rs1269068

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
C==0473 (14139/29866,GnomAD)
C==0405 (11801/29118,TOPMED)
C==0345 (1727/5008,1000G)
T=0362 (1395/3854,ALSPAC)
T=0353 (1310/3708,TWINSUK)
chr14:65300615 (GRCh38.p7) (14q23.3)
AD
GWASdb2
1   publication(s)
See rs on genome
149 Enhancers around
8 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 14NC_000014.9:g.65300615C>T
GRCh37.p13 chr 14NC_000014.8:g.65767333C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.118T=0.882
1000GenomesAmericanSub694C=0.510T=0.490
1000GenomesEast AsianSub1008C=0.242T=0.758
1000GenomesEuropeSub1006C=0.559T=0.441
1000GenomesGlobalStudy-wide5008C=0.345T=0.655
1000GenomesSouth AsianSub978C=0.420T=0.580
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.638T=0.362
The Genome Aggregation DatabaseAfricanSub8698C=0.188T=0.812
The Genome Aggregation DatabaseAmericanSub838C=0.550T=0.450
The Genome Aggregation DatabaseEast AsianSub1618C=0.240T=0.760
The Genome Aggregation DatabaseEuropeSub18416C=0.624T=0.375
The Genome Aggregation DatabaseGlobalStudy-wide29866C=0.473T=0.526
The Genome Aggregation DatabaseOtherSub296C=0.510T=0.490
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.405T=0.594
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.647T=0.353
PMID Title Author Journal
19581569Genome-wide association study of alcohol dependence.Treutlein JArch Gen Psychiatry

P-Value

SNP ID p-value Traits Study
rs12690684.05E-05alcohol dependence19581569

eQTL of rs1269068 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1269068 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr146572160565723396E067-43937
chr146574188165741931E067-25402
chr146574230565742353E067-24980
chr146574236065742410E067-24923
chr146574355365744333E067-23000
chr146575001565750060E067-17273
chr146575010765750256E067-17077
chr146575101765751321E067-16012
chr146575169965752009E067-15324
chr146576863465769921E0671301
chr146576992265770071E0672589
chr146577017465770586E0672841
chr146577071665770903E0673383
chr146577091565771062E0673582
chr146577107165771313E0673738
chr146581482565815286E06747492
chr146581532165815369E06747988
chr146572090665720956E068-46377
chr146574230565742353E068-24980
chr146574319065743240E068-24093
chr146574355365744333E068-23000
chr146574437565744595E068-22738
chr146574466565745236E068-22097
chr146575001565750060E068-17273
chr146575010765750256E068-17077
chr146575101765751321E068-16012
chr146575169965752009E068-15324
chr146576863465769921E0681301
chr146576992265770071E0682589
chr146577071665770903E0683383
chr146581324565813455E06845912
chr146572160565723396E069-43937
chr146573466365735022E069-32311
chr146574077365740876E069-26457
chr146574102565741147E069-26186
chr146574188165741931E069-25402
chr146574230565742353E069-24980
chr146574236065742410E069-24923
chr146574319065743240E069-24093
chr146574355365744333E069-23000
chr146575010765750256E069-17077
chr146575101765751321E069-16012
chr146575169965752009E069-15324
chr146575232965752419E069-14914
chr146575320365753778E069-13555
chr146576863465769921E0691301
chr146576992265770071E0692589
chr146577017465770586E0692841
chr146577071665770903E0693383
chr146577091565771062E0693582
chr146577107165771313E0693738
chr146578387365783984E06916540
chr146578400165784051E06916668
chr146578408865784152E06916755
chr146578418265784254E06916849
chr146578493165785016E06917598
chr146579642765796624E06929094
chr146581346365814129E06946130
chr146575001565750060E070-17273
chr146575010765750256E070-17077
chr146576992265770071E0702589
chr146572038765720497E071-46836
chr146572055465720640E071-46693
chr146572090665720956E071-46377
chr146572160565723396E071-43937
chr146573466365735022E071-32311
chr146574236065742410E071-24923
chr146574319065743240E071-24093
chr146574355365744333E071-23000
chr146574437565744595E071-22738
chr146574466565745236E071-22097
chr146574555665745600E071-21733
chr146574615165746261E071-21072
chr146574639765746447E071-20886
chr146574656165746641E071-20692
chr146574665965746949E071-20384
chr146574774265747802E071-19531
chr146574780865747871E071-19462
chr146574790465747960E071-19373
chr146574844065748499E071-18834
chr146575001565750060E071-17273
chr146575010765750256E071-17077
chr146575101765751321E071-16012
chr146575169965752009E071-15324
chr146575320365753778E071-13555
chr146575379465754904E071-12429
chr146575492565755020E071-12313
chr146576863465769921E0711301
chr146576992265770071E0712589
chr146577017465770586E0712841
chr146577071665770903E0713383
chr146577091565771062E0713582
chr146577107165771313E0713738
chr146581482565815286E07147492
chr146581532165815369E07147988
chr146572160565723396E072-43937
chr146573466365735022E072-32311
chr146573532265735381E072-31952
chr146573547665735692E072-31641
chr146574355365744333E072-23000
chr146574437565744595E072-22738
chr146574466565745236E072-22097
chr146574555665745600E072-21733
chr146574615165746261E072-21072
chr146574639765746447E072-20886
chr146574656165746641E072-20692
chr146574665965746949E072-20384
chr146575001565750060E072-17273
chr146575010765750256E072-17077
chr146575101765751321E072-16012
chr146575169965752009E072-15324
chr146575320365753778E072-13555
chr146576863465769921E0721301
chr146576992265770071E0722589
chr146577017465770586E0722841
chr146577071665770903E0723383
chr146577091565771062E0723582
chr146577107165771313E0723738
chr146574355365744333E073-23000
chr146575001565750060E073-17273
chr146575010765750256E073-17077
chr146572038765720497E074-46836
chr146572055465720640E074-46693
chr146572090665720956E074-46377
chr146572160565723396E074-43937
chr146574230565742353E074-24980
chr146574236065742410E074-24923
chr146574319065743240E074-24093
chr146574355365744333E074-23000
chr146574437565744595E074-22738
chr146574466565745236E074-22097
chr146575101765751321E074-16012
chr146575169965752009E074-15324
chr146575320365753778E074-13555
chr146575379465754904E074-12429
chr146575824865758298E074-9035
chr146575840265758532E074-8801
chr146575859965758717E074-8616
chr146575872065759017E074-8316
chr146576863465769921E0741301
chr146576992265770071E0742589
chr146577017465770586E0742841
chr146577071665770903E0743383
chr146577091565771062E0743582
chr146577107165771313E0743738
chr146577166965771925E0744336
chr146581324565813455E07445912
chr146581346365814129E07446130
chr146581416665814223E07446833








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr146573340565733463E068-33870
chr146573355465733703E068-33630
chr146573340565733463E069-33870
chr146573355465733703E069-33630
chr146573340565733463E073-33870
chr146573355465733703E073-33630
chr146573340565733463E074-33870
chr146573355465733703E074-33630