rs1199335

Homo sapiens
A>G
MRAS : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A==0155 (4639/29932,GnomAD)
A==0142 (4155/29118,TOPMED)
A==0119 (597/5008,1000G)
A==0181 (697/3854,ALSPAC)
A==0181 (670/3708,TWINSUK)
chr3:138370982 (GRCh38.p7) (3q22.3)
AD
GWASdb2
1   publication(s)
See rs on genome
336 Enhancers around
38 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.138370982A>G
GRCh37.p13 chr 3NC_000003.11:g.138089824A>G

Gene: MRAS, muscle RAS oncogene homolog(plus strand)

Molecule type Change Amino acid[Codon] SO Term
MRAS transcript variant 2NM_001085049.2:c.N/AIntron Variant
MRAS transcript variant 3NM_001252090.1:c.N/AIntron Variant
MRAS transcript variant 4NM_001252091.1:c.N/AIntron Variant
MRAS transcript variant 5NM_001252092.1:c.N/AIntron Variant
MRAS transcript variant 6NM_001252093.1:c.N/AIntron Variant
MRAS transcript variant 1NM_012219.4:c.N/AIntron Variant
MRAS transcript variant X1XM_005247228.1:c.N/AIntron Variant
MRAS transcript variant X4XM_005247229.2:c.N/AIntron Variant
MRAS transcript variant X2XM_017005887.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.074G=0.926
1000GenomesAmericanSub694A=0.130G=0.870
1000GenomesEast AsianSub1008A=0.035G=0.965
1000GenomesEuropeSub1006A=0.181G=0.819
1000GenomesGlobalStudy-wide5008A=0.119G=0.881
1000GenomesSouth AsianSub978A=0.190G=0.810
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.181G=0.819
The Genome Aggregation DatabaseAfricanSub8712A=0.099G=0.901
The Genome Aggregation DatabaseAmericanSub836A=0.100G=0.900
The Genome Aggregation DatabaseEast AsianSub1622A=0.021G=0.979
The Genome Aggregation DatabaseEuropeSub18460A=0.194G=0.805
The Genome Aggregation DatabaseGlobalStudy-wide29932A=0.155G=0.845
The Genome Aggregation DatabaseOtherSub302A=0.240G=0.760
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.142G=0.857
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.181G=0.819
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs11993350.000833alcohol dependence21314694

eQTL of rs1199335 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1199335 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr3138046682138047112E067-42712
chr3138075595138076105E067-13719
chr3138078007138078057E067-11767
chr3138078178138078228E067-11596
chr3138078510138078657E067-11167
chr3138078941138079153E067-10671
chr3138079312138079906E067-9918
chr3138081555138081786E067-8038
chr3138082802138082875E067-6949
chr3138086544138086633E067-3191
chr3138086749138087130E067-2694
chr3138087889138088029E067-1795
chr3138088311138088391E067-1433
chr3138088616138088720E067-1104
chr3138088783138088837E067-987
chr3138100510138101291E06710686
chr3138101527138101599E06711703
chr3138101617138101667E06711793
chr3138101679138101789E06711855
chr3138102184138102234E06712360
chr3138102491138102541E06712667
chr3138102606138103081E06712782
chr3138103418138103509E06713594
chr3138103677138103901E06713853
chr3138108544138109616E06718720
chr3138114470138114543E06724646
chr3138114708138114905E06724884
chr3138115172138115263E06725348
chr3138126189138126390E06736365
chr3138126449138126519E06736625
chr3138126711138126796E06736887
chr3138126914138127002E06737090
chr3138127634138128348E06737810
chr3138046682138047112E068-42712
chr3138069892138070318E068-19506
chr3138070405138070485E068-19339
chr3138070796138070996E068-18828
chr3138071156138071265E068-18559
chr3138075595138076105E068-13719
chr3138078007138078057E068-11767
chr3138078178138078228E068-11596
chr3138078510138078657E068-11167
chr3138078941138079153E068-10671
chr3138079312138079906E068-9918
