SNP Detail Info-rs12573768

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A=0104 (3131/29938,GnomAD)
A=0117 (3425/29118,TOPMED)
A=0177 (886/5008,1000G)
A=0057 (221/3854,ALSPAC)
A=0055 (205/3708,TWINSUK)

Position: chr10:73004316 (GRCh38.p7) (10q22.1)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 8 Enhancers around

Promoter: 0 Promoter around

Sequence Name	Change(s)
GRCh38.p7 chr 10	NC_000010.11:g.73004316G>A
GRCh37.p13 chr 10	NC_000010.10:g.74764074G>A

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.831	A=0.169
1000Genomes	American	Sub	694	G=0.900	A=0.100
1000Genomes	East Asian	Sub	1008	G=0.698	A=0.302
1000Genomes	Europe	Sub	1006	G=0.946	A=0.054
1000Genomes	Global	Study-wide	5008	G=0.823	A=0.177
1000Genomes	South Asian	Sub	978	G=0.760	A=0.240
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.943	A=0.057
The Genome Aggregation Database	African	Sub	8716	G=0.835	A=0.165
The Genome Aggregation Database	American	Sub	836	G=0.920	A=0.080
The Genome Aggregation Database	East Asian	Sub	1616	G=0.704	A=0.296
The Genome Aggregation Database	Europe	Sub	18468	G=0.939	A=0.060
The Genome Aggregation Database	Global	Study-wide	29938	G=0.895	A=0.104
The Genome Aggregation Database	Other	Sub	302	G=0.900	A=0.100
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.882	A=0.117
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.945	A=0.055

PMID	Title	Author	Journal
20201924	Genome-wide association study of alcohol dependence implicates a region on chromosome 11.	Edenberg HJ	Alcohol Clin Exp Res

SNP ID	p-value	Traits	Study
rs12573768	0.00059	alcohol dependence	20201924

eQTL of rs12573768 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
Chr10:74764074	NUDT13	ENSG00000166321.9	G>A	3.0485e-6	-106143	Cerebellum
Chr10:74764074	TTC18	ENSG00000156042.13	G>A	3.0703e-7	-354543	Cerebellum
Chr10:74764074	NUDT13	ENSG00000166321.9	G>A	3.6929e-9	-106143	Hypothalamus
Chr10:74764074	NUDT13	ENSG00000166321.9	G>A	1.5866e-4	-106143	Cortex
Chr10:74764074	NUDT13	ENSG00000166321.9	G>A	1.8918e-5	-106143	Cerebellar_Hemisphere
Chr10:74764074	NUDT13	ENSG00000166321.9	G>A	4.0737e-6	-106143	Caudate_basal_ganglia
Chr10:74764074	NUDT13	ENSG00000166321.9	G>A	1.8681e-6	-106143	Hippocampus
Chr10:74764074	NUDT13	ENSG00000166321.9	G>A	5.7012e-6	-106143	Putamen_basal_ganglia
Chr10:74764074	NUDT13	ENSG00000166321.9	G>A	8.1676e-6	-106143	Nucleus_accumbens_basal_ganglia

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr10	74777745	74778283	E067	13671
chr10	74778388	74778726	E067	14314
chr10	74778858	74778992	E067	14784
chr10	74778388	74778726	E069	14314
chr10	74778858	74778992	E069	14784
chr10	74779019	74779069	E069	14945
chr10	74778388	74778726	E071	14314
chr10	74778858	74778992	E071	14784

rs12573768