rs11922615

Homo sapiens
A>G
SETD5 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0081 (2450/29964,GnomAD)
G=0122 (3575/29118,TOPMED)
G=0096 (480/5008,1000G)
G=0001 (3/3854,ALSPAC)
G=0001 (2/3708,TWINSUK)
chr3:9416623 (GRCh38.p7) (3p25.3)
AD
GWASdb2
1   publication(s)
See rs on genome
140 Enhancers around
10 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.9416623A>G
GRCh37.p13 chr 3NC_000003.11:g.9458307A>G
SETD5 RefSeqGeneNG_034132.1:g.23924A>G

Gene: SETD5, SET domain containing 5(plus strand)

Molecule type Change Amino acid[Codon] SO Term
SETD5 transcript variant 1NM_001080517.2:c.N/AIntron Variant
SETD5 transcript variant 2NM_001292043.1:c.N/AIntron Variant
SETD5 transcript variant X13XM_005265301.1:c.N/AIntron Variant
SETD5 transcript variant X17XM_005265303.1:c.N/AIntron Variant
SETD5 transcript variant X2XM_011533920.1:c.N/AIntron Variant
SETD5 transcript variant X3XM_011533921.1:c.N/AIntron Variant
SETD5 transcript variant X4XM_011533922.1:c.N/AIntron Variant
SETD5 transcript variant X8XM_011533927.1:c.N/AIntron Variant
SETD5 transcript variant X10XM_011533928.1:c.N/AIntron Variant
SETD5 transcript variant X15XM_011533930.1:c.N/AIntron Variant
SETD5 transcript variant X23XM_011533932.1:c.N/AIntron Variant
SETD5 transcript variant X1XM_017006767.1:c.N/AIntron Variant
SETD5 transcript variant X6XM_017006769.1:c.N/AIntron Variant
SETD5 transcript variant X7XM_017006770.1:c.N/AIntron Variant
SETD5 transcript variant X9XM_017006771.1:c.N/AIntron Variant
SETD5 transcript variant X11XM_017006772.1:c.N/AIntron Variant
SETD5 transcript variant X12XM_017006773.1:c.N/AIntron Variant
SETD5 transcript variant X14XM_017006774.1:c.N/AIntron Variant
SETD5 transcript variant X16XM_017006775.1:c.N/AIntron Variant
SETD5 transcript variant X19XM_017006776.1:c.N/AIntron Variant
SETD5 transcript variant X20XM_017006777.1:c.N/AIntron Variant
SETD5 transcript variant X21XM_017006778.1:c.N/AIntron Variant
SETD5 transcript variant X22XM_017006779.1:c.N/AIntron Variant
SETD5 transcript variant X24XM_017006780.1:c.N/AIntron Variant
SETD5 transcript variant X25XM_017006781.1:c.N/AIntron Variant
SETD5 transcript variant X26XM_017006782.1:c.N/AIntron Variant
SETD5 transcript variant X27XM_017006783.1:c.N/AIntron Variant
SETD5 transcript variant X28XM_017006784.1:c.N/AIntron Variant
SETD5 transcript variant X30XM_017006785.1:c.N/AIntron Variant
SETD5 transcript variant X31XM_017006786.1:c.N/AIntron Variant
SETD5 transcript variant X25XM_011533933.1:c.N/AGenic Upstream Transcript Variant
SETD5 transcript variant X5XM_017006768.1:c.N/AGenic Upstream Transcript Variant
SETD5 transcript variant X29XR_001740195.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.655G=0.345
1000GenomesAmericanSub694A=0.970G=0.030
1000GenomesEast AsianSub1008A=0.999G=0.001
1000GenomesEuropeSub1006A=0.999G=0.001
1000GenomesGlobalStudy-wide5008A=0.904G=0.096
1000GenomesSouth AsianSub978A=1.000G=0.000
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.999G=0.001
The Genome Aggregation DatabaseAfricanSub8700A=0.722G=0.278
The Genome Aggregation DatabaseAmericanSub838A=0.980G=0.020
The Genome Aggregation DatabaseEast AsianSub1622A=1.000G=0.000
The Genome Aggregation DatabaseEuropeSub18502A=0.999G=0.000
The Genome Aggregation DatabaseGlobalStudy-wide29964A=0.918G=0.081
The Genome Aggregation DatabaseOtherSub302A=1.000G=0.000
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.877G=0.122
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.999G=0.001
PMID Title Author Journal
22096494A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association study.Zuo LPLoS One

