rs11874707

Homo sapiens
G>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0443 (12920/29118,TOPMED)
T=0360 (10031/27844,GnomAD)
T=0482 (2413/5008,1000G)
T=0205 (789/3854,ALSPAC)
T=0198 (736/3708,TWINSUK)
chr18:5731841 (GRCh38.p7) (18p11.31)
AD
GWASdb2
1   publication(s)
See rs on genome
19 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 18NC_000018.10:g.5731841G>T
GRCh37.p13 chr 18NC_000018.9:g.5731840G>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.287T=0.713
1000GenomesAmericanSub694G=0.540T=0.460
1000GenomesEast AsianSub1008G=0.411T=0.589
1000GenomesEuropeSub1006G=0.811T=0.189
1000GenomesGlobalStudy-wide5008G=0.518T=0.482
1000GenomesSouth AsianSub978G=0.630T=0.370
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.795T=0.205
The Genome Aggregation DatabaseAfricanSub8068G=0.331T=0.669
The Genome Aggregation DatabaseAmericanSub774G=0.560T=0.440
The Genome Aggregation DatabaseEast AsianSub1568G=0.323T=0.677
The Genome Aggregation DatabaseEuropeSub17136G=0.815T=0.184
The Genome Aggregation DatabaseGlobalStudy-wide27844G=0.639T=0.360
The Genome Aggregation DatabaseOtherSub298G=0.770T=0.230
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.556T=0.443
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.802T=0.198
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs118747077.4E-05alcohol consumption (maxi-drinks)24277619

eQTL of rs11874707 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs11874707 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr1857256035725743E068-6097
chr1857259515726470E068-5370
chr1857721165773026E06940276
chr1857687645769047E07036924
chr1857249725725091E081-6749
chr1857251285725197E081-6643
chr1857253335725461E081-6379
chr1857285195728891E081-2949
chr1857291535729207E081-2633
chr1857390315739093E0817191
chr1857391505739375E0817310
chr1857715195771981E08139679
chr1857721165773026E08140276
chr1857172025717690E082-14150
chr1857249725725091E082-6749
chr1857251285725197E082-6643
chr1857253335725461E082-6379
chr1857715195771981E08239679
chr1857721165773026E08240276