rs12191615

Homo sapiens
T>C
AGPAT4 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0101 (11576/114354,ExAC)
C=0129 (3889/29962,GnomAD)
C=0155 (4539/29118,TOPMED)
T==0146 (835/5734,GO-ESP)
C=0110 (552/5008,1000G)
C=0108 (418/3854,ALSPAC)
C=0115 (428/3708,TWINSUK)
chr6:161144126 (GRCh38.p7) (6q26)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.161144126T>C
GRCh37.p13 chr 6NC_000006.11:g.161565158T>C

Gene: AGPAT4, 1-acylglycerol-3-phosphate O-acyltransferase 4(minus strand)

Molecule type Change Amino acid[Codon] SO Term
AGPAT4 transcriptNM_020133.2:c.N/AIntron Variant
AGPAT4 transcript variant X3XM_005267053.3:c.N/AIntron Variant
AGPAT4 transcript variant X1XM_006715514.3:c.N/AIntron Variant
AGPAT4 transcript variant X2XM_017011059.1:c.N/AIntron Variant
AGPAT4 transcript variant X4XR_001743516.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.768C=0.232
1000GenomesAmericanSub694T=0.900C=0.100
1000GenomesEast AsianSub1008T=0.991C=0.009
1000GenomesEuropeSub1006T=0.897C=0.103
1000GenomesGlobalStudy-wide5008T=0.890C=0.110
1000GenomesSouth AsianSub978T=0.930C=0.070
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.892C=0.108
The Exome Aggregation ConsortiumAmericanSub19852T=0.858C=0.141
The Exome Aggregation ConsortiumAsianSub24422T=0.947C=0.052
The Exome Aggregation ConsortiumEuropeSub69224T=0.893C=0.107
The Exome Aggregation ConsortiumGlobalStudy-wide114354T=0.898C=0.101
The Exome Aggregation ConsortiumOtherSub856T=0.910C=0.090
The Genome Aggregation DatabaseAfricanSub8702T=0.792C=0.208
The Genome Aggregation DatabaseAmericanSub838T=0.910C=0.090
The Genome Aggregation DatabaseEast AsianSub1620T=0.990C=0.010
The Genome Aggregation DatabaseEuropeSub18500T=0.894C=0.105
The Genome Aggregation DatabaseGlobalStudy-wide29962T=0.870C=0.129
The Genome Aggregation DatabaseOtherSub302T=0.870C=0.130
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.844C=0.155
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.885C=0.115
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs121916150.000864alcohol dependence20201924

eQTL of rs12191615 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs12191615 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr6161555775161555853E067-9305
chr6161556079161556156E067-9002
chr6161556224161556290E067-8868
chr6161556371161556427E067-8731
chr6161556533161556583E067-8575
chr6161556620161556797E067-8361
chr6161559263161559689E067-5469
chr6161559817161559897E067-5261
chr6161559976161560066E067-5092
chr6161560102161560234E067-4924
chr6161579580161579630E06714422
chr6161581297161581655E06716139
chr6161581768161581850E06716610
chr6161581922161581978E06716764
chr6161582011161582165E06716853
chr6161582220161582270E06717062
chr6161583820161584120E06718662
chr6161584340161584389E06719182
chr6161584584161584878E06719426
chr6161589224161590023E06724066
chr6161590288161590419E06725130
chr6161590532161590588E06725374
chr6161590711161591801E06725553
chr6161592100161592220E06726942
chr6161592282161592345E06727124
chr6161592401161592463E06727243
chr6161602164161602452E06737006
chr6161602733161602838E06737575
chr6161607151161607448E06741993
chr6161607487161607823E06742329
chr6161610297161610366E06745139
chr6161610541161610621E06745383
chr6161610832161610912E06745674
chr6161611166161611216E06746008
chr6161612080161612374E06746922
chr6161555483161555734E068-9424
chr6161555775161555853E068-9305
chr6161556079161556156E068-9002
chr6161556224161556290E068-8868
chr6161556371161556427E068-8731
chr6161556533161556583E068-8575
chr6161556620161556797E068-8361
chr6161556838161557078E068-8080
chr6161557230161557392E068-7766
chr6161557432161557681E068-7477
chr6161557682161557744E068-7414
chr6161560102161560234E068-4924
chr6161583820161584120E06818662
chr6161584340161584389E06819182
chr6161584584161584878E06819426
chr6161589224161590023E06824066
chr6161590288161590419E06825130
chr6161590532161590588E06825374
chr6161590711161591801E06825553
