rs12439765

Homo sapiens
C>G
SLCO3A1 : Intron Variant
LOC107984747 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0254 (7629/29942,GnomAD)
G=0247 (7215/29118,TOPMED)
G=0285 (1428/5008,1000G)
G=0215 (829/3854,ALSPAC)
G=0217 (804/3708,TWINSUK)
chr15:91992372 (GRCh38.p7) (15q26.1)
ND
GWASdb2
1   publication(s)
See rs on genome
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 15NC_000015.10:g.91992372C>G
GRCh37.p13 chr 15NC_000015.9:g.92535602C>G

Gene: SLCO3A1, solute carrier organic anion transporter family member 3A1(plus strand)

Molecule type Change Amino acid[Codon] SO Term
SLCO3A1 transcript variant 2NM_001145044.1:c.N/AIntron Variant
SLCO3A1 transcript variant 1NM_013272.3:c.N/AIntron Variant
SLCO3A1 transcript variant 3NR_135775.1:n.N/AIntron Variant
SLCO3A1 transcript variant X1XM_005254889.1:c.N/AIntron Variant
SLCO3A1 transcript variant X3XM_005254891.2:c.N/AIntron Variant
SLCO3A1 transcript variant X2XM_011521456.2:c.N/AIntron Variant
SLCO3A1 transcript variant X4XR_931795.1:n.N/AIntron Variant
SLCO3A1 transcript variant X5XR_931796.2:n.N/AIntron Variant

Gene: LOC107984747, uncharacterized LOC107984747(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC107984747 transcriptXR_001751660.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.778G=0.222
1000GenomesAmericanSub694C=0.630G=0.370
1000GenomesEast AsianSub1008C=0.660G=0.340
1000GenomesEuropeSub1006C=0.754G=0.246
1000GenomesGlobalStudy-wide5008C=0.715G=0.285
1000GenomesSouth AsianSub978C=0.710G=0.290
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.785G=0.215
The Genome Aggregation DatabaseAfricanSub8718C=0.767G=0.233
The Genome Aggregation DatabaseAmericanSub838C=0.560G=0.440
The Genome Aggregation DatabaseEast AsianSub1612C=0.679G=0.321
The Genome Aggregation DatabaseEuropeSub18472C=0.748G=0.251
The Genome Aggregation DatabaseGlobalStudy-wide29942C=0.745G=0.254
The Genome Aggregation DatabaseOtherSub302C=0.750G=0.250
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.752G=0.247
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.783G=0.217
PMID Title Author Journal
18227835Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking.Berrettini WMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs124397650.000625nicotine dependence18227835

eQTL of rs12439765 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs12439765 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr159248686792487170E067-48432
chr159248734692487404E067-48198
chr159248742692487529E067-48073
chr159248753692487630E067-47972
chr159248768592487821E067-47781
chr159248787792487917E067-47685
chr159248791892488077E067-47525
chr159248917492489224E067-46378
chr159248928992489426E067-46176
chr159248946492489565E067-46037
chr159248957592489665E067-45937
chr159248967692489732E067-45870
chr159248974892489854E067-45748
chr159249014692492222E067-43380
chr159249229392492455E067-43147
chr159249559192495831E067-39771
chr159249588892496110E067-39492
chr159249614392496383E067-39219
chr159249647192497199E067-38403
chr159249733092497520E067-38082
chr159249753992497883E067-37719
chr159250594792505997E067-29605
chr159250819092508290E067-27312
chr159250858392509865E067-25737
chr159250993392510212E067-25390
chr159251029192510335E067-25267
chr159251058092510630E067-24972
chr159251097792511406E067-24196
chr159251149792511724E067-23878
chr159251185392512133E067-23469
chr159251215892512232E067-23370
chr159251230992512359E067-23243
chr159251291792512962E067-22640
chr159251303492513086E067-22516
chr159251317992514068E067-21534
chr159251652292516604E067-18998
chr159251684592516976E067-18626
chr159251703692517118E067-18484
chr159251731992517392E067-18210
chr159251743092517474E067-18128
chr159251762792517872E067-17730
chr159251799792518050E067-17552
chr159251856692518776E067-16826
chr159251879192519179E067-16423
chr159252901192529068E067-6534
chr159252912192529223E067-6379
chr159253222892532278E067-3324
chr159253229892532439E067-3163
chr159253406192534276E067-1326
chr159253468592534762E067-840
chr159253568292535749E06780
chr159253580792535875E067205
chr159253595292536078E067350
chr159254390092543957E0678298
chr159254400792544394E0678405
chr159254448192544556E0678879
chr159254466892544883E0679066
chr159254493092545052E0679328
chr159254510492545336E0679502
chr159254681692546970E06711214
chr159254710192547229E06711499
chr159254728492547359E06711682
chr159254746392547572E06711861
chr159254767092547720E06712068
chr159254939592549456E06713793
