rs12146505

Homo sapiens
T>G
LOC107987157 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0087 (2628/29990,GnomAD)
G=0113 (3309/29118,TOPMED)
G=0153 (766/5008,1000G)
G=0041 (158/3854,ALSPAC)
G=0048 (178/3708,TWINSUK)
chr11:1068233 (GRCh38.p7) (11p15.5)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Enhancer around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.1068233T>G
GRCh38.p7 chr 11 alt locus HSCHR11_3_CTG1NT_187681.1:g.142626T>G
GRCh37.p13 chr 11NC_000011.9:g.1068233T>G

Gene: LOC107987157, uncharacterized LOC107987157(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC107987157 transcriptXR_001748091.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.797G=0.203
1000GenomesAmericanSub694T=0.850G=0.150
1000GenomesEast AsianSub1008T=0.781G=0.219
1000GenomesEuropeSub1006T=0.960G=0.040
1000GenomesGlobalStudy-wide5008T=0.847G=0.153
1000GenomesSouth AsianSub978T=0.870G=0.130
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.959G=0.041
The Genome Aggregation DatabaseAfricanSub8726T=0.845G=0.155
The Genome Aggregation DatabaseAmericanSub836T=0.790G=0.210
The Genome Aggregation DatabaseEast AsianSub1616T=0.756G=0.244
The Genome Aggregation DatabaseEuropeSub18510T=0.962G=0.037
The Genome Aggregation DatabaseGlobalStudy-wide29990T=0.912G=0.087
The Genome Aggregation DatabaseOtherSub302T=0.940G=0.060
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.886G=0.113
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.952G=0.048
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs121465050.0000368alcoholismpha002891
rs121465050.0000368alcohol dependence20201924

eQTL of rs12146505 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs12146505 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.