rs12437116

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0455 (13612/29908,GnomAD)
C=0456 (13282/29118,TOPMED)
T==0496 (2482/5008,1000G)
C=0493 (1901/3854,ALSPAC)
C=0496 (1840/3708,TWINSUK)
chr14:86225091 (GRCh38.p7) (14q31.3)
AD
GWASdb2
1   publication(s)
See rs on genome
2 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 14NC_000014.9:g.86225091T>C
GRCh37.p13 chr 14NC_000014.8:g.86691435T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.638C=0.362
1000GenomesAmericanSub694T=0.390C=0.610
1000GenomesEast AsianSub1008T=0.367C=0.633
1000GenomesEuropeSub1006T=0.503C=0.497
1000GenomesGlobalStudy-wide5008T=0.496C=0.504
1000GenomesSouth AsianSub978T=0.500C=0.500
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.507C=0.493
The Genome Aggregation DatabaseAfricanSub8700T=0.629C=0.371
The Genome Aggregation DatabaseAmericanSub836T=0.370C=0.630
The Genome Aggregation DatabaseEast AsianSub1606T=0.362C=0.638
The Genome Aggregation DatabaseEuropeSub18464T=0.529C=0.470
The Genome Aggregation DatabaseGlobalStudy-wide29908T=0.544C=0.455
The Genome Aggregation DatabaseOtherSub302T=0.530C=0.470
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.543C=0.456
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.504C=0.496
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs124371160.000783alcohol dependence20201924

eQTL of rs12437116 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs12437116 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr148665103386651163E070-40272
chr148666296686663103E070-28332