rs12591037

Homo sapiens
C>T
TLN2 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0274 (8227/29946,GnomAD)
T=0233 (6797/29118,TOPMED)
T=0324 (1621/5008,1000G)
T=0259 (997/3854,ALSPAC)
T=0255 (946/3708,TWINSUK)
chr15:62656710 (GRCh38.p7) (15q22.2)
AD
GWASdb2
1   publication(s)
See rs on genome
92 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 15NC_000015.10:g.62656710C>T
GRCh37.p13 chr 15NC_000015.9:g.62948909C>T
TLN2 RefSeqGeneNG_033932.1:g.14400C>T

Gene: TLN2, talin 2(plus strand)

Molecule type Change Amino acid[Codon] SO Term
TLN2 transcriptNM_015059.2:c.N/AIntron Variant
TLN2 transcript variant X2XM_005254708.4:c.N/AIntron Variant
TLN2 transcript variant X3XM_005254710.4:c.N/AIntron Variant
TLN2 transcript variant X6XM_005254711.4:c.N/AIntron Variant
TLN2 transcript variant X5XM_005254712.4:c.N/AIntron Variant
TLN2 transcript variant X8XM_005254713.4:c.N/AIntron Variant
TLN2 transcript variant X10XM_005254714.3:c.N/AIntron Variant
TLN2 transcript variant X9XM_005254715.2:c.N/AIntron Variant
TLN2 transcript variant X1XM_006720717.3:c.N/AIntron Variant
TLN2 transcript variant X4XM_017022665.1:c.N/AIntron Variant
TLN2 transcript variant X7XM_017022666.1:c.N/AIntron Variant
TLN2 transcript variant X12XM_017022667.1:c.N/AIntron Variant
TLN2 transcript variant X12XM_017022668.1:c.N/AIntron Variant
TLN2 transcript variant X14XM_017022669.1:c.N/AIntron Variant
TLN2 transcript variant X14XR_001751405.1:n.N/AIntron Variant
TLN2 transcript variant X15XR_001751406.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.834T=0.166
1000GenomesAmericanSub694C=0.660T=0.340
1000GenomesEast AsianSub1008C=0.359T=0.641
1000GenomesEuropeSub1006C=0.736T=0.264
1000GenomesGlobalStudy-wide5008C=0.676T=0.324
1000GenomesSouth AsianSub978C=0.740T=0.260
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.741T=0.259
The Genome Aggregation DatabaseAfricanSub8722C=0.824T=0.176
The Genome Aggregation DatabaseAmericanSub838C=0.660T=0.340
The Genome Aggregation DatabaseEast AsianSub1610C=0.368T=0.632
The Genome Aggregation DatabaseEuropeSub18476C=0.710T=0.289
The Genome Aggregation DatabaseGlobalStudy-wide29946C=0.725T=0.274
The Genome Aggregation DatabaseOtherSub300C=0.880T=0.120
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.766T=0.233
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.745T=0.255
PMID Title Author Journal

P-Value

SNP ID p-value Traits Study
rs125910373.67E-05alcoholismpha002893

eQTL of rs12591037 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs12591037 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr156291055762911290E067-37619
chr156291135662911576E067-37333
chr156291164262912288E067-36621
chr156291692862918062E067-30847
chr156299820362998632E06749294
chr156290262362902697E068-46212
chr156290277362902997E068-45912
chr156290343862903533E068-45376
chr156290362262903675E068-45234
chr156290390162903941E068-44968
chr156291135662911576E068-37333
chr156291164262912288E068-36621
chr156292952662929717E068-19192
chr156292974162929984E068-18925
chr156293156462932051E068-16858
chr156293219462932276E068-16633
chr156293393362934182E068-14727
chr156293675962936837E068-12072
chr156293687962937020E068-11889
chr156293712062937295E068-11614
chr156293742162937893E068-11016
chr156295041962950605E0681510
chr156295071262951073E0681803
chr156299809062998185E06849181
chr156299820362998632E06849294
chr156299867262998811E06849763
chr156291135662911576E069-37333
chr156291164262912288E069-36621
chr156291682562916869E069-32040
chr156291692862918062E069-30847
chr156291827562918388E069-30521
chr156293156462932051E069-16858
chr156293219462932276E069-16633
chr156294019462940306E069-8603
chr156295041962950605E0691510
chr156290262362902697E071-46212
chr156290277362902997E071-45912
chr156291164262912288E071-36621
chr156291692862918062E071-30847
chr156293156462932051E071-16858
chr156293219462932276E071-16633
chr156293712062937295E071-11614
chr156293742162937893E071-11016
chr156299731562997438E07148406
chr156299795262998089E07149043
chr156299809062998185E07149181
chr156299820362998632E07149294
chr156290277362902997E072-45912
chr156291055762911290E072-37619
chr156291135662911576E072-37333
chr156291164262912288E072-36621
chr156291682562916869E072-32040
chr156293156462932051E072-16858
chr156293393362934182E072-14727
chr156293742162937893E072-11016
chr156293949162940164E072-8745
chr156299795262998089E07249043
chr156299809062998185E07249181
chr156299820362998632E07249294
chr156290277362902997E073-45912
chr156291055762911290E073-37619
chr156291135662911576E073-37333
chr156291164262912288E073-36621
chr156291652762916768E073-32141
chr156291682562916869E073-32040
chr156291692862918062E073-30847
chr156291827562918388E073-30521
chr156293156462932051E073-16858
chr156293219462932276E073-16633
chr156293238562932425E073-16484
chr156293248762932537E073-16372
chr156293258362932637E073-16272
chr156289935762899463E074-49446
chr156290262362902697E074-46212
chr156290277362902997E074-45912
chr156291135662911576E074-37333
chr156291164262912288E074-36621
chr156291652762916768E074-32141
chr156291682562916869E074-32040
chr156291692862918062E074-30847
chr156293156462932051E074-16858
chr156293393362934182E074-14727
chr156293675962936837E074-12072
chr156293687962937020E074-11889
chr156293712062937295E074-11614
chr156293742162937893E074-11016
chr156293949162940164E074-8745
chr156294019462940306E074-8603
chr156299731562997438E07448406
chr156299795262998089E07449043
chr156299809062998185E07449181
chr156299820362998632E07449294