rs11908323

Homo sapiens
A>G
RIN2 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0404 (12073/29876,GnomAD)
G=0428 (12480/29118,TOPMED)
G=0406 (2033/5008,1000G)
G=0368 (1417/3854,ALSPAC)
G=0382 (1417/3708,TWINSUK)
chr20:19826835 (GRCh38.p7) (20p11.23)
ND
GWASdb2
1   publication(s)
See rs on genome
234 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 20NC_000020.11:g.19826835A>G
GRCh37.p13 chr 20NC_000020.10:g.19807479A>G

Gene: RIN2, Ras and Rab interactor 2(plus strand)

Molecule type Change Amino acid[Codon] SO Term
RIN2 transcript variant 1NM_001242581.1:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant 2NM_018993.3:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant X7XM_005260731.2:c.N/AIntron Variant
RIN2 transcript variant X6XM_006723574.3:c.N/AIntron Variant
RIN2 transcript variant X5XM_006723575.3:c.N/AIntron Variant
RIN2 transcript variant X2XM_017027887.1:c.N/AIntron Variant
RIN2 transcript variant X3XM_017027888.1:c.N/AIntron Variant
RIN2 transcript variant X19XM_005260733.2:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant X14XM_006723577.2:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant X1XM_011529255.2:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant X10XM_011529257.1:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant X12XM_011529258.2:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant X17XM_011529259.2:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant X4XM_017027889.1:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant X10XM_017027890.1:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant X15XM_017027891.1:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant X16XM_017027892.1:c.N/AGenic Upstream Transcript Variant
RIN2 transcript variant X18XM_017027893.1:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.500G=0.500
1000GenomesAmericanSub694A=0.640G=0.360
1000GenomesEast AsianSub1008A=0.652G=0.348
1000GenomesEuropeSub1006A=0.594G=0.406
1000GenomesGlobalStudy-wide5008A=0.594G=0.406
1000GenomesSouth AsianSub978A=0.630G=0.370
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.632G=0.368
The Genome Aggregation DatabaseAfricanSub8688A=0.533G=0.467
The Genome Aggregation DatabaseAmericanSub834A=0.690G=0.310
The Genome Aggregation DatabaseEast AsianSub1600A=0.669G=0.331
The Genome Aggregation DatabaseEuropeSub18454A=0.617G=0.382
The Genome Aggregation DatabaseGlobalStudy-wide29876A=0.595G=0.404
The Genome Aggregation DatabaseOtherSub300A=0.470G=0.530
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.571G=0.428
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.618G=0.382
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs119083230.000595nicotine dependence17158188

