rs12121677

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0131 (3950/29964,GnomAD)
C=0156 (4547/29118,TOPMED)
C=0161 (804/5008,1000G)
C=0137 (527/3854,ALSPAC)
C=0139 (514/3708,TWINSUK)
chr1:65706287 (GRCh38.p7) (1p31.3)
AD
GWASdb2
1   publication(s)
See rs on genome
58 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 1NC_000001.11:g.65706287T>C
GRCh37.p13 chr 1NC_000001.10:g.66171970T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.856C=0.144
1000GenomesAmericanSub694T=0.790C=0.210
1000GenomesEast AsianSub1008T=0.896C=0.104
1000GenomesEuropeSub1006T=0.868C=0.132
1000GenomesGlobalStudy-wide5008T=0.839C=0.161
1000GenomesSouth AsianSub978T=0.770C=0.230
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.863C=0.137
The Genome Aggregation DatabaseAfricanSub8722T=0.866C=0.134
The Genome Aggregation DatabaseAmericanSub834T=0.820C=0.180
The Genome Aggregation DatabaseEast AsianSub1620T=0.905C=0.095
The Genome Aggregation DatabaseEuropeSub18488T=0.869C=0.130
The Genome Aggregation DatabaseGlobalStudy-wide29964T=0.868C=0.131
The Genome Aggregation DatabaseOtherSub300T=0.800C=0.200
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.843C=0.156
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.861C=0.139
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs121216770.000557alcohol dependence20201924

eQTL of rs12121677 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs12121677 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr16615328766153983E067-17987
chr16615411866154168E067-17802
chr16615419166154231E067-17739
chr16615463366154724E067-17246
chr16615683866156894E067-15076
chr16615711366157558E067-14412
chr16615772866157929E067-14041
chr16615805666158128E067-13842
chr16615313366153236E068-18734
chr16615411866154168E068-17802
chr16615419166154231E068-17739
chr16615683866156894E068-15076
chr16615711366157558E068-14412
chr16615772866157929E068-14041
chr16615805666158128E068-13842
chr16614032266140471E069-31499
chr16615328766153983E069-17987
chr16615411866154168E069-17802
chr16615419166154231E069-17739
chr16615463366154724E069-17246
chr16615683866156894E069-15076
chr16615711366157558E069-14412
chr16615772866157929E069-14041
chr16615805666158128E069-13842
chr16615313366153236E071-18734
chr16615328766153983E071-17987
chr16615411866154168E071-17802
chr16615419166154231E071-17739
chr16615463366154724E071-17246
chr16615683866156894E071-15076
chr16615711366157558E071-14412
chr16615772866157929E071-14041
chr16615805666158128E071-13842
chr16615328766153983E072-17987
chr16615411866154168E072-17802
chr16615419166154231E072-17739
chr16615463366154724E072-17246
chr16615490266154952E072-17018
chr16615683866156894E072-15076
chr16615711366157558E072-14412
chr16615772866157929E072-14041
chr16615805666158128E072-13842
chr16615313366153236E073-18734
chr16615328766153983E073-17987
chr16615411866154168E073-17802
chr16615463366154724E073-17246
chr16615711366157558E073-14412
chr16615772866157929E073-14041
chr16615805666158128E073-13842
chr16615313366153236E074-18734
chr16615328766153983E074-17987
chr16615411866154168E074-17802
chr16615419166154231E074-17739
chr16615463366154724E074-17246
chr16615683866156894E074-15076
chr16615711366157558E074-14412
chr16615772866157929E074-14041
chr16615805666158128E074-13842