rs12255578

Homo sapiens
G>T
TCERG1L : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0045 (1352/29956,GnomAD)
T=0048 (1405/29118,TOPMED)
T=0080 (400/5008,1000G)
T=0036 (138/3854,ALSPAC)
T=0030 (112/3708,TWINSUK)
chr10:131144344 (GRCh38.p7) (10q26.3)
ND
GWASdb2
1   publication(s)
See rs on genome
166 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 10NC_000010.11:g.131144344G>T
GRCh37.p13 chr 10NC_000010.10:g.132942607G>T

Gene: TCERG1L, transcription elongation regulator 1 like(minus strand)

Molecule type Change Amino acid[Codon] SO Term
TCERG1L transcriptNM_174937.3:c.N/AIntron Variant
TCERG1L transcript variant X1XM_011539577.1:c.N/AIntron Variant
TCERG1L transcript variant X2XM_011539578.2:c.N/AGenic Downstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.940T=0.060
1000GenomesAmericanSub694G=0.970T=0.030
1000GenomesEast AsianSub1008G=0.910T=0.090
1000GenomesEuropeSub1006G=0.970T=0.030
1000GenomesGlobalStudy-wide5008G=0.920T=0.080
1000GenomesSouth AsianSub978G=0.810T=0.190
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.964T=0.036
The Genome Aggregation DatabaseAfricanSub8714G=0.941T=0.059
The Genome Aggregation DatabaseAmericanSub838G=0.970T=0.030
The Genome Aggregation DatabaseEast AsianSub1622G=0.924T=0.076
The Genome Aggregation DatabaseEuropeSub18480G=0.962T=0.037
The Genome Aggregation DatabaseGlobalStudy-wide29956G=0.954T=0.045
The Genome Aggregation DatabaseOtherSub302G=0.990T=0.010
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.951T=0.048
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.970T=0.030
PMID Title Author Journal
19268276Genome-wide association study of smoking initiation and current smoking.Vink JMAm J Hum Genet

