rs12680810

Homo sapiens
T>A
None
Check p-value
SNV (Single Nucleotide Variation)
A=0349 (10363/29690,GnomAD)
A=0346 (10084/29118,TOPMED)
A=0346 (1733/5008,1000G)
A=0416 (1604/3854,ALSPAC)
A=0408 (1512/3708,TWINSUK)
chr8:77231908 (GRCh38.p7) (8q21.13)
ND
GWASCatalog
1   publication(s)
See rs on genome
1 Enhancer around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.77231908T>A
GRCh37.p13 chr 8NC_000008.10:g.78144144T>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.781A=0.219
1000GenomesAmericanSub694T=0.700A=0.300
1000GenomesEast AsianSub1008T=0.616A=0.384
1000GenomesEuropeSub1006T=0.589A=0.411
1000GenomesGlobalStudy-wide5008T=0.654A=0.346
1000GenomesSouth AsianSub978T=0.560A=0.440
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.584A=0.416
The Genome Aggregation DatabaseAfricanSub8682T=0.770A=0.230
The Genome Aggregation DatabaseAmericanSub822T=0.670A=0.330
The Genome Aggregation DatabaseEast AsianSub1596T=0.605A=0.395
The Genome Aggregation DatabaseEuropeSub18288T=0.599A=0.400
The Genome Aggregation DatabaseGlobalStudy-wide29690T=0.651A=0.349
The Genome Aggregation DatabaseOtherSub302T=0.540A=0.460
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.653A=0.346
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.592A=0.408
PMID Title Author Journal
28440896Genome-wide meta-analysis identifies a novel susceptibility signal at CACNA2D3 for nicotine dependence.Yin XAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs126808101E-06nicotine dependence28440896

eQTL of rs12680810 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs12680810 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr87817174578171884E07027601