rs12435601

Homo sapiens
G>T
SLC35F4 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0038 (1152/29980,GnomAD)
T=0039 (1163/29118,TOPMED)
T=0063 (317/5008,1000G)
T=0066 (253/3854,ALSPAC)
T=0061 (226/3708,TWINSUK)
chr14:57979379 (GRCh38.p7) (14q23.1)
AD
GWASdb2
1   publication(s)
See rs on genome
13 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 14NC_000014.9:g.57979379G>T
GRCh37.p13 chr 14NC_000014.8:g.58446097G>T

Gene: SLC35F4, solute carrier family 35 member F4(minus strand)

Molecule type Change Amino acid[Codon] SO Term
SLC35F4 transcript variant 2NM_001206920.1:c.N/AGenic Upstream Transcript Variant
SLC35F4 transcript variant 1NM_001306087.1:c.N/AGenic Upstream Transcript Variant
SLC35F4 transcript variant X4XM_011536723.2:c.N/AIntron Variant
SLC35F4 transcript variant X1XM_011536720.2:c.N/AGenic Upstream Transcript Variant
SLC35F4 transcript variant X3XM_011536721.2:c.N/AGenic Upstream Transcript Variant
SLC35F4 transcript variant X5XM_011536724.2:c.N/AGenic Upstream Transcript Variant
SLC35F4 transcript variant X9XM_011536725.1:c.N/AGenic Upstream Transcript Variant
SLC35F4 transcript variant X2XM_017021258.1:c.N/AGenic Upstream Transcript Variant
SLC35F4 transcript variant X6XM_017021259.1:c.N/AGenic Upstream Transcript Variant
SLC35F4 transcript variant X8XM_017021260.1:c.N/AGenic Upstream Transcript Variant
SLC35F4 transcript variant X10XM_017021261.1:c.N/AGenic Upstream Transcript Variant
SLC35F4 transcript variant X9XR_001750297.1:n.N/AGenic Upstream Transcript Variant
SLC35F4 transcript variant X11XR_001750298.1:n.N/AGenic Upstream Transcript Variant
SLC35F4 transcript variant X12XR_001750299.1:n.N/AGenic Upstream Transcript Variant
SLC35F4 transcript variant X7XR_943418.2:n.N/AGenic Upstream Transcript Variant
SLC35F4 transcript variant X10XR_943419.2:n.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.998T=0.002
1000GenomesAmericanSub694G=0.940T=0.060
1000GenomesEast AsianSub1008G=0.902T=0.098
1000GenomesEuropeSub1006G=0.937T=0.063
1000GenomesGlobalStudy-wide5008G=0.937T=0.063
1000GenomesSouth AsianSub978G=0.890T=0.110
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.934T=0.066
The Genome Aggregation DatabaseAfricanSub8722G=0.989T=0.011
The Genome Aggregation DatabaseAmericanSub838G=0.950T=0.050
The Genome Aggregation DatabaseEast AsianSub1618G=0.892T=0.108
The Genome Aggregation DatabaseEuropeSub18500G=0.955T=0.044
The Genome Aggregation DatabaseGlobalStudy-wide29980G=0.961T=0.038
The Genome Aggregation DatabaseOtherSub302G=0.950T=0.050
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.960T=0.039
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.939T=0.061
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs124356010.000991alcohol consumption (maxi-drinks)24277619

eQTL of rs12435601 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs12435601 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr145842982658429866E067-16231
chr145842995658430244E067-15853
chr145839837358398625E070-47472
chr145842841958428556E070-17541
chr145842891958429728E070-16369
chr145844901558449213E0702918
chr145844949358449620E0703396
chr145842891958429728E072-16369
chr145842982658429866E072-16231
chr145842995658430244E072-15853
chr145845497358455077E0818876
chr145845509958455149E0819002
chr145845531558455402E0819218