rs12188582

Homo sapiens
A>G
MYO10 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A==0220 (6606/29900,GnomAD)
A==0255 (7429/29118,TOPMED)
A==0295 (1477/5008,1000G)
A==0155 (599/3854,ALSPAC)
A==0152 (564/3708,TWINSUK)
chr5:16818254 (GRCh38.p7) (5p15.1)
AD
GWASdb2
1   publication(s)
See rs on genome
77 Enhancers around
16 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.16818254A>G
GRCh37.p13 chr 5NC_000005.9:g.16818363A>G

Gene: MYO10, myosin X(minus strand)

Molecule type Change Amino acid[Codon] SO Term
MYO10 transcriptNM_012334.2:c.N/AIntron Variant
MYO10 transcript variant X1XM_006714475.2:c.N/AIntron Variant
MYO10 transcript variant X2XM_005248306.4:c.N/AGenic Upstream Transcript Variant
MYO10 transcript variant X4XM_005248307.2:c.N/AGenic Upstream Transcript Variant
MYO10 transcript variant X3XM_011514046.2:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.436G=0.564
1000GenomesAmericanSub694A=0.270G=0.730
1000GenomesEast AsianSub1008A=0.256G=0.744
1000GenomesEuropeSub1006A=0.162G=0.838
1000GenomesGlobalStudy-wide5008A=0.295G=0.705
1000GenomesSouth AsianSub978A=0.300G=0.700
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.155G=0.845
The Genome Aggregation DatabaseAfricanSub8688A=0.378G=0.622
The Genome Aggregation DatabaseAmericanSub836A=0.240G=0.760
The Genome Aggregation DatabaseEast AsianSub1608A=0.265G=0.735
The Genome Aggregation DatabaseEuropeSub18468A=0.141G=0.858
The Genome Aggregation DatabaseGlobalStudy-wide29900A=0.220G=0.779
The Genome Aggregation DatabaseOtherSub300A=0.250G=0.750
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.255G=0.744
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.152G=0.848
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs121885820.000833alcohol dependence20201924

eQTL of rs12188582 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs12188582 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr51678533116785524E067-32839
chr51680933816810567E067-7796
chr51677422216774413E070-43950
chr51678047116780681E070-37682
chr51679191316792024E070-26339
chr51679209616792222E070-26141
chr51679226316792336E070-26027
chr51679235916792450E070-25913
chr51679245516792696E070-25667
chr51679273716793347E070-25016
chr51680933816810567E070-7796
chr51685531116855524E07036948
chr51685563116856123E07037268
chr51678533116785524E071-32839
chr51679122216791858E071-26505
chr51680933816810567E071-7796
chr51683599816836587E07117635
chr51683675816836808E07118395
chr51684136116841691E07122998
chr51678494816784998E072-33365
chr51678533116785524E072-32839
chr51678533116785524E073-32839
chr51680826416808457E073-9906
chr51680913616809322E073-9041
chr51680933816810567E073-7796
chr51684136116841691E07422998
chr51684173316842023E07423370
chr51685563116856123E07437268
chr51678237916782456E081-35907
chr51678308416783134E081-35229
chr51678494816784998E081-33365
chr51678533116785524E081-32839
chr51679122216791858E081-26505
chr51679191316792024E081-26339
chr51679209616792222E081-26141
chr51679226316792336E081-26027
chr51679235916792450E081-25913
chr51679245516792696E081-25667
chr51679273716793347E081-25016
chr51679412216794176E081-24187
chr51679437516794770E081-23593
chr51680002516800189E081-18174
chr51680136416801423E081-16940
chr51680152116801943E081-16420
chr51680678416808043E081-10320
chr51680913616809322E081-9041
chr51680933816810567E081-7796
chr51681077916810839E081-7524
chr51681940616820060E0811043
chr51682026416820464E0811901
chr51683880216839049E08120439
chr51684277416842844E08124411
chr51684290416843065E08124541
chr51684306616843411E08124703
chr51684359816843642E08125235
chr51685784416858042E08139481
chr51685807116858217E08139708
chr51686434716864441E08145984
chr51686464716865280E08146284
chr51686532016865535E08146957
chr51679122216791858E082-26505
chr51679191316792024E082-26339
chr51679209616792222E082-26141
chr51679226316792336E082-26027
chr51679235916792450E082-25913
chr51679245516792696E082-25667
chr51679273716793347E082-25016
chr51679437516794770E082-23593
chr51680678416808043E082-10320
chr51680913616809322E082-9041
chr51680933816810567E082-7796
chr51681940616820060E0821043
chr51683880216839049E08220439
chr51686464716865280E08246284
chr51686532016865535E08246957
chr51686654816866876E08248185
chr51686694116867580E08248578








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr51682652916826787E0678166
chr51682696416827086E0678601
chr51682718816827268E0678825
chr51682652916826787E0688166
chr51682696416827086E0688601
chr51682696416827086E0698601
chr51682718816827268E0698825
chr51682652916826787E0728166
chr51682696416827086E0728601
chr51682718816827268E0728825
chr51682696416827086E0738601
chr51682718816827268E0738825
chr51682696416827086E0818601
chr51682652916826787E0828166
chr51682696416827086E0828601
chr51682718816827268E0828825