rs11924509

Homo sapiens
G>A
LOC105374086 : Non Coding Transcript Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0230 (6901/29932,GnomAD)
A=0250 (7289/29118,TOPMED)
A=0248 (1240/5008,1000G)
A=0157 (604/3854,ALSPAC)
A=0167 (620/3708,TWINSUK)
chr3:126215378 (GRCh38.p7) (3q21.3)
AD
GWASdb2
1   publication(s)
See rs on genome
51 Enhancers around
36 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.126215378G>A
GRCh37.p13 chr 3NC_000003.11:g.125934221G>A

Gene: LOC105374086, uncharacterized LOC105374086(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105374086 transcript variant X1XR_924443.2:n.214...XR_924443.2:n.2142G>AG>ANon Coding Transcript Variant
LOC105374086 transcript variant X2XR_924445.2:n.214...XR_924445.2:n.2143G>AG>ANon Coding Transcript Variant
LOC105374086 transcript variant X3XR_924446.2:n.214...XR_924446.2:n.2142G>AG>ANon Coding Transcript Variant
LOC105374086 transcript variant X4XR_001740880.1:n....XR_001740880.1:n.2143G>AG>ANon Coding Transcript Variant
LOC105374086 transcript variant X5XR_001740881.1:n....XR_001740881.1:n.2142G>AG>ANon Coding Transcript Variant
LOC105374086 transcript variant X6XR_924444.2:n.164...XR_924444.2:n.1646G>AG>ANon Coding Transcript Variant
LOC105374086 transcript variant X7XR_924447.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.552A=0.448
1000GenomesAmericanSub694G=0.730A=0.270
1000GenomesEast AsianSub1008G=0.821A=0.179
1000GenomesEuropeSub1006G=0.814A=0.186
1000GenomesGlobalStudy-wide5008G=0.752A=0.248
1000GenomesSouth AsianSub978G=0.910A=0.090
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.843A=0.157
The Genome Aggregation DatabaseAfricanSub8696G=0.630A=0.370
The Genome Aggregation DatabaseAmericanSub838G=0.730A=0.270
The Genome Aggregation DatabaseEast AsianSub1618G=0.794A=0.206
The Genome Aggregation DatabaseEuropeSub18478G=0.832A=0.167
The Genome Aggregation DatabaseGlobalStudy-wide29932G=0.769A=0.230
The Genome Aggregation DatabaseOtherSub302G=0.870A=0.130
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.749A=0.250
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.833A=0.167
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs119245090.000156alcohol consumption (maxi-drinks)24277619

eQTL of rs11924509 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs11924509 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr3125933092125933152E067-1069
chr3125983412125983494E06749191
chr3125925524125925609E068-8612
chr3125927123125927349E068-6872
chr3125927518125927758E068-6463
chr3125945310125945585E06811089
chr3125978385125978858E06844164
chr3125978999125979053E06844778
chr3125979179125979229E06844958
chr3125979339125979394E06845118
chr3125979435125979551E06845214
chr3125979552125979648E06845331
chr3125979768125980346E06845547
chr3125921236125921433E069-12788
chr3125927123125927349E070-6872
chr3125927518125927758E070-6463
chr3125927518125927758E071-6463
chr3125933092125933152E071-1069
chr3125978385125978858E07144164
chr3125979552125979648E07145331
chr3125979768125980346E07145547
chr3125921236125921433E072-12788
chr3125921236125921433E073-12788
chr3125927123125927349E073-6872
chr3125927518125927758E073-6463
chr3125928006125928087E073-6134
chr3125933092125933152E073-1069
chr3125978385125978858E07344164
chr3125978999125979053E07344778
chr3125979179125979229E07344958
chr3125979339125979394E07345118
chr3125979435125979551E07345214
chr3125979552125979648E07345331
chr3125979768125980346E07345547
chr3125903304125903409E074-30812
chr3125921236125921433E074-12788
chr3125927123125927349E074-6872
chr3125927518125927758E074-6463
chr3125928006125928087E074-6134
chr3125933092125933152E074-1069
chr3125921236125921433E081-12788
chr3125922225125922431E081-11790
chr3125924487125924587E081-9634
chr3125925081125925414E081-8807
chr3125933092125933152E081-1069
chr3125979179125979229E08144958
chr3125979339125979394E08145118
chr3125979435125979551E08145214
chr3125979552125979648E08145331
chr3125979768125980346E08145547
chr3125921236125921433E082-12788










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr3125898194125898244E067-35977
chr3125898362125899209E067-35012
chr3125899244125900199E067-34022
chr3125931437125932766E067-1455
chr3125897759125898050E068-36171
chr3125898194125898244E068-35977
chr3125898362125899209E068-35012
chr3125899244125900199E068-34022
chr3125931437125932766E068-1455
chr3125897759125898050E069-36171
chr3125898194125898244E069-35977
chr3125898362125899209E069-35012
chr3125899244125900199E069-34022
chr3125931437125932766E069-1455
chr3125931437125932766E070-1455
chr3125897759125898050E071-36171
chr3125898194125898244E071-35977
chr3125898362125899209E071-35012
chr3125899244125900199E071-34022
chr3125931437125932766E071-1455
chr3125898194125898244E072-35977
chr3125898362125899209E072-35012
chr3125899244125900199E072-34022
chr3125931437125932766E072-1455
chr3125897759125898050E073-36171
chr3125898194125898244E073-35977
chr3125898362125899209E073-35012
chr3125899244125900199E073-34022
chr3125931437125932766E073-1455
chr3125897759125898050E074-36171
chr3125898194125898244E074-35977
chr3125898362125899209E074-35012
chr3125899244125900199E074-34022
chr3125931437125932766E074-1455
chr3125899244125900199E082-34022
chr3125931437125932766E082-1455