rs12110787

Homo sapiens
A>C
MAP3K4 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0160 (4804/29930,GnomAD)
C=0192 (5595/29118,TOPMED)
C=0221 (1107/5008,1000G)
C=0113 (436/3854,ALSPAC)
C=0114 (423/3708,TWINSUK)
chr6:161053934 (GRCh38.p7) (6q26)
AD
GWASdb2
1   publication(s)
See rs on genome
69 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.161053934A>C
GRCh37.p13 chr 6NC_000006.11:g.161474966A>C

Gene: MAP3K4, mitogen-activated protein kinase kinase kinase 4(plus strand)

Molecule type Change Amino acid[Codon] SO Term
MAP3K4 transcript variant 3NM_001291958.1:c.N/AIntron Variant
MAP3K4 transcript variant 5NM_001301072.1:c.N/AIntron Variant
MAP3K4 transcript variant 1NM_005922.3:c.N/AIntron Variant
MAP3K4 transcript variant 2NM_006724.3:c.N/AIntron Variant
MAP3K4 transcript variant 4NR_120425.1:n.N/AIntron Variant
MAP3K4 transcript variant X1XM_005266989.2:c.N/AIntron Variant
MAP3K4 transcript variant X2XM_017010869.1:c.N/AIntron Variant
MAP3K4 transcript variant X3XR_001743422.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.700C=0.300
1000GenomesAmericanSub694A=0.900C=0.100
1000GenomesEast AsianSub1008A=0.666C=0.334
1000GenomesEuropeSub1006A=0.906C=0.094
1000GenomesGlobalStudy-wide5008A=0.779C=0.221
1000GenomesSouth AsianSub978A=0.780C=0.220
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.887C=0.113
The Genome Aggregation DatabaseAfricanSub8714A=0.741C=0.259
The Genome Aggregation DatabaseAmericanSub834A=0.920C=0.080
The Genome Aggregation DatabaseEast AsianSub1618A=0.645C=0.355
The Genome Aggregation DatabaseEuropeSub18464A=0.898C=0.101
The Genome Aggregation DatabaseGlobalStudy-wide29930A=0.839C=0.160
The Genome Aggregation DatabaseOtherSub300A=0.890C=0.110
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.807C=0.192
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.886C=0.114
PMID Title Author Journal
21956439Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q.Zuo LNeuropsychopharmacology

P-Value

SNP ID p-value Traits Study
rs121107875E-06alcohol dependence21956439

eQTL of rs12110787 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs12110787 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr6161431834161432030E067-42936
chr6161432113161432219E067-42747
chr6161432239161432472E067-42494
chr6161432580161433392E067-41574
chr6161499292161499426E06724326
chr6161433828161433922E068-41044
chr6161433948161434060E068-40906
chr6161434185161434235E068-40731
chr6161434638161434731E068-40235
chr6161434835161434997E068-39969
chr6161488975161489015E06814009
chr6161489263161489330E06814297
chr6161432580161433392E069-41574
chr6161433828161433922E069-41044
chr6161433948161434060E069-40906
chr6161448806161448862E069-26104
chr6161448912161448962E069-26004
chr6161458878161460315E069-14651
chr6161499292161499426E06924326
chr6161499428161499524E06924462
chr6161522655161522846E06947689
chr6161431834161432030E070-42936
chr6161432580161433392E070-41574
chr6161487630161487823E07012664
chr6161487986161488101E07013020
chr6161488975161489015E07014009
chr6161489263161489330E07014297
chr6161489554161489895E07014588
chr6161489898161489975E07014932
chr6161490006161490056E07015040
chr6161431834161432030E071-42936
chr6161432113161432219E071-42747
chr6161432239161432472E071-42494
chr6161432580161433392E071-41574
chr6161433828161433922E071-41044
chr6161433948161434060E071-40906
chr6161458878161460315E071-14651
chr6161488975161489015E07114009
chr6161489263161489330E07114297
chr6161489554161489895E07114588
chr6161432113161432219E072-42747
chr6161432239161432472E072-42494
chr6161432580161433392E072-41574
chr6161458878161460315E072-14651
chr6161499292161499426E07224326
chr6161499428161499524E07224462
chr6161431575161431763E073-43203
chr6161431834161432030E073-42936
chr6161432113161432219E073-42747
chr6161432239161432472E073-42494
chr6161432580161433392E073-41574
chr6161434638161434731E073-40235
chr6161503811161503865E07328845
chr6161431834161432030E074-42936
chr6161432113161432219E074-42747
chr6161432239161432472E074-42494
chr6161432580161433392E074-41574
chr6161433828161433922E074-41044
chr6161433948161434060E074-40906
chr6161434835161434997E074-39969
chr6161458878161460315E074-14651
chr6161488975161489015E07414009
chr6161489263161489330E07414297
chr6161489554161489895E07414588
chr6161499292161499426E07424326
chr6161432580161433392E081-41574
chr6161432580161433392E082-41574
chr6161488975161489015E08214009
chr6161489263161489330E08214297