chr6161592100161592220E06826942
chr6161602164161602452E06837006
chr6161602733161602838E06837575
chr6161607151161607448E06841993
chr6161610297161610366E06845139
chr6161610541161610621E06845383
chr6161610832161610912E06845674
chr6161522655161522846E069-42312
chr6161555483161555734E069-9424
chr6161555775161555853E069-9305
chr6161556079161556156E069-9002
chr6161556224161556290E069-8868
chr6161556371161556427E069-8731
chr6161556533161556583E069-8575
chr6161556620161556797E069-8361
chr6161556838161557078E069-8080
chr6161557230161557392E069-7766
chr6161559263161559689E069-5469
chr6161559817161559897E069-5261
chr6161559976161560066E069-5092
chr6161560102161560234E069-4924
chr6161579580161579630E06914422
chr6161581297161581655E06916139
chr6161581768161581850E06916610
chr6161581922161581978E06916764
chr6161582011161582165E06916853
chr6161582220161582270E06917062
chr6161583820161584120E06918662
chr6161584340161584389E06919182
chr6161584584161584878E06919426
chr6161585093161585230E06919935
chr6161586054161586117E06920896
chr6161586356161586444E06921198
chr6161587265161587315E06922107
chr6161587401161587451E06922243
chr6161588785161588835E06923627
chr6161588862161588939E06923704
chr6161588971161589021E06923813
chr6161589224161590023E06924066
chr6161590288161590419E06925130
chr6161590532161590588E06925374
chr6161590711161591801E06925553
chr6161592100161592220E06926942
chr6161592282161592345E06927124
chr6161592401161592463E06927243
chr6161602164161602452E06937006
chr6161602733161602838E06937575
chr6161604870161605007E06939712
chr6161605059161605155E06939901
chr6161610297161610366E06945139
chr6161610541161610621E06945383
chr6161610832161610912E06945674
chr6161611166161611216E06946008
chr6161612080161612374E06946922
chr6161612571161612615E06947413
chr6161612690161612763E06947532
chr6161590288161590419E07025130
chr6161590532161590588E07025374
chr6161590711161591801E07025553
chr6161592100161592220E07026942
chr6161592282161592345E07027124
chr6161555775161555853E071-9305
chr6161556079161556156E071-9002
chr6161556224161556290E071-8868
chr6161556371161556427E071-8731
chr6161556533161556583E071-8575
chr6161556620161556797E071-8361
chr6161556838161557078E071-8080
chr6161557230161557392E071-7766
chr6161557432161557681E071-7477
chr6161559263161559689E071-5469
chr6161559817161559897E071-5261
chr6161559976161560066E071-5092
chr6161560102161560234E071-4924
chr6161560510161560620E071-4538
chr6161560811161561005E071-4153
chr6161561024161561101E071-4057
chr6161579580161579630E07114422
chr6161581297161581655E07116139
chr6161581768161581850E07116610
chr6161581922161581978E07116764
chr6161582718161582802E07117560
chr6161583013161583207E07117855
chr6161583304161583376E07118146
chr6161583571161583643E07118413
chr6161583820161584120E07118662
chr6161584340161584389E07119182
chr6161584584161584878E07119426
chr6161585093161585230E07119935
chr6161586054161586117E07120896
chr6161586356161586444E07121198
chr6161587265161587315E07122107
chr6161587401161587451E07122243
chr6161587830161587870E07122672
chr6161587902161587942E07122744
chr6161588053161588103E07122895
chr6161588238161588288E07123080
chr6161588545161588646E07123387
chr6161588785161588835E07123627
chr6161588862161588939E07123704
chr6161588971161589021E07123813
chr6161589224161590023E07124066
chr6161590288161590419E07125130
chr6161590532161590588E07125374
chr6161590711161591801E07125553
chr6161592100161592220E07126942
chr6161601390161601444E07136232
chr6161602164161602452E07137006
chr6161602733161602838E07137575
chr6161609708161609819E07144550
chr6161609868161609918E07144710
chr6161610297161610366E07145139
chr6161610541161610621E07145383
chr6161610832161610912E07145674
chr6161611166161611216E07146008
chr6161612080161612374E07146922
chr6161555483161555734E072-9424
chr6161555775161555853E072-9305
chr6161556079161556156E072-9002
chr6161556224161556290E072-8868
chr6161556371161556427E072-8731
chr6161556533161556583E072-8575