chr159254951992549859E06713917
chr159255004392550103E06714441
chr159255026792550307E06714665
chr159255184292552026E06716240
chr159255205392552142E06716451
chr159255235692552456E06716754
chr159255248792552640E06716885
chr159255266592552753E06717063
chr159255281892552868E06717216
chr159255294292552992E06717340
chr159255318492553298E06717582
chr159255419692554264E06718594
chr159255430792554357E06718705
chr159255454692554639E06718944
chr159255476092555808E06719158
chr159255585692555936E06720254
chr159255613092556193E06720528
chr159255624692556290E06720644
chr159255636192556449E06720759
chr159255647392556523E06720871
chr159255653892556609E06720936
chr159255661492556720E06721012
chr159255698392557033E06721381
chr159255735092557400E06721748
chr159255744392557568E06721841
chr159255762392557828E06722021
chr159255787192557921E06722269
chr159255799192558157E06722389
chr159255888292558941E06723280
chr159255897592559025E06723373
chr159256066092561866E06725058
chr159256502692565076E06729424
chr159256512292565223E06729520
chr159256523692565297E06729634
chr159256543292565485E06729830
chr159256553492565584E06729932
chr159256578692565846E06730184
chr159256591592565971E06730313
chr159257070492570847E06735102
chr159257087392570961E06735271
chr159257112692571253E06735524
chr159257129292571342E06735690
chr159257137492572807E06735772
chr159257297992573495E06737377
chr159257357592573700E06737973
chr159257402292574503E06738420
chr159257456892574700E06738966
chr159257478292574851E06739180
chr159257594792576010E06740345
chr159257649092577126E06740888
chr159257715992577234E06741557
chr159257728392577333E06741681
chr159257894992579035E06743347
chr159257914392579337E06743541
chr159257935792579569E06743755
chr159258442592584475E06748823
chr159258530192585518E06749699
chr159248686792487170E068-48432
chr159248734692487404E068-48198
chr159248742692487529E068-48073
chr159248753692487630E068-47972
chr159248768592487821E068-47781
chr159248787792487917E068-47685
chr159248791892488077E068-47525
chr159248883692488950E068-46652
chr159248917492489224E068-46378
chr159248928992489426E068-46176
chr159248946492489565E068-46037
chr159248957592489665E068-45937
chr159248967692489732E068-45870
chr159248974892489854E068-45748
chr159248987392490079E068-45523
chr159249014692492222E068-43380
chr159249922492500003E068-35599
chr159250819092508290E068-27312
chr159250858392509865E068-25737
chr159250993392510212E068-25390
chr159251029192510335E068-25267
chr159251058092510630E068-24972
chr159251097792511406E068-24196
chr159251149792511724E068-23878
chr159251185392512133E068-23469
chr159251215892512232E068-23370
chr159251230992512359E068-23243
chr159251291792512962E068-22640
chr159251303492513086E068-22516
chr159251317992514068E068-21534
chr159251410192514163E068-21439
chr159251417392514307E068-21295
chr159251452992514579E068-21023
chr159251473292514800E068-20802
chr159251480392514853E068-20749
chr159251500392515096E068-20506
chr159251684592516976E068-18626
chr159251703692517118E068-18484
chr159251731992517392E068-18210
chr159251743092517474E068-18128
chr159251762792517872E068-17730
chr159251799792518050E068-17552
chr159251856692518776E068-16826
chr159251879192519179E068-16423
chr159252251492522653E068-12949
chr159252269492522744E068-12858
chr159252278892522902E068-12700
chr159252295292523125E068-12477
chr159252317692523590E068-12012
chr159252834392528454E068-7148
chr159252880292528852E068-6750
chr159252887592528982E068-6620
chr159253352992533688E068-1914
chr159253373492533860E068-1742
chr159253406192534276E068-1326
chr159254666592546778E06811063
chr159254681692546970E06811214
chr159254710192547229E06811499
chr159254728492547359E06811682
chr159254746392547572E06811861
chr159254767092547720E06812068
chr159254782392547871E06812221
chr159254847292548851E06812870
chr159254897492549028E06813372
chr159254908392549253E06813481
chr159254939592549456E06813793
chr159254951992549859E06813917
chr159255004392550103E06814441
chr159255026792550307E06814665
chr159255062992550716E06815027
chr159255235692552456E06816754
chr159255248792552640E06816885
chr159255266592552753E06817063
chr159255281892552868E06817216
chr159255294292552992E06817340
chr159255318492553298E06817582
chr159255357092553645E06817968
chr159255419692554264E06818594
chr159255430792554357E06818705
chr159255454692554639E06818944
chr159255476092555808E06819158
chr159255585692555936E06820254
chr159255613092556193E06820528
chr159255624692556290E06820644
chr159255636192556449E06820759
