rs12526737

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0215 (6448/29944,GnomAD)
C=0210 (6122/29118,TOPMED)
C=0240 (1204/5008,1000G)
C=0209 (804/3854,ALSPAC)
C=0195 (724/3708,TWINSUK)
chr6:154387499 (GRCh38.p7) (6q25.2)
AD
GWASdb2
1   publication(s)
See rs on genome
205 Enhancers around
8 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.154387499T>C
GRCh37.p13 chr 6NC_000006.11:g.154708633T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.771C=0.229
1000GenomesAmericanSub694T=0.820C=0.180
1000GenomesEast AsianSub1008T=0.623C=0.377
1000GenomesEuropeSub1006T=0.829C=0.171
1000GenomesGlobalStudy-wide5008T=0.760C=0.240
1000GenomesSouth AsianSub978T=0.770C=0.230
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.791C=0.209
The Genome Aggregation DatabaseAfricanSub8710T=0.781C=0.219
The Genome Aggregation DatabaseAmericanSub838T=0.800C=0.200
The Genome Aggregation DatabaseEast AsianSub1608T=0.593C=0.407
The Genome Aggregation DatabaseEuropeSub18486T=0.802C=0.197
The Genome Aggregation DatabaseGlobalStudy-wide29944T=0.784C=0.215
The Genome Aggregation DatabaseOtherSub302T=0.800C=0.200
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.789C=0.210
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.805C=0.195
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs125267370.000581alcohol dependence20201924

