rs12676336

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0331 (9897/29900,GnomAD)
T=0339 (9878/29118,TOPMED)
T=0382 (1911/5008,1000G)
T=0331 (1274/3854,ALSPAC)
T=0319 (1183/3708,TWINSUK)
chr8:81858773 (GRCh38.p7) (8q21.13)
AD
GWASdb2
1   publication(s)
See rs on genome
89 Enhancers around
39 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.81858773C>T
GRCh37.p13 chr 8NC_000008.10:g.82771008C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.679T=0.321
1000GenomesAmericanSub694C=0.610T=0.390
1000GenomesEast AsianSub1008C=0.403T=0.597
1000GenomesEuropeSub1006C=0.673T=0.327
1000GenomesGlobalStudy-wide5008C=0.618T=0.382
1000GenomesSouth AsianSub978C=0.710T=0.290
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.669T=0.331
The Genome Aggregation DatabaseAfricanSub8680C=0.673T=0.327
The Genome Aggregation DatabaseAmericanSub836C=0.680T=0.320
The Genome Aggregation DatabaseEast AsianSub1614C=0.371T=0.629
The Genome Aggregation DatabaseEuropeSub18468C=0.693T=0.306
The Genome Aggregation DatabaseGlobalStudy-wide29900C=0.669T=0.331
The Genome Aggregation DatabaseOtherSub302C=0.640T=0.360
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.660T=0.339
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.681T=0.319
PMID Title Author Journal
23743675A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Kapoor MHum Genet

P-Value

SNP ID p-value Traits Study
rs126763363.77E-05alcohol consumption23743675

eQTL of rs12676336 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs12676336 in Fetal Brain

Probe ID Position Gene beta p-value
cg17211192chr8:82754475SNX160.06514329975886591.7902e-27
cg27398817chr8:82754497SNX160.03860539417403211.4948e-15
cg23324259chr8:82754387SNX160.01760124910621795.6813e-14

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr88272692182727044E067-43964
chr88272708482727145E067-43863
chr88272739782727713E067-43295
chr88275141582751459E067-19549
chr88275155182751632E067-19376
chr88275169382751743E067-19265
chr88275176982751905E067-19103
chr88275192082751978E067-19030
chr88275205182752101E067-18907
chr88275213682752286E067-18722
chr88275242482752500E067-18508
chr88275252382752586E067-18422
chr88274913582749745E068-21263
chr88275040382750493E068-20515
chr88275055782750622E068-20386
chr88275073382750913E068-20095
chr88275118682751259E068-19749
chr88275141582751459E068-19549
chr88275155182751632E068-19376
chr88275169382751743E068-19265
chr88275242482752500E068-18508
chr88275252382752586E068-18422
chr88275264882752702E068-18306
chr88275205182752101E069-18907
chr88275213682752286E069-18722
chr88275242482752500E069-18508
chr88275252382752586E069-18422
chr88275264882752702E069-18306
chr88273635982736422E070-34586
chr88273760682737656E070-33352
chr88273770482737783E070-33225
chr88274913582749745E070-21263
chr88272692182727044E071-43964
chr88272739782727713E071-43295
chr88275040382750493E071-20515
chr88275055782750622E071-20386
chr88275073382750913E071-20095
chr88275176982751905E071-19103
chr88275192082751978E071-19030
chr88275205182752101E071-18907
chr88275213682752286E071-18722
chr88275242482752500E071-18508
chr88275252382752586E071-18422
chr88275264882752702E071-18306
chr88277068982771569E0710
chr88278429982784817E07113291
chr88272629482726439E072-44569
chr88272692182727044E072-43964
chr88272708482727145E072-43863
chr88272739782727713E072-43295
chr88272739782727713E073-43295
chr88272692182727044E074-43964
chr88275040382750493E074-20515
chr88275055782750622E074-20386
chr88275073382750913E074-20095
chr88275118682751259E074-19749
chr88275141582751459E074-19549
chr88275155182751632E074-19376
chr88275169382751743E074-19265
chr88275176982751905E074-19103
chr88275192082751978E074-19030
chr88275205182752101E074-18907
chr88275213682752286E074-18722
chr88275242482752500E074-18508
chr88275252382752586E074-18422
chr88275264882752702E074-18306
chr88278429982784817E07413291
chr88274894182748991E081-22017
chr88275118682751259E081-19749
chr88275141582751459E081-19549
chr88275155182751632E081-19376
chr88275169382751743E081-19265
chr88275176982751905E081-19103
chr88275192082751978E081-19030
chr88275205182752101E081-18907
chr88275213682752286E081-18722
chr88275242482752500E081-18508
chr88275252382752586E081-18422
chr88275264882752702E081-18306
chr88274913582749745E082-21263
chr88274982582749873E082-21135
chr88275155182751632E082-19376
chr88275169382751743E082-19265
chr88275176982751905E082-19103
chr88275192082751978E082-19030
chr88275205182752101E082-18907
chr88275213682752286E082-18722
chr88275242482752500E082-18508
chr88275252382752586E082-18422










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr88275290282753069E067-17939
chr88275314082753307E067-17701
chr88275349982753591E067-17417
chr88275360282754599E067-16409
chr88275349982753591E068-17417
chr88275360282754599E068-16409
chr88275461982755486E068-15522
chr88275290282753069E069-17939
chr88275314082753307E069-17701
chr88275349982753591E069-17417
chr88275360282754599E069-16409
chr88275290282753069E070-17939
chr88275314082753307E070-17701
chr88275349982753591E070-17417
chr88275360282754599E070-16409
chr88275290282753069E071-17939
chr88275314082753307E071-17701
chr88275349982753591E071-17417
chr88275360282754599E071-16409
chr88275461982755486E071-15522
chr88275290282753069E072-17939
chr88275314082753307E072-17701
chr88275349982753591E072-17417
chr88275360282754599E072-16409
chr88275290282753069E073-17939
chr88275314082753307E073-17701
chr88275349982753591E073-17417
chr88275360282754599E073-16409
chr88275461982755486E073-15522
chr88275314082753307E074-17701
chr88275349982753591E074-17417
chr88275360282754599E074-16409
chr88275461982755486E074-15522
chr88275360282754599E081-16409
chr88275290282753069E082-17939
chr88275314082753307E082-17701
chr88275349982753591E082-17417
chr88275360282754599E082-16409
chr88275461982755486E082-15522