rs12677246

Homo sapiens
C>G
TG : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0111 (3332/29948,GnomAD)
G=0105 (3069/29118,TOPMED)
G=0197 (987/5008,1000G)
G=0066 (255/3854,ALSPAC)
G=0067 (247/3708,TWINSUK)
chr8:132955150 (GRCh38.p7) (8q24.22)
AD
GWASdb2
1   publication(s)
See rs on genome
103 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.132955150C>G
GRCh37.p13 chr 8NC_000008.10:g.133967395C>G
TG RefSeqGeneNG_015832.1:g.93191C>G

Gene: TG, thyroglobulin(plus strand)

Molecule type Change Amino acid[Codon] SO Term
TG transcriptNM_003235.4:c.N/AIntron Variant
TG transcript variant X5XM_005251038.4:c.N/AIntron Variant
TG transcript variant X9XM_005251040.4:c.N/AIntron Variant
TG transcript variant X11XM_005251042.4:c.N/AIntron Variant
TG transcript variant X1XM_006716622.3:c.N/AIntron Variant
TG transcript variant X2XM_017013793.1:c.N/AIntron Variant
TG transcript variant X3XM_017013794.1:c.N/AIntron Variant
TG transcript variant X4XM_017013795.1:c.N/AIntron Variant
TG transcript variant X6XM_017013796.1:c.N/AIntron Variant
TG transcript variant X7XM_017013797.1:c.N/AIntron Variant
TG transcript variant X8XM_017013798.1:c.N/AIntron Variant
TG transcript variant X10XM_017013799.1:c.N/AIntron Variant
TG transcript variant X12XM_017013800.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.856G=0.144
1000GenomesAmericanSub694C=0.860G=0.140
1000GenomesEast AsianSub1008C=0.542G=0.458
1000GenomesEuropeSub1006C=0.926G=0.074
1000GenomesGlobalStudy-wide5008C=0.803G=0.197
1000GenomesSouth AsianSub978C=0.840G=0.160
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.934G=0.066
The Genome Aggregation DatabaseAfricanSub8706C=0.877G=0.123
The Genome Aggregation DatabaseAmericanSub838C=0.870G=0.130
The Genome Aggregation DatabaseEast AsianSub1620C=0.586G=0.414
The Genome Aggregation DatabaseEuropeSub18484C=0.921G=0.078
The Genome Aggregation DatabaseGlobalStudy-wide29948C=0.888G=0.111
The Genome Aggregation DatabaseOtherSub300C=0.880G=0.120
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.894G=0.105
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.933G=0.067
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs126772460.000887alcohol dependence21314694

eQTL of rs12677246 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs12677246 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr8133919722133919836E067-47559
chr8133950404133950477E067-16918
chr8133950567133950627E067-16768
chr8133950644133950694E067-16701
chr8133950798133950852E067-16543
chr8134003564134004493E06736169
chr8134012165134012225E06744770
chr8134012310134012688E06744915
chr8134012725134012837E06745330
chr8134012907134013122E06745512
chr8134013225134013371E06745830
chr8133918369133918437E068-48958
chr8133918447133918512E068-48883
chr8133918515133918625E068-48770
chr8133918927133919447E068-47948
chr8133990509133990637E06823114
chr8133990687133991938E06823292
chr8134012165134012225E06844770
chr8134012310134012688E06844915
chr8134012725134012837E06845330
chr8134012907134013122E06845512
chr8133918447133918512E069-48883
chr8133919722133919836E069-47559
chr8134006780134006911E06939385
chr8134007079134007159E06939684
chr8134007251134007392E06939856
chr8134012165134012225E06944770
chr8134012310134012688E06944915
chr8134012725134012837E06945330
chr8134012907134013122E06945512
chr8134015104134015184E06947709
chr8133990687133991938E07123292
chr8134003564134004493E07136169
chr8134012165134012225E07144770
chr8134012310134012688E07144915
chr8134012725134012837E07145330
chr8134012907134013122E07145512
chr8134012165134012225E07244770
chr8134012310134012688E07244915
chr8134012725134012837E07245330
chr8134012907134013122E07245512
chr8133918447133918512E073-48883
chr8133919722133919836E073-47559
chr8133920226133920407E073-46988
chr8133949055133949308E073-18087
chr8133950216133950344E073-17051
chr8133950404133950477E073-16918
chr8133950567133950627E073-16768
chr8134012310134012688E07344915
chr8134012725134012837E07345330
chr8134012907134013122E07345512
chr8134013225134013371E07345830
chr8134013416134013489E07346021
chr8133919722133919836E074-47559
chr8133966678133967113E074-282
chr8133967214133967476E0740
chr8133967525133967620E074130
chr8133967739133967848E074344
chr8134012165134012225E07444770
chr8134012310134012688E07444915
chr8134012725134012837E07445330
chr8134012907134013122E07445512
chr8134013225134013371E07445830
chr8134013416134013489E07446021
chr8134013618134014056E07446223
chr8133937738133937927E081-29468
chr8133938053133938329E081-29066
chr8133938420133938524E081-28871
chr8133938566133938616E081-28779
chr8133938638133938705E081-28690
chr8133938870133938920E081-28475
chr8133938976133939044E081-28351
chr8133939093133939269E081-28126
chr8133939364133939551E081-27844
chr8133939671133939746E081-27649
chr8133939797133940397E081-26998
chr8133940508133940652E081-26743
chr8133975846133975938E0818451
chr8133976004133976382E0818609
chr8133976434133976580E0819039
chr8133976591133976864E0819196
chr8133993609133993979E08126214
chr8133993992133994066E08126597
chr8133994151133994402E08126756
chr8133997873133998078E08130478
chr8133998160133998385E08130765
chr8133999334133999709E08131939
chr8133999800133999850E08132405
chr8133999966134000404E08132571
chr8134000528134000707E08133133
chr8134001270134001383E08133875
chr8134015582134015626E08148187
chr8133939364133939551E082-27844
chr8133975846133975938E0828451
chr8133976004133976382E0828609
chr8133976434133976580E0829039
chr8133976591133976864E0829196
chr8133997380133997830E08229985
chr8133997873133998078E08230478
chr8133999334133999709E08231939
chr8134001270134001383E08233875
chr8134001717134002121E08234322
chr8134002463134002513E08235068