chr3138080146138080207E068-9617
chr3138080433138080865E068-8959
chr3138081555138081786E068-8038
chr3138082802138082875E068-6949
chr3138083689138083874E068-5950
chr3138084224138084274E068-5550
chr3138084569138084720E068-5104
chr3138084855138084992E068-4832
chr3138085036138085173E068-4651
chr3138085353138085624E068-4200
chr3138086544138086633E068-3191
chr3138086749138087130E068-2694
chr3138087889138088029E068-1795
chr3138088311138088391E068-1433
chr3138088616138088720E068-1104
chr3138088783138088837E068-987
chr3138089907138089957E06883
chr3138090024138090171E068200
chr3138090472138090782E068648
chr3138090888138090993E0681064
chr3138091063138091113E0681239
chr3138091173138091357E0681349
chr3138096721138097183E0686897
chr3138098686138098736E0688862
chr3138100510138101291E06810686
chr3138101527138101599E06811703
chr3138101617138101667E06811793
chr3138101679138101789E06811855
chr3138102184138102234E06812360
chr3138102491138102541E06812667
chr3138102606138103081E06812782
chr3138103418138103509E06813594
chr3138103677138103901E06813853
chr3138108184138108338E06818360
chr3138108388138108451E06818564
chr3138108544138109616E06818720
chr3138114470138114543E06824646
chr3138114708138114905E06824884
chr3138115172138115263E06825348
chr3138115339138115437E06825515
chr3138115631138115760E06825807
chr3138115792138115893E06825968
chr3138117238138117292E06827414
chr3138117947138118339E06828123
chr3138118550138119096E06828726
chr3138119350138119824E06829526
chr3138127634138128348E06837810
chr3138069519138069628E069-20196
chr3138069892138070318E069-19506
chr3138070405138070485E069-19339
chr3138070796138070996E069-18828
chr3138075595138076105E069-13719
chr3138078007138078057E069-11767
chr3138078178138078228E069-11596
chr3138078510138078657E069-11167
chr3138078941138079153E069-10671
chr3138079312138079906E069-9918
chr3138080146138080207E069-9617
chr3138080433138080865E069-8959
chr3138081555138081786E069-8038
chr3138082802138082875E069-6949
chr3138083689138083874E069-5950
chr3138084224138084274E069-5550
chr3138084569138084720E069-5104
chr3138084855138084992E069-4832
chr3138085036138085173E069-4651
chr3138085353138085624E069-4200
chr3138086544138086633E069-3191
chr3138086749138087130E069-2694
chr3138087889138088029E069-1795
chr3138088311138088391E069-1433
chr3138088616138088720E069-1104
chr3138088783138088837E069-987
chr3138090024138090171E069200
chr3138091173138091357E0691349
chr3138092100138092243E0692276
chr3138100510138101291E06910686
chr3138101527138101599E06911703
chr3138101617138101667E06911793
chr3138101679138101789E06911855
chr3138102184138102234E06912360
chr3138102491138102541E06912667
chr3138102606138103081E06912782
chr3138103418138103509E06913594
chr3138103677138103901E06913853
chr3138108184138108338E06918360
chr3138108388138108451E06918564
chr3138108544138109616E06918720
chr3138115172138115263E06925348
chr3138115339138115437E06925515
chr3138115631138115760E06925807
chr3138115792138115893E06925968
chr3138116941138117017E06927117
chr3138117238138117292E06927414
chr3138117700138117801E06927876
chr3138117947138118339E06928123
chr3138127634138128348E06937810
chr3138069519138069628E070-20196
chr3138069892138070318E070-19506
chr3138070405138070485E070-19339
chr3138070796138070996E070-18828
chr3138127634138128348E07037810
chr3138128441138128546E07038617
chr3138128596138128678E07038772
chr3138069519138069628E071-20196
chr3138069892138070318E071-19506
chr3138070405138070485E071-19339
chr3138070796138070996E071-18828
chr3138075595138076105E071-13719
chr3138078007138078057E071-11767
chr3138078178138078228E071-11596
