rs12517913

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0415 (12387/29832,GnomAD)
T=0411 (11980/29118,TOPMED)
T=0426 (2135/5008,1000G)
T=0416 (1605/3854,ALSPAC)
T=0424 (1573/3708,TWINSUK)
chr5:178078794 (GRCh38.p7) (5q35.3)
OD
GWASdb2
1   publication(s)
See rs on genome
9 Enhancers around
6 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.178078794C>T
GRCh37.p13 chr 5NC_000005.9:g.177505795C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.613T=0.387
1000GenomesAmericanSub694C=0.520T=0.480
1000GenomesEast AsianSub1008C=0.545T=0.455
1000GenomesEuropeSub1006C=0.565T=0.435
1000GenomesGlobalStudy-wide5008C=0.574T=0.426
1000GenomesSouth AsianSub978C=0.600T=0.400
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.584T=0.416
The Genome Aggregation DatabaseAfricanSub8684C=0.629T=0.371
The Genome Aggregation DatabaseAmericanSub828C=0.520T=0.480
The Genome Aggregation DatabaseEast AsianSub1606C=0.560T=0.440
The Genome Aggregation DatabaseEuropeSub18412C=0.568T=0.431
The Genome Aggregation DatabaseGlobalStudy-wide29832C=0.584T=0.415
The Genome Aggregation DatabaseOtherSub302C=0.580T=0.420
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.588T=0.411
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.576T=0.424
PMID Title Author Journal
23183491Genome-wide association study identifies a potent locus associated with human opioid sensitivity.Nishizawa DMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs125179130.000321Opioid sensitivity23183491

eQTL of rs12517913 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr5:177505795FAM153CENSG00000204677.6C>T1.0134e-1472389Cerebellum
Chr5:177505795RP11-889L3.1ENSG00000218227.3C>T3.7129e-1923190Cerebellum
Chr5:177505795FAM153CENSG00000204677.6C>T1.1087e-1372389Cerebellar_Hemisphere
Chr5:177505795FAM153CENSG00000204677.6C>T2.8129e-772389Caudate_basal_ganglia

meQTL of rs12517913 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr5177550157177550207E06744362
chr5177550157177550207E06944362
chr5177546443177546598E07040648
chr5177501601177501907E071-3888
chr5177547262177549077E07241467
chr5177550157177550207E07344362
chr5177551210177551810E07345415
chr5177551936177552072E07346141
chr5177550770177551084E08244975







Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr5177539938177540813E06934143
chr5177539938177540813E07034143
chr5177539938177540813E07134143
chr5177539938177540813E07234143
chr5177539938177540813E07334143
chr5177539938177540813E08234143