chr6161556620161556797E072-8361
chr6161556838161557078E072-8080
chr6161557932161557982E072-7176
chr6161559263161559689E072-5469
chr6161559976161560066E072-5092
chr6161560102161560234E072-4924
chr6161560510161560620E072-4538
chr6161581768161581850E07216610
chr6161581922161581978E07216764
chr6161582011161582165E07216853
chr6161582718161582802E07217560
chr6161583013161583207E07217855
chr6161583304161583376E07218146
chr6161583571161583643E07218413
chr6161583820161584120E07218662
chr6161584340161584389E07219182
chr6161584584161584878E07219426
chr6161585093161585230E07219935
chr6161586054161586117E07220896
chr6161587265161587315E07222107
chr6161587401161587451E07222243
chr6161589224161590023E07224066
chr6161590288161590419E07225130
chr6161590532161590588E07225374
chr6161590711161591801E07225553
chr6161592100161592220E07226942
chr6161593236161593312E07228078
chr6161602164161602452E07237006
chr6161602733161602838E07237575
chr6161607487161607823E07242329
chr6161608113161608352E07242955
chr6161610297161610366E07245139
chr6161610541161610621E07245383
chr6161610832161610912E07245674
chr6161611166161611216E07246008
chr6161582220161582270E07317062
chr6161582511161582571E07317353
chr6161582718161582802E07317560
chr6161583013161583207E07317855
chr6161583820161584120E07318662
chr6161584340161584389E07319182
chr6161589224161590023E07324066
chr6161590288161590419E07325130
chr6161590532161590588E07325374
chr6161590711161591801E07325553
chr6161592100161592220E07326942
chr6161602164161602452E07337006
chr6161609708161609819E07344550
chr6161609868161609918E07344710
chr6161610297161610366E07345139
chr6161610541161610621E07345383
chr6161555775161555853E074-9305
chr6161556079161556156E074-9002
chr6161556224161556290E074-8868
chr6161556371161556427E074-8731
chr6161556533161556583E074-8575
chr6161556620161556797E074-8361
chr6161556838161557078E074-8080
chr6161557230161557392E074-7766
chr6161557432161557681E074-7477
chr6161558042161558209E074-6949
chr6161559263161559689E074-5469
chr6161559817161559897E074-5261
chr6161559976161560066E074-5092
chr6161560102161560234E074-4924
chr6161560510161560620E074-4538
chr6161581768161581850E07416610
chr6161581922161581978E07416764
chr6161582011161582165E07416853
chr6161582220161582270E07417062
chr6161582511161582571E07417353
chr6161582718161582802E07417560
chr6161583013161583207E07417855
chr6161583304161583376E07418146
chr6161583571161583643E07418413
chr6161583820161584120E07418662
chr6161584340161584389E07419182
chr6161584584161584878E07419426
chr6161585093161585230E07419935
chr6161586054161586117E07420896
chr6161586356161586444E07421198
chr6161587830161587870E07422672
chr6161587902161587942E07422744
chr6161588053161588103E07422895
chr6161588785161588835E07423627
chr6161588862161588939E07423704
chr6161588971161589021E07423813
chr6161589224161590023E07424066
chr6161590288161590419E07425130
chr6161590532161590588E07425374
chr6161590711161591801E07425553
chr6161592100161592220E07426942
chr6161601390161601444E07436232
chr6161602164161602452E07437006
chr6161602733161602838E07437575
chr6161604870161605007E07439712
chr6161605059161605155E07439901
chr6161605334161605374E07440176
chr6161610297161610366E07445139
chr6161610541161610621E07445383
chr6161610832161610912E07445674
chr6161611166161611216E07446008
chr6161612080161612374E07446922
chr6161612571161612615E07447413
chr6161612690161612763E07447532
chr6161612849161612899E07447691
chr6161612940161612990E07447782
chr6161530998161531048E081-34110
chr6161531097161531364E081-33794
chr6161531427161531477E081-33681
chr6161531482161531662E081-33496
chr6161531764161531924E081-33234
chr6161531935161531995E081-33163
chr6161531996161532160E081-32998
chr6161589224161590023E08124066
chr6161590711161591801E08125553
chr6161609708161609819E08144550
chr6161609868161609918E08144710
chr6161589224161590023E08224066
chr6161590288161590419E08225130
chr6161590532161590588E08225374
chr6161590711161591801E08225553