rs12668955

Homo sapiens
G>A
ADCYAP1R1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0424 (12692/29872,GnomAD)
A=0437 (12739/29118,TOPMED)
A=0453 (2271/5008,1000G)
G==0496 (1912/3854,ALSPAC)
G==0481 (1784/3708,TWINSUK)
chr7:31076553 (GRCh38.p7) (7p14.3)
AD
GWASdb2
1   publication(s)
See rs on genome
303 Enhancers around
48 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.31076553G>A
GRCh37.p13 chr 7NC_000007.13:g.31116168G>A
ADCYAP1R1 RefSeqGeneNG_029869.1:g.29093G>A

Gene: ADCYAP1R1, ADCYAP receptor type I(plus strand)

Molecule type Change Amino acid[Codon] SO Term
ADCYAP1R1 transcript variant 3NM_001118.4:c.N/AIntron Variant
ADCYAP1R1 transcript variant 1NM_001199635.1:c.N/AIntron Variant
ADCYAP1R1 transcript variant 2NM_001199636.1:c.N/AIntron Variant
ADCYAP1R1 transcript variant 4NM_001199637.1:c.N/AIntron Variant
ADCYAP1R1 transcript variant X5XM_005249618.4:c.N/AIntron Variant
ADCYAP1R1 transcript variant X1XM_006715645.2:c.N/AIntron Variant
ADCYAP1R1 transcript variant X2XM_017011736.1:c.N/AIntron Variant
ADCYAP1R1 transcript variant X3XM_017011737.1:c.N/AIntron Variant
ADCYAP1R1 transcript variant X4XM_017011738.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.699A=0.301
1000GenomesAmericanSub694G=0.410A=0.590
1000GenomesEast AsianSub1008G=0.568A=0.432
1000GenomesEuropeSub1006G=0.499A=0.501
1000GenomesGlobalStudy-wide5008G=0.547A=0.453
1000GenomesSouth AsianSub978G=0.470A=0.530
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.496A=0.504
The Genome Aggregation DatabaseAfricanSub8688G=0.683A=0.317
The Genome Aggregation DatabaseAmericanSub838G=0.370A=0.630
The Genome Aggregation DatabaseEast AsianSub1608G=0.620A=0.380
The Genome Aggregation DatabaseEuropeSub18436G=0.530A=0.469
The Genome Aggregation DatabaseGlobalStudy-wide29872G=0.575A=0.424
The Genome Aggregation DatabaseOtherSub302G=0.530A=0.470
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.562A=0.437
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.481A=0.519
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs126689550.000788alcohol dependence20201924

