rs12027903

Homo sapiens
G>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0044 (1330/29984,GnomAD)
T=0044 (1283/29118,TOPMED)
T=0058 (289/5008,1000G)
T=0040 (154/3854,ALSPAC)
T=0042 (156/3708,TWINSUK)
chr1:153355280 (GRCh38.p7) (1q21.3)
AD
GWASdb2
1   publication(s)
See rs on genome
6 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 1NC_000001.11:g.153355280G>T
GRCh37.p13 chr 1NC_000001.10:g.153327756G>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.991T=0.009
1000GenomesAmericanSub694G=0.930T=0.070
1000GenomesEast AsianSub1008G=0.906T=0.094
1000GenomesEuropeSub1006G=0.956T=0.044
1000GenomesGlobalStudy-wide5008G=0.942T=0.058
1000GenomesSouth AsianSub978G=0.910T=0.090
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.960T=0.040
The Genome Aggregation DatabaseAfricanSub8728G=0.980T=0.020
The Genome Aggregation DatabaseAmericanSub838G=0.910T=0.090
The Genome Aggregation DatabaseEast AsianSub1618G=0.860T=0.140
The Genome Aggregation DatabaseEuropeSub18498G=0.955T=0.044
The Genome Aggregation DatabaseGlobalStudy-wide29984G=0.955T=0.044
The Genome Aggregation DatabaseOtherSub302G=0.930T=0.070
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.955T=0.044
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.958T=0.042
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs120279030.000427alcohol dependence20201924

eQTL of rs12027903 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs12027903 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr1153357458153357806E07129702
chr1153316817153316869E072-10887
chr1153316931153316999E072-10757
chr1153309110153309174E081-18582
chr1153309218153309562E081-18194
chr1153309218153309562E082-18194