chr3138078510138078657E071-11167
chr3138078941138079153E071-10671
chr3138079312138079906E071-9918
chr3138080146138080207E071-9617
chr3138080433138080865E071-8959
chr3138081555138081786E071-8038
chr3138082802138082875E071-6949
chr3138083689138083874E071-5950
chr3138084224138084274E071-5550
chr3138084569138084720E071-5104
chr3138084855138084992E071-4832
chr3138085036138085173E071-4651
chr3138085353138085624E071-4200
chr3138086544138086633E071-3191
chr3138086749138087130E071-2694
chr3138087889138088029E071-1795
chr3138088311138088391E071-1433
chr3138088616138088720E071-1104
chr3138088783138088837E071-987
chr3138090472138090782E071648
chr3138090888138090993E0711064
chr3138098686138098736E0718862
chr3138100510138101291E07110686
chr3138101527138101599E07111703
chr3138101617138101667E07111793
chr3138101679138101789E07111855
chr3138102184138102234E07112360
chr3138102491138102541E07112667
chr3138102606138103081E07112782
chr3138108184138108338E07118360
chr3138108388138108451E07118564
chr3138108544138109616E07118720
chr3138114470138114543E07124646
chr3138114708138114905E07124884
chr3138115172138115263E07125348
chr3138115339138115437E07125515
chr3138117238138117292E07127414
chr3138117700138117801E07127876
chr3138127634138128348E07137810
chr3138051419138051760E072-38064
chr3138051766138051875E072-37949
chr3138069892138070318E072-19506
chr3138070405138070485E072-19339
chr3138070796138070996E072-18828
chr3138075595138076105E072-13719
chr3138078007138078057E072-11767
chr3138078178138078228E072-11596
chr3138078510138078657E072-11167
chr3138078941138079153E072-10671
chr3138079312138079906E072-9918
chr3138080146138080207E072-9617
chr3138080433138080865E072-8959
chr3138081555138081786E072-8038
chr3138082802138082875E072-6949
chr3138083689138083874E072-5950
chr3138084224138084274E072-5550
chr3138084569138084720E072-5104
chr3138084855138084992E072-4832
chr3138086544138086633E072-3191
chr3138086749138087130E072-2694
chr3138087889138088029E072-1795
chr3138088311138088391E072-1433
chr3138088616138088720E072-1104
chr3138088783138088837E072-987
chr3138090888138090993E0721064
chr3138098686138098736E0728862
chr3138100510138101291E07210686
chr3138101527138101599E07211703
chr3138101617138101667E07211793
chr3138101679138101789E07211855
chr3138102184138102234E07212360
chr3138102491138102541E07212667
chr3138108184138108338E07218360
chr3138108388138108451E07218564
chr3138108544138109616E07218720
chr3138115172138115263E07225348
chr3138115339138115437E07225515
chr3138115631138115760E07225807
chr3138115792138115893E07225968
chr3138116274138116329E07226450
chr3138117700138117801E07227876
chr3138117947138118339E07228123
chr3138118550138119096E07228726
chr3138119156138119206E07229332
chr3138119350138119824E07229526
chr3138051419138051760E073-38064
chr3138051766138051875E073-37949
chr3138069519138069628E073-20196
chr3138069892138070318E073-19506
chr3138070405138070485E073-19339
chr3138070796138070996E073-18828
chr3138071156138071265E073-18559
chr3138075595138076105E073-13719
chr3138078007138078057E073-11767
chr3138078178138078228E073-11596
chr3138078510138078657E073-11167
chr3138078941138079153E073-10671
chr3138079312138079906E073-9918
chr3138080146138080207E073-9617
chr3138080433138080865E073-8959
chr3138081555138081786E073-8038
chr3138082802138082875E073-6949
chr3138083689138083874E073-5950
chr3138084224138084274E073-5550
chr3138084569138084720E073-5104
chr3138084855138084992E073-4832
chr3138085036138085173E073-4651
chr3138085353138085624E073-4200
chr3138086544138086633E073-3191
chr3138086749138087130E073-2694
chr3138087889138088029E073-1795
