SNP Detail Info-rs11918452

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

LOC105377167 : Intron Variant

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G==0132 (3964/29928,GnomAD)
G==0109 (3197/29118,TOPMED)
G==0139 (695/5008,1000G)
G==0179 (690/3854,ALSPAC)
G==0165 (612/3708,TWINSUK)

Position: chr3:74833134 (GRCh38.p7) (3p12.3)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 24 Enhancers around

Promoter: 0 Promoter around

Sequence Name	Change(s)
GRCh38.p7 chr 3	NC_000003.12:g.74833134G>A
GRCh37.p13 chr 3	NC_000003.11:g.74882285G>A

Molecule type	Change	Amino acid[Codon]	SO Term
LOC105377167 transcript variant X4	XR_001740758.1:n.	N/A	Intron Variant
LOC105377167 transcript variant X1	XR_940970.2:n.	N/A	Intron Variant
LOC105377167 transcript variant X3	XR_940972.2:n.	N/A	Intron Variant
LOC105377167 transcript variant X2	XR_940971.1:n.	N/A	Genic Upstream Transcript Variant

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.013	A=0.987
1000Genomes	American	Sub	694	G=0.140	A=0.860
1000Genomes	East Asian	Sub	1008	G=0.272	A=0.728
1000Genomes	Europe	Sub	1006	G=0.164	A=0.836
1000Genomes	Global	Study-wide	5008	G=0.139	A=0.861
1000Genomes	South Asian	Sub	978	G=0.150	A=0.850
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.179	A=0.821
The Genome Aggregation Database	African	Sub	8728	G=0.034	A=0.966
The Genome Aggregation Database	American	Sub	836	G=0.140	A=0.860
The Genome Aggregation Database	East Asian	Sub	1604	G=0.269	A=0.731
The Genome Aggregation Database	Europe	Sub	18458	G=0.164	A=0.835
The Genome Aggregation Database	Global	Study-wide	29928	G=0.132	A=0.867
The Genome Aggregation Database	Other	Sub	302	G=0.240	A=0.760
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.109	A=0.890
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.165	A=0.835

PMID	Title	Author	Journal
20201924	Genome-wide association study of alcohol dependence implicates a region on chromosome 11.	Edenberg HJ	Alcohol Clin Exp Res

SNP ID	p-value	Traits	Study
rs11918452	0.000968	alcohol dependence	20201924

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr3	74836208	74836566	E070	-45719
chr3	74836763	74836844	E070	-45441
chr3	74897606	74897665	E070	15321
chr3	74897713	74897763	E070	15428
chr3	74836208	74836566	E081	-45719
chr3	74836763	74836844	E081	-45441
chr3	74861909	74862266	E081	-20019
chr3	74864539	74864589	E081	-17696
chr3	74906732	74906857	E081	24447
chr3	74906988	74907142	E081	24703
chr3	74907307	74907560	E081	25022
chr3	74907660	74907824	E081	25375
chr3	74908192	74908343	E081	25907
chr3	74911333	74911489	E081	29048
chr3	74911790	74911914	E081	29505
chr3	74913539	74913589	E081	31254
chr3	74836208	74836566	E082	-45719
chr3	74836763	74836844	E082	-45441
chr3	74908192	74908343	E082	25907
chr3	74910550	74910610	E082	28265
chr3	74911142	74911192	E082	28857
chr3	74911333	74911489	E082	29048
chr3	74911790	74911914	E082	29505
chr3	74915388	74916366	E082	33103

rs11918452