chr159255647392556523E06820871
chr159255653892556609E06820936
chr159255661492556720E06821012
chr159255698392557033E06821381
chr159255735092557400E06821748
chr159255744392557568E06821841
chr159255762392557828E06822021
chr159255787192557921E06822269
chr159255799192558157E06822389
chr159256212292562524E06826520
chr159256502692565076E06829424
chr159256512292565223E06829520
chr159256523692565297E06829634
chr159256722792567435E06831625
chr159256743892567521E06831836
chr159256766492567708E06832062
chr159256860592568880E06833003
chr159256899292569271E06833390
chr159256946492569514E06833862
chr159256954692569586E06833944
chr159257649092577126E06840888
chr159257715992577234E06841557
chr159257728392577333E06841681
chr159258442592584475E06848823
chr159258514892585198E06849546
chr159258530192585518E06849699
chr159248686792487170E069-48432
chr159248734692487404E069-48198
chr159248742692487529E069-48073
chr159248753692487630E069-47972
chr159248768592487821E069-47781
chr159248787792487917E069-47685
chr159248791892488077E069-47525
chr159248917492489224E069-46378
chr159248928992489426E069-46176
chr159248946492489565E069-46037
chr159248957592489665E069-45937
chr159248967692489732E069-45870
chr159248974892489854E069-45748
chr159248987392490079E069-45523
chr159249014692492222E069-43380
chr159249229392492455E069-43147
chr159249330292493713E069-41889
chr159249647192497199E069-38403
chr159249794192498026E069-37576
chr159249814592498252E069-37350
chr159249834492498394E069-37208
chr159249841792498508E069-37094
chr159249909192499223E069-36379
chr159250574692505822E069-29780
chr159250594792505997E069-29605
chr159250603692506123E069-29479
chr159250819092508290E069-27312
chr159250858392509865E069-25737
chr159250993392510212E069-25390
chr159251029192510335E069-25267
chr159251058092510630E069-24972
chr159251097792511406E069-24196
chr159251149792511724E069-23878
chr159251185392512133E069-23469
chr159251215892512232E069-23370
chr159251230992512359E069-23243
chr159251291792512962E069-22640
chr159251303492513086E069-22516
chr159251317992514068E069-21534
chr159251410192514163E069-21439
chr159251417392514307E069-21295
chr159251452992514579E069-21023
chr159251473292514800E069-20802
chr159251480392514853E069-20749
chr159251641392516486E069-19116
chr159251652292516604E069-18998
chr159251684592516976E069-18626
chr159251703692517118E069-18484
chr159251731992517392E069-18210
chr159251743092517474E069-18128
chr159251762792517872E069-17730
chr159251799792518050E069-17552
chr159251856692518776E069-16826
chr159251879192519179E069-16423
chr159252317692523590E069-12012
chr159252422292524371E069-11231
chr159252834392528454E069-7148
chr159252851092528560E069-7042
chr159252880292528852E069-6750
chr159252887592528982E069-6620
chr159253332192533401E069-2201
chr159253352992533688E069-1914
chr159253373492533860E069-1742
chr159253406192534276E069-1326
chr159253540092535450E069-152
chr159253568292535749E06980
chr159253580792535875E069205
chr159253595292536078E069350
chr159253609092536208E069488
chr159253625592536543E069653
chr159253662592536706E0691023
chr159253802792538106E0692425
chr159253866492538704E0693062
chr159254390092543957E0698298
chr159254400792544394E0698405
chr159254466892544883E0699066
chr159254641892546483E06910816
chr159254652692546596E06910924
chr159254666592546778E06911063
chr159254681692546970E06911214
chr159254710192547229E06911499
chr159254728492547359E06911682
chr159254746392547572E06911861
chr159254767092547720E06912068
chr159254782392547871E06912221
chr159254908392549253E06913481
chr159254939592549456E06913793
chr159254951992549859E06913917
chr159255004392550103E06914441
chr159255026792550307E06914665
chr159255062992550716E06915027
chr159255281892552868E06917216
chr159255294292552992E06917340
chr159255318492553298E06917582
chr159255357092553645E06917968
chr159255419692554264E06918594
chr159255430792554357E06918705
chr159255454692554639E06918944
chr159255476092555808E06919158
chr159255585692555936E06920254
chr159255613092556193E06920528
chr159255624692556290E06920644
chr159255636192556449E06920759
chr159255647392556523E06920871
chr159255653892556609E06920936
chr159255661492556720E06921012
chr159255698392557033E06921381
chr159255735092557400E06921748
chr159255744392557568E06921841
chr159255762392557828E06922021
chr159255787192557921E06922269
chr159255799192558157E06922389
chr159255888292558941E06923280
chr159255897592559025E06923373
chr159255968892559766E06924086
chr159255990392559953E06924301
chr159256033292560400E06924730