eQTL of rs12526737 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs12526737 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr6154691390154691470E067-17163
chr6154691660154691717E067-16916
chr6154691755154692180E067-16453
chr6154692247154692306E067-16327
chr6154715272154715444E0676639
chr6154715455154715515E0676822
chr6154715563154716113E0676930
chr6154716121154716248E0677488
chr6154724832154725281E06716199
chr6154729639154729846E06721006
chr6154730021154730242E06721388
chr6154731137154731188E06722504
chr6154731217154731267E06722584
chr6154731310154732521E06722677
chr6154732835154733306E06724202
chr6154733386154733505E06724753
chr6154733588154733659E06724955
chr6154748609154748869E06739976
chr6154751586154751991E06742953
chr6154752118154752172E06743485
chr6154715142154715207E0686509
chr6154715272154715444E0686639
chr6154715455154715515E0686822
chr6154715563154716113E0686930
chr6154716121154716248E0687488
chr6154716432154716542E0687799
chr6154716580154716656E0687947
chr6154716672154716703E0688039
chr6154717230154717281E0688597
chr6154724832154725281E06816199
chr6154729639154729846E06821006
chr6154730021154730242E06821388
chr6154730254154730351E06821621
chr6154730483154730613E06821850
chr6154730714154730786E06822081
chr6154731137154731188E06822504
chr6154731217154731267E06822584
chr6154731310154732521E06822677
chr6154732835154733306E06824202
chr6154733386154733505E06824753
chr6154733588154733659E06824955
chr6154733699154733854E06825066
chr6154713868154713975E0695235
chr6154715142154715207E0696509
chr6154715272154715444E0696639
chr6154715455154715515E0696822
chr6154715563154716113E0696930
chr6154716121154716248E0697488
chr6154716432154716542E0697799
chr6154716580154716656E0697947
chr6154716672154716703E0698039
chr6154716764154716815E0698131
chr6154719430154719512E06910797
chr6154719571154719667E06910938
chr6154720260154720637E06911627
chr6154720695154720841E06912062
chr6154724832154725281E06916199
chr6154729639154729846E06921006
chr6154730021154730242E06921388
chr6154730254154730351E06921621
chr6154730483154730613E06921850
chr6154730714154730786E06922081
chr6154731137154731188E06922504
chr6154731217154731267E06922584
chr6154731310154732521E06922677
chr6154732835154733306E06924202
chr6154733386154733505E06924753
chr6154733588154733659E06924955
chr6154733699154733854E06925066
chr6154750826154750876E06942193
chr6154750979154751049E06942346
chr6154751079154751306E06942446
chr6154754948154755420E06946315
chr6154692247154692306E070-16327
chr6154692516154692614E070-16019
chr6154692619154692989E070-15644
chr6154724832154725281E07016199
chr6154725544154725594E07016911
chr6154725633154725715E07017000
chr6154662193154662292E071-46341
chr6154680889154681091E071-27542
chr6154691390154691470E071-17163
chr6154691660154691717E071-16916
chr6154691755154692180E071-16453
chr6154692247154692306E071-16327
chr6154715142154715207E0716509
chr6154715272154715444E0716639
chr6154715455154715515E0716822
chr6154715563154716113E0716930
chr6154716121154716248E0717488
chr6154716432154716542E0717799
chr6154716580154716656E0717947
chr6154716672154716703E0718039
chr6154716764154716815E0718131
chr6154719571154719667E07110938
chr6154720260154720637E07111627
chr6154720695154720841E07112062
chr6154729639154729846E07121006
chr6154730021154730242E07121388
chr6154730254154730351E07121621
chr6154731137154731188E07122504
chr6154731217154731267E07122584
chr6154731310154732521E07122677
chr6154732835154733306E07124202
chr6154733386154733505E07124753
chr6154746297154747071E07137664
chr6154747837154748432E07139204
chr6154750979154751049E07142346
chr6154751079154751306E07142446
chr6154751586154751991E07142953
chr6154752118154752172E07143485
chr6154754948154755420E07146315
chr6154715142154715207E0726509
chr6154715272154715444E0726639
chr6154715455154715515E0726822
chr6154715563154716113E0726930
chr6154716121154716248E0727488
chr6154719430154719512E07210797
chr6154719571154719667E07210938
chr6154720260154720637E07211627
chr6154720695154720841E07212062
chr6154721079154721485E07212446
chr6154724832154725281E07216199
chr6154729639154729846E07221006
chr6154730021154730242E07221388
chr6154731137154731188E07222504
chr6154731217154731267E07222584
chr6154731310154732521E07222677
chr6154732835154733306E07224202
chr6154733386154733505E07224753
chr6154733588154733659E07224955
chr6154733699154733854E07225066
chr6154751079154751306E07242446
chr6154751586154751991E07242953
chr6154754509154754877E07245876
chr6154754948154755420E07246315
chr6154719430154719512E07310797
chr6154724832154725281E07316199
chr6154730254154730351E07321621
chr6154730483154730613E07321850
chr6154731137154731188E07322504
chr6154731217154731267E07322584
chr6154731310154732521E07322677
chr6154732835154733306E07324202
chr6154733386154733505E07324753
chr6154733588154733659E07324955
chr6154756582154756920E07347949
chr6154756993154757067E07348360
chr6154757191154757241E07348558
chr6154691755154692180E074-16453
chr6154713868154713975E0745235
chr6154715142154715207E0746509
chr6154715272154715444E0746639
chr6154715455154715515E0746822
chr6154715563154716113E0746930
chr6154716121154716248E0747488
chr6154716432154716542E0747799
chr6154716580154716656E0747947
chr6154716672154716703E0748039
chr6154716764154716815E0748131
chr6154719430154719512E07410797
chr6154719571154719667E07410938
chr6154720260154720637E07411627
chr6154720695154720841E07412062
chr6154724832154725281E07416199
chr6154729639154729846E07421006
chr6154730021154730242E07421388
chr6154731217154731267E07422584
chr6154731310154732521E07422677
chr6154732835154733306E07424202
chr6154733386154733505E07424753
chr6154733588154733659E07424955
chr6154746297154747071E07437664
chr6154750826154750876E07442193
chr6154750979154751049E07442346
chr6154751079154751306E07442446
chr6154751586154751991E07442953
chr6154754509154754877E07445876
chr6154754948154755420E07446315
chr6154755880154756077E07447247
chr6154675496154675546E081-33087
chr6154679267154679457E081-29176
chr6154679515154679601E081-29032
chr6154679801154679851E081-28782
chr6154680889154681091E081-27542
chr6154684204154684254E081-24379
chr6154684433154684483E081-24150
chr6154690962154691016E081-17617
chr6154691390154691470E081-17163
chr6154691660154691717E081-16916
chr6154691755154692180E081-16453
chr6154731310154732521E08122677
chr6154679267154679457E082-29176
chr6154679515154679601E082-29032
chr6154679801154679851E082-28782
chr6154684433154684483E082-24150
chr6154684857154685039E082-23594
chr6154685122154685236E082-23397
chr6154685446154685531E082-23102
chr6154691660154691717E082-16916
chr6154691755154692180E082-16453
chr6154731310154732521E08222677
chr6154732835154733306E08224202
chr6154733386154733505E08224753
chr6154733588154733659E08224955










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr6154680235154680773E067-27860
chr6154680235154680773E068-27860
chr6154680235154680773E070-27860
chr6154680235154680773E071-27860
chr6154680235154680773E072-27860
chr6154680235154680773E073-27860
chr6154680235154680773E074-27860
chr6154680235154680773E082-27860