rs12677935

Homo sapiens
G>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0072 (2156/29894,GnomAD)
C=0058 (1688/29118,TOPMED)
C=0078 (300/3854,ALSPAC)
C=0079 (293/3708,TWINSUK)
chr8:2886993 (GRCh38.p7) (8p23.2)
AD
GWASdb2
1   publication(s)
See rs on genome
21 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.2886993G>C
GRCh37.p13 chr 8NC_000008.10:g.2744515G>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.922C=0.078
The Genome Aggregation DatabaseAfricanSub8712G=0.984C=0.016
The Genome Aggregation DatabaseAmericanSub832G=0.880C=0.120
The Genome Aggregation DatabaseEast AsianSub1618G=0.675C=0.325
The Genome Aggregation DatabaseEuropeSub18430G=0.925C=0.074
The Genome Aggregation DatabaseGlobalStudy-wide29894G=0.927C=0.072
The Genome Aggregation DatabaseOtherSub302G=0.930C=0.070
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.942C=0.058
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.921C=0.079
PMID Title Author Journal
23743675A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Kapoor MHum Genet

P-Value

SNP ID p-value Traits Study
rs126779352.03E-05alcohol consumption23743675

eQTL of rs12677935 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs12677935 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr827680592768146E07023544
chr827721322772253E07327617
chr827329582733044E081-11471
chr827331402733190E081-11325
chr827338302734178E081-10337
chr827342912734399E081-10116
chr827344262734552E081-9963
chr827345592734631E081-9884
chr827347922735143E081-9372
chr827352742735314E081-9201
chr827354172735610E081-8905
chr827365032736642E081-7873
chr827428372743010E081-1505
chr827430402743997E081-518
chr827471922747310E0812677
chr827475482747817E0813033
chr827338302734178E082-10337
chr827342912734399E082-10116
chr827344262734552E082-9963
chr827345592734631E082-9884
chr827430402743997E082-518