rs12676437

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0072 (2158/29858,GnomAD)
C=0058 (1688/29118,TOPMED)
C=0117 (588/5008,1000G)
C=0078 (299/3854,ALSPAC)
C=0079 (292/3708,TWINSUK)
chr8:2886750 (GRCh38.p7) (8p23.2)
AD
GWASdb2
1   publication(s)
See rs on genome
21 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.2886750T>C
GRCh37.p13 chr 8NC_000008.10:g.2744272T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.995C=0.005
1000GenomesAmericanSub694T=0.890C=0.110
1000GenomesEast AsianSub1008T=0.705C=0.295
1000GenomesEuropeSub1006T=0.915C=0.085
1000GenomesGlobalStudy-wide5008T=0.883C=0.117
1000GenomesSouth AsianSub978T=0.870C=0.130
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.922C=0.078
The Genome Aggregation DatabaseAfricanSub8706T=0.984C=0.016
The Genome Aggregation DatabaseAmericanSub838T=0.880C=0.120
The Genome Aggregation DatabaseEast AsianSub1614T=0.673C=0.327
The Genome Aggregation DatabaseEuropeSub18398T=0.925C=0.074
The Genome Aggregation DatabaseGlobalStudy-wide29858T=0.927C=0.072
The Genome Aggregation DatabaseOtherSub302T=0.930C=0.070
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.942C=0.058
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.921C=0.079
PMID Title Author Journal
23743675A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Kapoor MHum Genet

P-Value

SNP ID p-value Traits Study
rs126764372E-05alcohol consumption23743675

eQTL of rs12676437 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs12676437 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr827680592768146E07023787
chr827721322772253E07327860
chr827329582733044E081-11228
chr827331402733190E081-11082
chr827338302734178E081-10094
chr827342912734399E081-9873
chr827344262734552E081-9720
chr827345592734631E081-9641
chr827347922735143E081-9129
chr827352742735314E081-8958
chr827354172735610E081-8662
chr827365032736642E081-7630
chr827428372743010E081-1262
chr827430402743997E081-275
chr827471922747310E0812920
chr827475482747817E0813276
chr827338302734178E082-10094
chr827342912734399E082-9873
chr827344262734552E082-9720
chr827345592734631E082-9641
chr827430402743997E082-275