eQTL of rs12668955 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs12668955 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr73106646831066644E067-49524
chr73106670931067342E067-48826
chr73106740431067652E067-48516
chr73106781631067876E067-48292
chr73106793631067995E067-48173
chr73106825331068705E067-47463
chr73106890331068954E067-47214
chr73106896531069024E067-47144
chr73106906131069139E067-47029
chr73107717731077262E067-38906
chr73107732631077376E067-38792
chr73107743431077488E067-38680
chr73107753631077612E067-38556
chr73109553131095607E067-20561
chr73109584131095895E067-20273
chr73109648331096753E067-19415
chr73109697731097072E067-19096
chr73109728831097368E067-18800
chr73109753131097581E067-18587
chr73109893031098983E067-17185
chr73111196331112087E067-4081
chr73111290031113313E067-2855
chr73111340931113559E067-2609
chr73111371031113877E067-2291
chr73111390431113986E067-2182
chr73111399731114070E067-2098
chr73111414031114326E067-1842
chr73111446031114573E067-1595
chr73115468531154865E06738517
chr73106629931066375E068-49793
chr73106646831066644E068-49524
chr73106670931067342E068-48826
chr73106740431067652E068-48516
chr73106781631067876E068-48292
chr73106793631067995E068-48173
chr73106825331068705E068-47463
chr73106890331068954E068-47214
chr73106896531069024E068-47144
chr73106906131069139E068-47029
chr73106933731069571E068-46597
chr73106959931069813E068-46355
chr73108262631083104E068-33064
chr73108315331083511E068-32657
chr73108659231086632E068-29536
chr73108698931087185E068-28983
chr73108735031087414E068-28754
chr73109462431094788E068-21380
chr73109491631095000E068-21168
chr73109502431095317E068-20851
chr73109534531095395E068-20773
chr73109553131095607E068-20561
chr73109584131095895E068-20273
chr73109648331096753E068-19415
chr73109697731097072E068-19096
chr73110611031106177E068-9991
chr73110952931109583E068-6585
chr73111196331112087E068-4081
chr73106646831066644E069-49524
chr73106670931067342E069-48826
chr73106740431067652E069-48516
chr73106890331068954E069-47214
chr73106896531069024E069-47144
chr73106906131069139E069-47029
chr73106933731069571E069-46597
chr73108315331083511E069-32657
chr73109435531094522E069-21646
chr73109462431094788E069-21380
chr73109491631095000E069-21168
chr73109502431095317E069-20851
chr73109534531095395E069-20773
chr73109553131095607E069-20561
chr73109584131095895E069-20273
chr73109697731097072E069-19096
chr73109728831097368E069-18800
chr73109753131097581E069-18587
chr73110226931102319E069-13849
chr73110248431102660E069-13508
chr73110611031106177E069-9991
chr73110642431106478E069-9690
chr73110655931106620E069-9548
chr73110679531106870E069-9298
chr73111043231110487E069-5681
chr73111073731110959E069-5209
chr73111099031111507E069-4661
chr73111196331112087E069-4081
chr73111290031113313E069-2855
chr73111340931113559E069-2609
chr73111371031113877E069-2291
chr73111390431113986E069-2182
chr73111399731114070E069-2098
chr73111414031114326E069-1842
chr73111446031114573E069-1595
chr73111554631115596E069-572
chr73111592231116010E069-158
chr73111752031117626E0691352
chr73111770231117875E0691534
chr73111792731118001E0691759
chr73106629931066375E070-49793
chr73106740431067652E070-48516
chr73106781631067876E070-48292
chr73106793631067995E070-48173
chr73106825331068705E070-47463
chr73106890331068954E070-47214
chr73106896531069024E070-47144
chr73106906131069139E070-47029
chr73106933731069571E070-46597
chr73106959931069813E070-46355
chr73108239031082515E070-33653
chr73108252331082594E070-33574
chr73108262631083104E070-33064
chr73108315331083511E070-32657
chr73108402531084142E070-32026
chr73108421131084396E070-31772
chr73108659231086632E070-29536
chr73106670931067342E071-48826
chr73106740431067652E071-48516
chr73106825331068705E071-47463
chr73106890331068954E071-47214
chr73106896531069024E071-47144
chr73106906131069139E071-47029
chr73106933731069571E071-46597
chr73108315331083511E071-32657
chr73109648331096753E071-19415
chr73109697731097072E071-19096
chr73109788431098016E071-18152
chr73110901031109121E071-7047
chr73110952931109583E071-6585
chr73111011431110213E071-5955
chr73111034431110394E071-5774
chr73111073731110959E071-5209
chr73111399731114070E071-2098
chr73111414031114326E071-1842
chr73111446031114573E071-1595
chr73111820231118357E0712034
chr73106646831066644E072-49524
chr73106670931067342E072-48826
chr73106740431067652E072-48516
chr73106781631067876E072-48292
chr73106793631067995E072-48173
chr73106825331068705E072-47463
chr73106890331068954E072-47214
chr73106896531069024E072-47144
chr73106906131069139E072-47029
chr73106933731069571E072-46597
chr73106959931069813E072-46355
chr73110073431100830E072-15338
chr73110086931101106E072-15062
chr73110248431102660E072-13508
chr73111196331112087E072-4081
chr73111290031113313E072-2855
chr73111340931113559E072-2609
chr73111371031113877E072-2291
chr73111390431113986E072-2182
chr73111399731114070E072-2098
chr73111414031114326E072-1842
chr73111446031114573E072-1595
chr73111700331117107E072835
chr73111722931117279E0721061
chr73111728531117345E0721117
chr73111752031117626E0721352
chr73111770231117875E0721534
chr73106629931066375E073-49793
chr73106646831066644E073-49524
chr73106670931067342E073-48826
chr73106740431067652E073-48516
chr73106781631067876E073-48292
chr73106793631067995E073-48173
chr73106825331068705E073-47463
chr73106890331068954E073-47214
chr73106896531069024E073-47144
chr73106906131069139E073-47029
chr73106933731069571E073-46597
chr73109502431095317E073-20851
chr73109534531095395E073-20773
chr73109553131095607E073-20561
chr73109584131095895E073-20273
chr73109648331096753E073-19415
chr73109697731097072E073-19096
chr73109728831097368E073-18800
chr73109753131097581E073-18587
chr73109762231097721E073-18447
chr73109893031098983E073-17185
chr73109915331099469E073-16699
chr73110226931102319E073-13849
chr73110248431102660E073-13508
chr73110579931105849E073-10319
chr73111196331112087E073-4081
chr73111340931113559E073-2609
chr73111371031113877E073-2291
chr73111390431113986E073-2182
chr73111399731114070E073-2098
chr73111414031114326E073-1842
chr73111446031114573E073-1595
chr73111700331117107E073835
chr73111722931117279E0731061
chr73111728531117345E0731117
chr73111752031117626E0731352
chr73111770231117875E0731534
chr73111792731118001E0731759
chr73111820231118357E0732034
chr73112211931122537E0735951
chr73106670931067342E074-48826
chr73106740431067652E074-48516
chr73106781631067876E074-48292
chr73106793631067995E074-48173
chr73106825331068705E074-47463
chr73106890331068954E074-47214
chr73106896531069024E074-47144
chr73106906131069139E074-47029
chr73106933731069571E074-46597
chr73106959931069813E074-46355
chr73110226931102319E074-13849
chr73110892131108997E074-7171
chr73110901031109121E074-7047
chr73110952931109583E074-6585
chr73111390431113986E074-2182
chr73111399731114070E074-2098
chr73111414031114326E074-1842
chr73111446031114573E074-1595
chr73106629931066375E081-49793
chr73106646831066644E081-49524
chr73106670931067342E081-48826
chr73106740431067652E081-48516
chr73106781631067876E081-48292
chr73106793631067995E081-48173
chr73106825331068705E081-47463
chr73106890331068954E081-47214
chr73106896531069024E081-47144
chr73106906131069139E081-47029
chr73106933731069571E081-46597
chr73106959931069813E081-46355
chr73107002731070159E081-46009
chr73108262631083104E081-33064
chr73109435531094522E081-21646
chr73109462431094788E081-21380
chr73109491631095000E081-21168
chr73109502431095317E081-20851
chr73109534531095395E081-20773
chr73109553131095607E081-20561
chr73109584131095895E081-20273
chr73109648331096753E081-19415
chr73109697731097072E081-19096
chr73109728831097368E081-18800
chr73109893031098983E081-17185
chr73109915331099469E081-16699
chr73109964631100111E081-16057
chr73110065331100709E081-15459
chr73110073431100830E081-15338
chr73110086931101106E081-15062
chr73110139231101451E081-14717
chr73110174931101803E081-14365
chr73110226931102319E081-13849
chr73110248431102660E081-13508
chr73111196331112087E081-4081
chr73111290031113313E081-2855
chr73111340931113559E081-2609
chr73111371031113877E081-2291
chr73111390431113986E081-2182
chr73111399731114070E081-2098
chr73111414031114326E081-1842
chr73115412031154662E08137952
chr73106629931066375E082-49793
chr73106646831066644E082-49524
chr73106670931067342E082-48826
chr73106740431067652E082-48516
chr73106781631067876E082-48292
chr73106793631067995E082-48173
chr73106825331068705E082-47463
chr73106890331068954E082-47214
chr73106896531069024E082-47144
chr73106906131069139E082-47029
chr73106933731069571E082-46597
chr73108262631083104E082-33064
chr73108935731089537E082-26631
chr73108969431089752E082-26416
chr73109056731090627E082-25541
chr73109073831090793E082-25375
chr73109753131097581E082-18587
chr73109762231097721E082-18447
chr73109788431098016E082-18152
chr73109964631100111E082-16057
chr73110086931101106E082-15062
chr73110139231101451E082-14717
chr73110174931101803E082-14365
chr73110226931102319E082-13849
chr73110248431102660E082-13508
chr73110901031109121E082-7047
chr73110952931109583E082-6585
chr73111011431110213E082-5955
chr73111034431110394E082-5774
chr73111043231110487E082-5681
chr73111290031113313E082-2855
chr73111340931113559E082-2609
chr73111371031113877E082-2291
chr73111390431113986E082-2182
chr73111399731114070E082-2098
chr73111414031114326E082-1842
chr73111446031114573E082-1595
chr73111659131116641E082423
chr73111668431116734E082516
chr73111700331117107E082835
chr73111722931117279E0821061
chr73111728531117345E0821117