P-Value

SNP ID p-value Traits Study
rs122555780.000242nicotine smoking19268276

eQTL of rs12255578 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs12255578 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr10132907657132907707E067-34900
chr10132907793132907864E067-34743
chr10132907940132908228E067-34379
chr10132908384132908480E067-34127
chr10132929388132929632E067-12975
chr10132929676132930986E067-11621
chr10132930998132931193E067-11414
chr10132943508132943571E067901
chr10132924304132924558E068-18049
chr10132924589132925010E068-17597
chr10132925117132925845E068-16762
chr10132986190132986599E06843583
chr10132907395132907480E069-35127
chr10132907544132907598E069-35009
chr10132907657132907707E069-34900
chr10132907793132907864E069-34743
chr10132942233132942325E069-282
chr10132942591132942631E0690
chr10132942720132942836E069113
chr10132943141132943203E069534
chr10132943217132943285E069610
chr10132943386132943443E069779
chr10132943508132943571E069901
chr10132943672132943722E0691065
chr10132944020132944436E0691413
chr10132977897132978082E06935290
chr10132978135132978185E06935528
chr10132978197132978237E06935590
chr10132986190132986599E06943583
chr10132892787132893426E070-49181
chr10132893747132893851E070-48756
chr10132896754132896848E070-45759
chr10132896895132896945E070-45662
chr10132897058132897120E070-45487
chr10132897154132897543E070-45064
chr10132897587132897658E070-44949
chr10132897749132897813E070-44794
chr10132897853132898000E070-44607
chr10132899078132899142E070-43465
chr10132899279132899415E070-43192
chr10132899712132899805E070-42802
chr10132900594132900753E070-41854
chr10132900760132900814E070-41793
chr10132901031132901381E070-41226
chr10132901588132901649E070-40958
chr10132915028132915108E070-27499
chr10132917031132917147E070-25460
chr10132917337132917476E070-25131
chr10132942591132942631E0700
chr10132942720132942836E070113
chr10132943141132943203E070534
chr10132943217132943285E070610
chr10132943386132943443E070779
chr10132943508132943571E070901
chr10132943672132943722E0701065
chr10132944020132944436E0701413
chr10132977897132978082E07035290
chr10132978135132978185E07035528
chr10132978197132978237E07035590
chr10132986190132986599E07043583
chr10132942233132942325E071-282
chr10132942591132942631E0710
chr10132942720132942836E071113
chr10132943386132943443E071779
chr10132943508132943571E071901
chr10132943672132943722E0711065
chr10132944020132944436E0711413
chr10132986190132986599E07143583
chr10132907657132907707E072-34900
chr10132907793132907864E072-34743
chr10132907940132908228E072-34379
chr10132907395132907480E073-35127
chr10132907544132907598E073-35009
chr10132907657132907707E073-34900
chr10132907793132907864E073-34743
chr10132907940132908228E073-34379
chr10132908384132908480E073-34127
chr10132924304132924558E073-18049
chr10132924589132925010E073-17597
chr10132907657132907707E074-34900
chr10132907793132907864E074-34743
chr10132907940132908228E074-34379
chr10132943386132943443E074779
chr10132943508132943571E074901
chr10132943672132943722E0741065
chr10132892787132893426E081-49181
chr10132893747132893851E081-48756
chr10132894303132894401E081-48206
chr10132896754132896848E081-45759
chr10132896895132896945E081-45662
chr10132897058132897120E081-45487
chr10132897154132897543E081-45064
chr10132897587132897658E081-44949
chr10132897749132897813E081-44794
chr10132897853132898000E081-44607
chr10132898748132898976E081-43631
chr10132899078132899142E081-43465
chr10132899279132899415E081-43192
chr10132899712132899805E081-42802
chr10132900594132900753E081-41854
chr10132900760132900814E081-41793
chr10132901031132901381E081-41226
chr10132901588132901649E081-40958
chr10132907395132907480E081-35127
chr10132907544132907598E081-35009
chr10132907657132907707E081-34900
chr10132907793132907864E081-34743
chr10132907940132908228E081-34379
chr10132908384132908480E081-34127
chr10132914000132914072E081-28535
chr10132914203132914345E081-28262
chr10132915028132915108E081-27499
chr10132915199132915514E081-27093
chr10132918046132918161E081-24446
chr10132918384132918495E081-24112
chr10132923611132923860E081-18747
chr10132924304132924558E081-18049
chr10132924589132925010E081-17597
chr10132925117132925845E081-16762
chr10132929676132930986E081-11621
chr10132930998132931193E081-11414
chr10132941597132942036E081-571
chr10132942233132942325E081-282
chr10132942591132942631E0810
chr10132942720132942836E081113
chr10132943141132943203E081534
chr10132943217132943285E081610
chr10132943386132943443E081779
chr10132943508132943571E081901
chr10132943672132943722E0811065
chr10132944020132944436E0811413
chr10132964881132964986E08122274
chr10132980138132980214E08137531
chr10132897154132897543E082-45064
chr10132897587132897658E082-44949
chr10132897749132897813E082-44794
chr10132897853132898000E082-44607
chr10132899279132899415E082-43192
chr10132899712132899805E082-42802
chr10132900594132900753E082-41854
chr10132900760132900814E082-41793
chr10132901031132901381E082-41226
chr10132901588132901649E082-40958
chr10132907657132907707E082-34900
chr10132907793132907864E082-34743
chr10132907940132908228E082-34379
chr10132908384132908480E082-34127
chr10132915028132915108E082-27499
chr10132915199132915514E082-27093
chr10132917783132917930E082-24677
chr10132918046132918161E082-24446
chr10132918384132918495E082-24112
chr10132918674132918727E082-23880
chr10132918744132918807E082-23800
chr10132918982132919132E082-23475
chr10132923611132923860E082-18747
chr10132924304132924558E082-18049
chr10132924589132925010E082-17597
chr10132941597132942036E082-571
chr10132943141132943203E082534
chr10132943217132943285E082610
chr10132943386132943443E082779
chr10132943508132943571E082901
chr10132965433132965483E08222826
chr10132986190132986599E08243583
chr10132986660132986714E08244053