chr3138088311138088391E073-1433
chr3138088616138088720E073-1104
chr3138088783138088837E073-987
chr3138090472138090782E073648
chr3138096721138097183E0736897
chr3138100510138101291E07310686
chr3138101527138101599E07311703
chr3138101617138101667E07311793
chr3138101679138101789E07311855
chr3138102184138102234E07312360
chr3138102491138102541E07312667
chr3138102606138103081E07312782
chr3138103418138103509E07313594
chr3138108184138108338E07318360
chr3138108388138108451E07318564
chr3138108544138109616E07318720
chr3138114470138114543E07324646
chr3138116274138116329E07326450
chr3138118550138119096E07328726
chr3138119156138119206E07329332
chr3138119350138119824E07329526
chr3138069519138069628E074-20196
chr3138069892138070318E074-19506
chr3138070405138070485E074-19339
chr3138070796138070996E074-18828
chr3138075595138076105E074-13719
chr3138078007138078057E074-11767
chr3138078178138078228E074-11596
chr3138078510138078657E074-11167
chr3138078941138079153E074-10671
chr3138079312138079906E074-9918
chr3138080146138080207E074-9617
chr3138080433138080865E074-8959
chr3138081555138081786E074-8038
chr3138082802138082875E074-6949
chr3138083689138083874E074-5950
chr3138084224138084274E074-5550
chr3138084569138084720E074-5104
chr3138084855138084992E074-4832
chr3138085036138085173E074-4651
chr3138085353138085624E074-4200
chr3138086544138086633E074-3191
chr3138086749138087130E074-2694
chr3138087889138088029E074-1795
chr3138088311138088391E074-1433
chr3138088616138088720E074-1104
chr3138088783138088837E074-987
chr3138098686138098736E0748862
chr3138100510138101291E07410686
chr3138101527138101599E07411703
chr3138101617138101667E07411793
chr3138101679138101789E07411855
chr3138102184138102234E07412360
chr3138102491138102541E07412667
chr3138102606138103081E07412782
chr3138103418138103509E07413594
chr3138114470138114543E07424646
chr3138114708138114905E07424884
chr3138115172138115263E07425348
chr3138115339138115437E07425515
chr3138115631138115760E07425807
chr3138115792138115893E07425968
chr3138116274138116329E07426450
chr3138047245138047544E081-42280
chr3138047582138047622E081-42202
chr3138047674138047728E081-42096
chr3138069519138069628E081-20196
chr3138047245138047544E082-42280
chr3138047582138047622E082-42202
chr3138047674138047728E082-42096










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr3138047895138049064E067-40760
chr3138066350138066453E067-23371
chr3138066481138066623E067-23201
chr3138066694138069477E067-20347
chr3138047895138049064E068-40760
chr3138066350138066453E068-23371
chr3138066481138066623E068-23201
chr3138066694138069477E068-20347
chr3138047895138049064E069-40760
chr3138066350138066453E069-23371
chr3138066481138066623E069-23201
chr3138066694138069477E069-20347
chr3138047895138049064E070-40760
chr3138066350138066453E070-23371
chr3138066481138066623E070-23201
chr3138066694138069477E070-20347
chr3138047895138049064E071-40760
chr3138066350138066453E071-23371
chr3138066481138066623E071-23201
chr3138066694138069477E071-20347
chr3138047895138049064E072-40760
chr3138066350138066453E072-23371
chr3138066481138066623E072-23201
chr3138066694138069477E072-20347
chr3138047895138049064E073-40760
chr3138066350138066453E073-23371
chr3138066481138066623E073-23201
chr3138066694138069477E073-20347
chr3138047895138049064E074-40760
chr3138066350138066453E074-23371
chr3138066481138066623E074-23201
chr3138066694138069477E074-20347
chr3138047895138049064E081-40760
chr3138066481138066623E081-23201
chr3138047895138049064E082-40760
chr3138066350138066453E082-23371
chr3138066481138066623E082-23201
chr3138066694138069477E082-20347