rs12446921

Homo sapiens
A>G
PARN : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0218 (6532/29946,GnomAD)
G=0202 (5897/29118,TOPMED)
G=0136 (679/5008,1000G)
G=0255 (984/3854,ALSPAC)
G=0257 (953/3708,TWINSUK)
chr16:14535631 (GRCh38.p7) (16p13.12)
AD
GWASdb2
1   publication(s)
See rs on genome
134 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 16NC_000016.10:g.14535631A>G
GRCh37.p13 chr 16NC_000016.9:g.14629488A>G
PARN RefSeqGeneNG_042871.1:g.99641T>C
GRCh38.p7 chr 16 alt locus HSCHR16_1_CTG1NT_187607.1:g.108488A>G

Gene: PARN, poly(A)-specific ribonuclease(minus strand)

Molecule type Change Amino acid[Codon] SO Term
PARN transcript variant 2NM_001134477.2:c.N/AIntron Variant
PARN transcript variant 3NM_001242992.1:c.N/AIntron Variant
PARN transcript variant 1NM_002582.3:c.N/AIntron Variant
PARN transcript variant X1XM_011522510.2:c.N/AIntron Variant
PARN transcript variant X2XM_011522511.2:c.N/AIntron Variant
PARN transcript variant X4XM_011522513.2:c.N/AIntron Variant
PARN transcript variant X3XM_017023258.1:c.N/AIntron Variant
PARN transcript variant X8XM_017023259.1:c.N/AIntron Variant
PARN transcript variant X10XM_017023260.1:c.N/AIntron Variant
PARN transcript variant X5XM_011522514.1:c.N/AGenic Downstream Transcript Variant
PARN transcript variant X6XR_001751906.1:n.N/AIntron Variant
PARN transcript variant X7XR_001751907.1:n.N/AGenic Downstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.880G=0.120
1000GenomesAmericanSub694A=0.860G=0.140
1000GenomesEast AsianSub1008A=0.992G=0.008
1000GenomesEuropeSub1006A=0.741G=0.259
1000GenomesGlobalStudy-wide5008A=0.864G=0.136
1000GenomesSouth AsianSub978A=0.840G=0.160
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.745G=0.255
The Genome Aggregation DatabaseAfricanSub8720A=0.863G=0.137
The Genome Aggregation DatabaseAmericanSub836A=0.860G=0.140
The Genome Aggregation DatabaseEast AsianSub1622A=0.996G=0.004
The Genome Aggregation DatabaseEuropeSub18466A=0.723G=0.276
The Genome Aggregation DatabaseGlobalStudy-wide29946A=0.781G=0.218
The Genome Aggregation DatabaseOtherSub302A=0.660G=0.340
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.797G=0.202
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.743G=0.257
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs124469210.000868alcohol dependence20201924

eQTL of rs12446921 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs12446921 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr161458389514583998E067-45490
chr161458408514584132E067-45356
chr161458414214584525E067-44963
chr161459517114596606E067-32882
chr161461284314612915E067-16573
chr161461313414613257E067-16231
chr161461329014613460E067-16028
chr161462276914623689E067-5799
chr161465366814653848E06724180
chr161465391414654087E06724426
chr161465659014657041E06727102
chr161465704214657317E06727554
chr161466026214660371E06730774
chr161466098014661177E06731492
chr161466127714661363E06731789
chr161458602814586196E068-43292
chr161458630914586533E068-42955
chr161459517114596606E068-32882
chr161459668714596849E068-32639
chr161459691914597753E068-31735
chr161459775714597868E068-31620
chr161460860414608719E068-20769
chr161462090714621170E068-8318
chr161465659014657041E06827102
chr161465704214657317E06827554
chr161465741014657527E06827922
chr161465772414657778E06828236
chr161465794814658052E06828460
chr161465816814658245E06828680
chr161465825214658531E06828764
chr161465856814659622E06829080
chr161466009514660191E06830607
chr161466026214660371E06830774
chr161466041114660480E06830923
chr161459078514590906E069-38582
chr161459091614590953E069-38535
chr161459462414594695E069-34793
chr161459517114596606E069-32882
chr161465366814653848E06924180
chr161465391414654087E06924426
chr161465417314654253E06924685
chr161466009514660191E06930607
chr161466026214660371E06930774
chr161466041114660480E06930923
chr161466063014660777E06931142
chr161464356314644036E07014075
chr161458992514590757E071-38731
chr161459078514590906E071-38582
chr161459091614590953E071-38535
chr161459462414594695E071-34793
chr161459476314594898E071-34590
chr161459490014595112E071-34376
chr161459517114596606E071-32882
chr161459668714596849E071-32639
chr161461284314612915E071-16573
chr161461313414613257E071-16231
chr161461329014613460E071-16028
chr161462121014622021E071-7467
chr161462209414622721E071-6767
chr161462276914623689E071-5799
chr161463315014633279E0713662
chr161463336414633475E0713876
chr161463356314633793E0714075
chr161463393114633991E0714443
chr161465366814653848E07124180
chr161465391414654087E07124426
chr161465417314654253E07124685
chr161465441914654488E07124931
chr161465449914654600E07125011
chr161466026214660371E07130774
chr161466041114660480E07130923
chr161466063014660777E07131142
chr161459078514590906E072-38582
chr161459091614590953E072-38535
chr161459099214591683E072-37805
chr161459434914594402E072-35086
chr161459462414594695E072-34793
chr161459476314594898E072-34590
chr161459490014595112E072-34376
chr161459517114596606E072-32882
chr161461032214610390E072-19098
chr161465659014657041E07227102
chr161465704214657317E07227554
chr161466009514660191E07230607
chr161466026214660371E07230774
chr161466041114660480E07230923
chr161466063014660777E07231142
chr161458602814586196E073-43292
chr161458630914586533E073-42955
chr161459517114596606E073-32882
chr161461722314617405E073-12083
chr161461763714617798E073-11690
chr161465366814653848E07324180
chr161465391414654087E07324426
chr161465417314654253E07324685
chr161465659014657041E07327102
chr161465704214657317E07327554
chr161465741014657527E07327922
chr161465772414657778E07328236
chr161465794814658052E07328460
chr161465816814658245E07328680
chr161465825214658531E07328764
chr161465856814659622E07329080
chr161466009514660191E07330607
chr161466026214660371E07330774
chr161466041114660480E07330923
chr161466063014660777E07331142
chr161459078514590906E074-38582
chr161459091614590953E074-38535
chr161459099214591683E074-37805
chr161459434914594402E074-35086
chr161459462414594695E074-34793
chr161459476314594898E074-34590
chr161459490014595112E074-34376
chr161459517114596606E074-32882
chr161461382414613929E074-15559
chr161461722314617405E074-12083
chr161461763714617798E074-11690
chr161462209414622721E074-6767
chr161465659014657041E07427102
chr161465704214657317E07427554
chr161466009514660191E07430607
chr161466026214660371E07430774
chr161466581114665861E07436323
chr161459091614590953E081-38535
chr161465366814653848E08124180
chr161465391414654087E08124426
chr161465417314654253E08124685
chr161465816814658245E08128680
chr161465825214658531E08128764
chr161465856814659622E08129080
chr161466009514660191E08130607
chr161466026214660371E08130774
chr161466009514660191E08230607