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr73109134231092737E067-23431
chr73109274831092993E067-23175
chr73109316331093213E067-22955
chr73109384131093981E067-22187
chr73109403831094088E067-22080
chr73109121931091269E068-24899
chr73109134231092737E068-23431
chr73109274831092993E068-23175
chr73109316331093213E068-22955
chr73109384131093981E068-22187
chr73109403831094088E068-22080
chr73109121931091269E069-24899
chr73109134231092737E069-23431
chr73109274831092993E069-23175
chr73109316331093213E069-22955
chr73109384131093981E069-22187
chr73109403831094088E069-22080
chr73109134231092737E070-23431
chr73109274831092993E070-23175
chr73109121931091269E071-24899
chr73109134231092737E071-23431
chr73109274831092993E071-23175
chr73109316331093213E071-22955
chr73109384131093981E071-22187
chr73109403831094088E071-22080
chr73109121931091269E072-24899
chr73109134231092737E072-23431
chr73109274831092993E072-23175
chr73109316331093213E072-22955
chr73109384131093981E072-22187
chr73109403831094088E072-22080
chr73109121931091269E073-24899
chr73109134231092737E073-23431
chr73109274831092993E073-23175
chr73109316331093213E073-22955
chr73109384131093981E073-22187
chr73109403831094088E073-22080
chr73109134231092737E074-23431
chr73109274831092993E074-23175
chr73109316331093213E074-22955
chr73109274831092993E081-23175
chr73109316331093213E081-22955
chr73109121931091269E082-24899
chr73109134231092737E082-23431
chr73109274831092993E082-23175
chr73109316331093213E082-22955
chr73109384131093981E082-22187
chr73109403831094088E082-22080