rs11845765

Homo sapiens
T>G
SGPP1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0044 (1335/29760,GnomAD)
G=0060 (1757/29118,TOPMED)
G=0054 (268/5008,1000G)
G=0026 (100/3854,ALSPAC)
G=0025 (92/3708,TWINSUK)
chr14:63725032 (GRCh38.p7) (14q23.2)
AD
GWASdb2
1   publication(s)
See rs on genome
18 Enhancers around
30 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 14NC_000014.9:g.63725032T>G
GRCh37.p13 chr 14NC_000014.8:g.64191750T>G

Gene: SGPP1, sphingosine-1-phosphate phosphatase 1(minus strand)

Molecule type Change Amino acid[Codon] SO Term
SGPP1 transcriptNM_030791.3:c.N/AIntron Variant
SGPP1 transcript variant X1XM_017021678.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.893G=0.107
1000GenomesAmericanSub694T=0.970G=0.030
1000GenomesEast AsianSub1008T=1.000G=0.000
1000GenomesEuropeSub1006T=0.968G=0.032
1000GenomesGlobalStudy-wide5008T=0.946G=0.054
1000GenomesSouth AsianSub978T=0.920G=0.080
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.974G=0.026
The Genome Aggregation DatabaseAfricanSub8672T=0.900G=0.100
The Genome Aggregation DatabaseAmericanSub832T=0.980G=0.020
The Genome Aggregation DatabaseEast AsianSub1614T=1.000G=0.000
The Genome Aggregation DatabaseEuropeSub18340T=0.975G=0.024
The Genome Aggregation DatabaseGlobalStudy-wide29760T=0.955G=0.044
The Genome Aggregation DatabaseOtherSub302T=0.980G=0.020
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.939G=0.060
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.975G=0.025
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs118457650.000162alcohol dependence20201924

eQTL of rs11845765 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs11845765 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr146418008464180134E067-11616
chr146419084464190894E067-856
chr146419098164191204E067-546
chr146419043064190484E068-1266
chr146419055264190602E068-1148
chr146419084464190894E068-856
chr146415678564156976E071-34774
chr146419173064191834E0710
chr146418220664182460E072-9290
chr146418259064182649E072-9101
chr146417902064179093E074-12657
chr146417917364179253E074-12497
chr146418220664182460E074-9290
chr146418259064182649E074-9101
chr146417217064172864E081-18886
chr146419136564191472E081-278
chr146419151264191648E081-102
chr146419173064191834E0810






Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr146419264164193074E067891
chr146419310464193156E0671354
chr146419322864195663E0671478
chr146419264164193074E068891
chr146419310464193156E0681354
chr146419322864195663E0681478
chr146419264164193074E069891
chr146419310464193156E0691354
chr146419322864195663E0691478
chr146419264164193074E070891
chr146419310464193156E0701354
chr146419322864195663E0701478
chr146419264164193074E071891
chr146419310464193156E0711354
chr146419322864195663E0711478
chr146419264164193074E072891
chr146419310464193156E0721354
chr146419322864195663E0721478
chr146419264164193074E073891
chr146419310464193156E0731354
chr146419322864195663E0731478
chr146419264164193074E074891
chr146419310464193156E0741354
chr146419322864195663E0741478
chr146419264164193074E081891
chr146419310464193156E0811354
chr146419322864195663E0811478
chr146419264164193074E082891
chr146419310464193156E0821354
chr146419322864195663E0821478