eQTL of rs11908323 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs11908323 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr201976437819766453E067-41026
chr201976655819767638E067-39841
chr201978758319788945E067-18534
chr201979454619794862E067-12617
chr201979499519795216E067-12263
chr201979531819795362E067-12117
chr201979570219795924E067-11555
chr201981449519814545E0677016
chr201981493119815004E0677452
chr201981506619815197E0677587
chr201981581119815861E0678332
chr201981587119815931E0678392
chr201981634219816839E0678863
chr201981686919816919E0679390
chr201981786819817918E06710389
chr201981795719818116E06710478
chr201981816719818227E06710688
chr201981899119819083E06711512
chr201981914619819424E06711667
chr201981966119819767E06712182
chr201981980319819951E06712324
chr201982094419821291E06713465
chr201982133819821388E06713859
chr201982979419831203E06722315
chr201983126019831311E06723781
chr201983204819832098E06724569
chr201983239219832463E06724913
chr201983250619832708E06725027
chr201983271619832849E06725237
chr201983313419833218E06725655
chr201976437819766453E068-41026
chr201976655819767638E068-39841
chr201977313719773234E068-34245
chr201977325519773305E068-34174
chr201978758319788945E068-18534
chr201979499519795216E068-12263
chr201980855519809519E0681076
chr201981358019813864E0686101
chr201981493119815004E0687452
chr201981506619815197E0687587
chr201981914619819424E06811667
chr201981966119819767E06812182
chr201981980319819951E06812324
chr201982000119820086E06812522
chr201982023019820311E06812751
chr201982052319820576E06813044
chr201982094419821291E06813465
chr201982133819821388E06813859
chr201982262219822672E06815143
chr201982979419831203E06822315
chr201983126019831311E06823781
chr201983204819832098E06824569
chr201983239219832463E06824913
chr201983250619832708E06825027
chr201983271619832849E06825237
chr201976437819766453E069-41026
chr201976655819767638E069-39841
chr201977313719773234E069-34245
chr201977325519773305E069-34174
chr201979499519795216E069-12263
chr201979606419796711E069-10768
chr201979673919796847E069-10632
chr201981493119815004E0697452
chr201981506619815197E0697587
chr201981581119815861E0698332
chr201981587119815931E0698392
chr201981634219816839E0698863
chr201981686919816919E0699390
chr201981914619819424E06911667
chr201981966119819767E06912182
chr201981980319819951E06912324
chr201982000119820086E06912522
chr201982023019820311E06912751
chr201982052319820576E06913044
chr201982094419821291E06913465
chr201982133819821388E06913859
chr201982262219822672E06915143
chr201982979419831203E06922315
chr201983126019831311E06923781
chr201983204819832098E06924569
chr201983239219832463E06924913
chr201983250619832708E06925027
chr201983271619832849E06925237
chr201983313419833218E06925655
chr201982979419831203E07022315
chr201975807019758256E071-49223
chr201975828319758438E071-49041
chr201975853419758574E071-48905
chr201976068119761313E071-46166
chr201976136019761524E071-45955
chr201976437819766453E071-41026
chr201976655819767638E071-39841
chr201977313719773234E071-34245
chr201977325519773305E071-34174
chr201978758319788945E071-18534
chr201979365919793699E071-13780
chr201979391319794042E071-13437
chr201979406019794140E071-13339
chr201979454619794862E071-12617
chr201979499519795216E071-12263
chr201979531819795362E071-12117
chr201979570219795924E071-11555
chr201980246319802527E071-4952
chr201980255219802633E071-4846
chr201980264919802699E071-4780
chr201980298419803082E071-4397
chr201980855519809519E0711076
chr201980954219809627E0712063
chr201981407419814468E0716595
chr201981449519814545E0717016
chr201981493119815004E0717452
chr201981506619815197E0717587
chr201981581119815861E0718332
chr201981587119815931E0718392
chr201981634219816839E0718863
chr201981786819817918E07110389
chr201981795719818116E07110478
chr201981914619819424E07111667
chr201981966119819767E07112182
chr201981980319819951E07112324
chr201982094419821291E07113465
chr201982133819821388E07113859
chr201982262219822672E07115143
chr201982979419831203E07122315
chr201983204819832098E07124569
chr201983239219832463E07124913
chr201983250619832708E07125027
chr201983271619832849E07125237
chr201983313419833218E07125655
chr201983866019838710E07131181
chr201983883319838916E07131354
chr201984840219849428E07140923
chr201984950819849558E07142029
chr201975873219758882E072-48597
chr201975916219759322E072-48157
chr201976068119761313E072-46166
chr201976136019761524E072-45955
chr201976168719761798E072-45681
chr201976437819766453E072-41026
chr201976655819767638E072-39841
chr201977313719773234E072-34245
chr201977325519773305E072-34174
chr201978758319788945E072-18534
chr201979281119792984E072-14495
chr201979343919793543E072-13936
chr201979365919793699E072-13780
chr201979391319794042E072-13437
chr201979406019794140E072-13339
chr201979454619794862E072-12617
chr201979499519795216E072-12263
chr201979531819795362E072-12117
chr201980246319802527E072-4952
chr201980855519809519E0721076
chr201980954219809627E0722063
chr201981493119815004E0727452
chr201981506619815197E0727587
chr201981581119815861E0728332
chr201981587119815931E0728392
chr201981686919816919E0729390
chr201981899119819083E07211512
chr201981914619819424E07211667
chr201981966119819767E07212182
chr201981980319819951E07212324
chr201982000119820086E07212522
chr201982023019820311E07212751
chr201982094419821291E07213465
chr201982262219822672E07215143
chr201982979419831203E07222315
chr201983126019831311E07223781
chr201983204819832098E07224569
chr201983239219832463E07224913
chr201983250619832708E07225027
chr201983271619832849E07225237
chr201983313419833218E07225655
chr201976437819766453E073-41026
chr201976655819767638E073-39841
chr201978758319788945E073-18534
chr201979391319794042E073-13437
chr201979406019794140E073-13339
chr201979499519795216E073-12263
chr201979531819795362E073-12117
chr201981449519814545E0737016
chr201981493119815004E0737452
chr201981506619815197E0737587
chr201982979419831203E07322315
chr201983126019831311E07323781
chr201983204819832098E07324569
chr201983239219832463E07324913
chr201983250619832708E07325027
chr201983271619832849E07325237
chr201976068119761313E074-46166
chr201976136019761524E074-45955
chr201976437819766453E074-41026
chr201976655819767638E074-39841
chr201978758319788945E074-18534
chr201979343919793543E074-13936
chr201979365919793699E074-13780
chr201979391319794042E074-13437
chr201979406019794140E074-13339
chr201979454619794862E074-12617
chr201979499519795216E074-12263
chr201979531819795362E074-12117
chr201979570219795924E074-11555
chr201979606419796711E074-10768
chr201979673919796847E074-10632
chr201979686719797077E074-10402
chr201981493119815004E0747452
chr201981506619815197E0747587
chr201981581119815861E0748332
chr201981587119815931E0748392
chr201981634219816839E0748863
chr201981966119819767E07412182
chr201981980319819951E07412324
chr201982000119820086E07412522
chr201982133819821388E07413859
chr201982979419831203E07422315
chr201983126019831311E07423781
chr201983204819832098E07424569
chr201983239219832463E07424913
chr201983250619832708E07425027
chr201983271619832849E07425237
chr201976437819766453E081-41026
chr201978916919789260E081-18219
chr201978951819789568E081-17911
chr201978967019789745E081-17734
chr201978997719790077E081-17402
chr201979011019790539E081-16940
chr201980109919801630E081-5849
chr201976437819766453E082-41026
chr201976655819767638E082-39841
chr201978758319788945E082-18534
chr201978916919789260E082-18219
chr201981634219816839E0828863
chr201981686919816919E0829390