uncharacterized LOC107985340(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC107985340 transcriptXR_001753971.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.815T=0.185
1000GenomesAmericanSub694C=0.800T=0.200
1000GenomesEast AsianSub1008C=0.931T=0.069
1000GenomesEuropeSub1006C=0.726T=0.274
1000GenomesGlobalStudy-wide5008C=0.826T=0.174
1000GenomesSouth AsianSub978C=0.860T=0.140
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.733T=0.267
The Genome Aggregation DatabaseAfricanSub8672C=0.793T=0.207
The Genome Aggregation DatabaseAmericanSub836C=0.800T=0.200
The Genome Aggregation DatabaseEast AsianSub1606C=0.922T=0.078
The Genome Aggregation DatabaseEuropeSub18378C=0.738T=0.261
The Genome Aggregation DatabaseGlobalStudy-wide29794C=0.766T=0.233
The Genome Aggregation DatabaseOtherSub302C=0.830T=0.170
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.778T=0.221
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.740T=0.260
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs11778250.000485alcohol dependence20201924

eQTL of rs1177825 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1177825 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr194970025749700366E069-38116
chr194972916749729214E069-9268
chr194972925149729717E069-8765
chr194971488149714939E070-23543
chr194969986949700156E071-38326
chr194969986949700156E073-38326
chr194970025749700366E073-38116
chr194978751649787566E07449034
chr194971488149714939E081-23543
chr194971496949715827E081-22655
chr194971488149714939E082-23543
chr194971496949715827E082-22655







Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr194971100749711567E067-26915
chr194971159049711864E067-26618
chr194971159049711864E068-26618
chr194971159049711864E069-26618
chr194971324749714444E070-24038
chr194971159049711864E071-26618
chr194971100749711567E072-26915
chr194971159049711864E072-26618
chr194971159049711864E073-26618
chr194971100749711567E074-26915
chr194971159049711864E074-26618
chr194971324749714444E074-24038