rs12656374

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0405 (12132/29946,GnomAD)
T=0481 (14014/29118,TOPMED)
C==0457 (2288/5008,1000G)
T=0310 (1194/3854,ALSPAC)
T=0289 (1072/3708,TWINSUK)
chr5:16346463 (GRCh38.p7) (5p15.1)
CD
GWASdb2
1   publication(s)
See rs on genome
0 Enhancer around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.16346463C>T
GRCh37.p13 chr 5NC_000005.9:g.16346572C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.323T=0.677
1000GenomesAmericanSub694C=0.610T=0.390
1000GenomesEast AsianSub1008C=0.174T=0.826
1000GenomesEuropeSub1006C=0.707T=0.293
1000GenomesGlobalStudy-wide5008C=0.457T=0.543
1000GenomesSouth AsianSub978C=0.570T=0.430
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.690T=0.310
The Genome Aggregation DatabaseAfricanSub8712C=0.368T=0.632
The Genome Aggregation DatabaseAmericanSub838C=0.590T=0.410
The Genome Aggregation DatabaseEast AsianSub1618C=0.193T=0.807
The Genome Aggregation DatabaseEuropeSub18478C=0.737T=0.262
The Genome Aggregation DatabaseGlobalStudy-wide29946C=0.594T=0.405
The Genome Aggregation DatabaseOtherSub300C=0.580T=0.420
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.518T=0.481
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.711T=0.289
PMID Title Author Journal
23958962Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.Gelernter JMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs126563747.8E-05cocaine dependence23958962

eQTL of rs12656374 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs12656374 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.