SNP Detail Info-rs11781492

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A=0108 (3243/29960,GnomAD)
A=0119 (3482/29118,TOPMED)
A=0058 (291/5008,1000G)
A=0165 (637/3854,ALSPAC)
A=0177 (655/3708,TWINSUK)

Position: chr8:111086064 (GRCh38.p7) (8q23.2)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 6 Enhancers around

Promoter: 0 Promoter around

Sequence Name	Change(s)
GRCh38.p7 chr 8	NC_000008.11:g.111086064G>A
GRCh37.p13 chr 8	NC_000008.10:g.112098293G>A

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.997	A=0.003
1000Genomes	American	Sub	694	G=0.930	A=0.070
1000Genomes	East Asian	Sub	1008	G=0.999	A=0.001
1000Genomes	Europe	Sub	1006	G=0.835	A=0.165
1000Genomes	Global	Study-wide	5008	G=0.942	A=0.058
1000Genomes	South Asian	Sub	978	G=0.930	A=0.070
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.835	A=0.165
The Genome Aggregation Database	African	Sub	8722	G=0.969	A=0.031
The Genome Aggregation Database	American	Sub	836	G=0.910	A=0.090
The Genome Aggregation Database	East Asian	Sub	1616	G=0.999	A=0.001
The Genome Aggregation Database	Europe	Sub	18484	G=0.845	A=0.154
The Genome Aggregation Database	Global	Study-wide	29960	G=0.891	A=0.108
The Genome Aggregation Database	Other	Sub	302	G=0.840	A=0.160
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.880	A=0.119
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.823	A=0.177

PMID	Title	Author	Journal
20201924	Genome-wide association study of alcohol dependence implicates a region on chromosome 11.	Edenberg HJ	Alcohol Clin Exp Res

SNP ID	p-value	Traits	Study
rs11781492	0.00042	Alcohol dependence (early age of onset)	20201924
rs11781492	0.00065	alcohol dependence	20201924

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr8	112055949	112056246	E067	-42047
chr8	112056249	112056342	E067	-41951
chr8	112055949	112056246	E069	-42047
chr8	112056249	112056342	E069	-41951
chr8	112135874	112136065	E071	37581
chr8	112056445	112056497	E072	-41796

rs11781492