chr159256066092561866E06925058
chr159256212292562524E06926520
chr159256282392562888E06927221
chr159256293292562996E06927330
chr159256311392563165E06927511
chr159256317292563257E06927570
chr159256722792567435E06931625
chr159256743892567521E06931836
chr159256766492567708E06932062
chr159256812792568224E06932525
chr159256840492568452E06932802
chr159256860592568880E06933003
chr159256899292569271E06933390
chr159256946492569514E06933862
chr159256954692569586E06933944
chr159257297992573495E06937377
chr159257357592573700E06937973
chr159257402292574503E06938420
chr159257456892574700E06938966
chr159257478292574851E06939180
chr159257511392575157E06939511
chr159257524292575284E06939640
chr159257552592575575E06939923
chr159257594792576010E06940345
chr159257649092577126E06940888
chr159257715992577234E06941557
chr159257728392577333E06941681
chr159257761392577718E06942011
chr159257894992579035E06943347
chr159257914392579337E06943541
chr159257935792579569E06943755
chr159258471392584962E06949111
chr159258514892585198E06949546
chr159258530192585518E06949699
chr159254400792544394E0708405
chr159254448192544556E0708879
chr159254466892544883E0709066
chr159254493092545052E0709328
chr159248686792487170E071-48432
chr159248734692487404E071-48198
chr159248742692487529E071-48073
chr159248753692487630E071-47972
chr159248768592487821E071-47781
chr159248787792487917E071-47685
chr159248791892488077E071-47525
chr159248917492489224E071-46378
chr159248928992489426E071-46176
chr159248946492489565E071-46037
chr159248957592489665E071-45937
chr159248967692489732E071-45870
chr159248974892489854E071-45748
chr159248987392490079E071-45523
chr159249014692492222E071-43380
chr159249229392492455E071-43147
chr159249272892492809E071-42793
chr159249287292492922E071-42680
chr159249295092492990E071-42612
chr159249330292493713E071-41889
chr159249380892494561E071-41041
chr159249457492494728E071-40874
chr159249513492495203E071-40399
chr159249559192495831E071-39771
chr159249588892496110E071-39492
chr159249614392496383E071-39219
chr159249647192497199E071-38403
chr159249733092497520E071-38082
chr159249753992497883E071-37719
chr159249794192498026E071-37576
chr159249814592498252E071-37350
chr159249834492498394E071-37208
chr159249841792498508E071-37094
chr159249896992499036E071-36566
chr159249909192499223E071-36379
chr159250453092504879E071-30723
chr159250492892504982E071-30620
chr159250501292505088E071-30514
chr159250574692505822E071-29780
chr159250594792505997E071-29605
chr159250603692506123E071-29479
chr159250742492507474E071-28128
chr159250751192507585E071-28017
chr159250763492507689E071-27913
chr159250819092508290E071-27312
chr159250858392509865E071-25737
chr159250993392510212E071-25390
chr159251029192510335E071-25267
chr159251058092510630E071-24972
chr159251097792511406E071-24196
chr159251149792511724E071-23878
chr159251185392512133E071-23469
chr159251215892512232E071-23370
chr159251230992512359E071-23243
chr159251291792512962E071-22640
chr159251303492513086E071-22516
chr159251317992514068E071-21534
chr159251410192514163E071-21439
chr159251417392514307E071-21295
chr159251452992514579E071-21023
chr159251473292514800E071-20802
chr159251480392514853E071-20749
chr159251500392515096E071-20506
chr159251553092515610E071-19992
chr159251568692515730E071-19872
chr159251641392516486E071-19116
chr159251652292516604E071-18998
chr159251684592516976E071-18626
chr159251703692517118E071-18484
chr159251731992517392E071-18210
chr159251743092517474E071-18128
chr159251762792517872E071-17730
chr159251799792518050E071-17552
chr159251856692518776E071-16826
chr159251879192519179E071-16423
chr159252278892522902E071-12700
chr159252295292523125E071-12477
chr159252317692523590E071-12012
chr159252422292524371E071-11231
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chr159254390092543957E0818298
chr159254400792544394E0818405
chr159254448192544556E0818879
chr159254466892544883E0819066
chr159254493092545052E0819328
chr159254510492545336E0819502
chr159254681692546970E08111214
chr159255476092555808E08119158
chr159256812792568224E08132525
chr159256840492568452E08132802
chr159257112692571253E08135524
chr159257129292571342E08135690
chr159257137492572807E08135772
chr159257649092577126E08140888
chr159257715992577234E08141557
chr159257728392577333E08141681
chr159257761392577718E08142011
chr159249014692492222E082-43380
chr159254400792544394E0828405
chr159254448192544556E0828879
chr159254466892544883E0829066
chr159255430792554357E08218705
chr159255476092555808E08219158