P-Value

SNP ID p-value Traits Study
rs119226152.6E-08alcohol dependence22096494

eQTL of rs11922615 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs11922615 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr394364249436486E067-21821
chr394364879436537E067-21770
chr394365449436599E067-21708
chr394366519436708E067-21599
chr394368989436998E067-21309
chr394432499443300E067-15007
chr394438939443996E067-14311
chr394449779445050E067-13257
chr394452529445334E067-12973
chr394453419445395E067-12912
chr394463049446362E067-11945
chr394463679446417E067-11890
chr394464489446643E067-11664
chr394475059447705E067-10602
chr394516949451915E067-6392
chr394519879452102E067-6205
chr394641049464156E0675797
chr394642989465111E0675991
chr394812099481319E06722902
chr394904169490594E06732109
chr394345359434642E068-23665
chr394432499443300E068-15007
chr394438939443996E068-14311
chr394452529445334E068-12973
chr394453419445395E068-12912
chr394463049446362E068-11945
chr394463679446417E068-11890
chr394464489446643E068-11664
chr394475059447705E068-10602
chr394516949451915E068-6392
chr394519879452102E068-6205
chr394521149452510E068-5797
chr394541229454174E068-4133
chr394641049464156E0685797
chr394642989465111E0685991
chr394812099481319E06822902
chr394904169490594E06832109
chr394368989436998E069-21309
chr394432499443300E069-15007
chr394438939443996E069-14311
chr394449779445050E069-13257
chr394452529445334E069-12973
chr394453419445395E069-12912
chr394463049446362E069-11945
chr394463679446417E069-11890
chr394464489446643E069-11664
chr394475059447705E069-10602
chr394546249454700E069-3607
chr394626019462863E0694294
chr394631759463237E0694868
chr394641049464156E0695797
chr394642989465111E0695991
chr394904169490594E06932109
chr394345359434642E070-23665
chr394366519436708E070-21599
chr394368989436998E070-21309
chr394432499443300E070-15007
chr394452529445334E070-12973
chr394453419445395E070-12912
chr394475059447705E070-10602
chr394641049464156E0705797
chr394364249436486E071-21821
chr394364879436537E071-21770
chr394365449436599E071-21708
chr394366519436708E071-21599
chr394368989436998E071-21309
chr394432499443300E071-15007
chr394452529445334E071-12973
chr394453419445395E071-12912
chr394463049446362E071-11945
chr394463679446417E071-11890
chr394464489446643E071-11664
chr394475059447705E071-10602
chr394584119458482E071104
chr394626019462863E0714294
chr394641049464156E0715797
chr394642989465111E0715991
chr394812099481319E07122902
chr394904169490594E07132109
chr394432499443300E072-15007
chr394438939443996E072-14311
chr394449779445050E072-13257
chr394452529445334E072-12973
chr394453419445395E072-12912
chr394463049446362E072-11945
chr394463679446417E072-11890
chr394464489446643E072-11664
chr394475059447705E072-10602
chr394516949451915E072-6392
chr394519879452102E072-6205
chr394521149452510E072-5797
chr394577029458329E0720
chr394584119458482E072104
chr394812099481319E07222902
chr394904169490594E07232109
chr394364249436486E073-21821
chr394364879436537E073-21770
chr394365449436599E073-21708
chr394366519436708E073-21599
chr394368989436998E073-21309
chr394432499443300E073-15007
chr394438939443996E073-14311
chr394449779445050E073-13257
chr394452529445334E073-12973
chr394453419445395E073-12912
chr394463049446362E073-11945
chr394463679446417E073-11890
chr394464489446643E073-11664
chr394475059447705E073-10602
chr394516949451915E073-6392
chr394519879452102E073-6205
chr394904169490594E07332109
chr394366519436708E074-21599
chr394368989436998E074-21309
chr394432499443300E074-15007
chr394449779445050E074-13257
chr394452529445334E074-12973
chr394453419445395E074-12912
chr394463049446362E074-11945
chr394463679446417E074-11890
chr394464489446643E074-11664
chr394475059447705E074-10602
chr394527859452867E074-5440
chr394528989452975E074-5332
chr394541229454174E074-4133
chr394626019462863E0744294
chr394631759463237E0744868
chr394641049464156E0745797
chr394642989465111E0745991
chr394668139466918E0748506
chr394812099481319E07422902
chr394904169490594E07432109
chr394368989436998E081-21309
chr394449779445050E081-13257
chr394452529445334E081-12973
chr394453419445395E081-12912
chr394642989465111E0815991
chr394463679446417E082-11890
chr394464489446643E082-11664
chr394642989465111E0825991










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr394371269441870E067-16437
chr394371269441870E068-16437
chr394371269441870E069-16437
chr394371269441870E070-16437
chr394371269441870E071-16437
chr394371269441870E072-16437
chr394371269441870E073-16437
chr394371269441870E074-16437
chr394371269441870E081-16437
chr394371269441870E082-16437