rs11918665

Organism: Homo sapiens

Alleles: A>G

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A==0093 (2805/29996,GnomAD)
A==0076 (2227/29118,TOPMED)
A==0076 (380/5008,1000G)
A==0133 (511/3854,ALSPAC)
A==0140 (519/3708,TWINSUK)

Position: chr3:186495995 (GRCh38.p7) (3q27.3)

Phenotype: AD | ND

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 67 Enhancers around

Promoter: 0 Promoter around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 3	NC_000003.12:g.186495995A>G
GRCh37.p13 chr 3	NC_000003.11:g.186213784A>G

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	A=0.016	G=0.984
1000Genomes	American	Sub	694	A=0.110	G=0.890
1000Genomes	East Asian	Sub	1008	A=0.057	G=0.943
1000Genomes	Europe	Sub	1006	A=0.117	G=0.883
1000Genomes	Global	Study-wide	5008	A=0.076	G=0.924
1000Genomes	South Asian	Sub	978	A=0.110	G=0.890
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.133	G=0.867
The Genome Aggregation Database	African	Sub	8730	A=0.026	G=0.974
The Genome Aggregation Database	American	Sub	838	A=0.090	G=0.910
The Genome Aggregation Database	East Asian	Sub	1622	A=0.048	G=0.952
The Genome Aggregation Database	Europe	Sub	18504	A=0.129	G=0.870
The Genome Aggregation Database	Global	Study-wide	29996	A=0.093	G=0.906
The Genome Aggregation Database	Other	Sub	302	A=0.130	G=0.870
Trans-Omics for Precision Medicine	Global	Study-wide	29118	A=0.076	G=0.923
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.140	G=0.860

PMID	Title	Author	Journal
23942779	A genome-wide association study of behavioral disinhibition.	McGue M	Behav Genet

P-Value

SNP ID	p-value	Traits	Study
rs11918665	0.00042	nicotine use	23942779
rs11918665	0.00055	alcohol consumption	23942779

eQTL of rs11918665 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs11918665 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr3	186193866	186194070	E067	-19714
chr3	186194114	186194281	E067	-19503
chr3	186194312	186194384	E067	-19400
chr3	186194640	186194717	E067	-19067
chr3	186231275	186231562	E067	17491
chr3	186250353	186250481	E067	36569
chr3	186258038	186259015	E067	44254
chr3	186193866	186194070	E068	-19714
chr3	186194114	186194281	E068	-19503
chr3	186194312	186194384	E068	-19400
chr3	186194640	186194717	E068	-19067
chr3	186231275	186231562	E068	17491
chr3	186258038	186259015	E068	44254
chr3	186194312	186194384	E069	-19400
chr3	186194640	186194717	E069	-19067
chr3	186220396	186220585	E069	6612
chr3	186220627	186220766	E069	6843
chr3	186255125	186255389	E069	41341
chr3	186258038	186259015	E069	44254
chr3	186193866	186194070	E070	-19714
chr3	186194114	186194281	E070	-19503
chr3	186194312	186194384	E070	-19400
chr3	186187604	186187648	E071	-26136
chr3	186187941	186188016	E071	-25768
chr3	186188099	186188139	E071	-25645
chr3	186194640	186194717	E071	-19067
chr3	186220627	186220766	E071	6843
chr3	186221304	186221359	E071	7520
chr3	186231757	186231807	E071	17973
chr3	186258038	186259015	E071	44254
chr3	186193866	186194070	E072	-19714
chr3	186194114	186194281	E072	-19503
chr3	186194312	186194384	E072	-19400
chr3	186194640	186194717	E072	-19067
chr3	186231275	186231562	E072	17491
chr3	186231757	186231807	E072	17973
chr3	186258038	186259015	E072	44254
chr3	186193866	186194070	E073	-19714
chr3	186194114	186194281	E073	-19503
chr3	186194312	186194384	E073	-19400
chr3	186194640	186194717	E073	-19067
chr3	186246627	186247446	E073	32843
chr3	186247510	186247618	E073	33726
chr3	186193866	186194070	E074	-19714
chr3	186194114	186194281	E074	-19503
chr3	186194312	186194384	E074	-19400
chr3	186194640	186194717	E074	-19067
chr3	186231275	186231562	E074	17491
chr3	186258038	186259015	E074	44254
chr3	186189430	186190293	E081	-23491
chr3	186190364	186190626	E081	-23158
chr3	186191094	186191225	E081	-22559
chr3	186193866	186194070	E081	-19714
chr3	186194114	186194281	E081	-19503
chr3	186194312	186194384	E081	-19400
chr3	186194640	186194717	E081	-19067
chr3	186211748	186211802	E081	-1982
chr3	186212503	186212566	E081	-1218
chr3	186212641	186212753	E081	-1031
chr3	186189430	186190293	E082	-23491
chr3	186190364	186190626	E082	-23158
chr3	186193866	186194070	E082	-19714
chr3	186194114	186194281	E082	-19503
chr3	186210170	186210232	E082	-3552
chr3	186210334	186210387	E082	-3397
chr3	186210484	186210614	E082	-3170
chr3	186211748	186211802	E082	-1982