SNP Detail Info-rs12776254

Organism: Homo sapiens

Alleles: A>G

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G=0143 (4287/29958,GnomAD)
G=0127 (3709/29118,TOPMED)
G=0114 (570/5008,1000G)
G=0167 (645/3854,ALSPAC)
G=0177 (656/3708,TWINSUK)

Position: chr10:2112668 (GRCh38.p7) (10p15.3)

Phenotype: AD

Dataset:

GWASdb2

Publications: 2 publication(s)

Genomic View: See rs on genome

Enhancer: 14 Enhancers around

Promoter: 0 Promoter around

Sequence Name	Change(s)
GRCh38.p7 chr 10	NC_000010.11:g.2112668A>G
GRCh37.p13 chr 10	NC_000010.10:g.2154862A>G

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	A=0.924	G=0.076
1000Genomes	American	Sub	694	A=0.840	G=0.160
1000Genomes	East Asian	Sub	1008	A=0.893	G=0.107
1000Genomes	Europe	Sub	1006	A=0.836	G=0.164
1000Genomes	Global	Study-wide	5008	A=0.886	G=0.114
1000Genomes	South Asian	Sub	978	A=0.910	G=0.090
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.833	G=0.167
The Genome Aggregation Database	African	Sub	8726	A=0.907	G=0.093
The Genome Aggregation Database	American	Sub	834	A=0.840	G=0.160
The Genome Aggregation Database	East Asian	Sub	1620	A=0.883	G=0.117
The Genome Aggregation Database	Europe	Sub	18476	A=0.831	G=0.168
The Genome Aggregation Database	Global	Study-wide	29958	A=0.856	G=0.143
The Genome Aggregation Database	Other	Sub	302	A=0.880	G=0.120
Trans-Omics for Precision Medicine	Global	Study-wide	29118	A=0.872	G=0.127
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.823	G=0.177

PMID	Title	Author	Journal
21703634	A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.	Wang KS	J Psychiatr Res
20202923	A genome-wide association study of alcohol dependence.	Bierut LJ	Proc Natl Acad Sci U S A

SNP ID	p-value	Traits	Study
rs12776254	0.00000182	alcohol dependence	20202923
rs12776254	0.0000681	alcohol dependence	21703634

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr10	2112674	2112811	E070	-42051
chr10	2112837	2112969	E070	-41893
chr10	2131572	2131642	E070	-23220
chr10	2131685	2131870	E070	-22992
chr10	2164227	2164406	E070	9365
chr10	2164572	2165301	E070	9710
chr10	2170361	2170562	E081	15499
chr10	2170819	2170869	E081	15957
chr10	2117409	2117491	E082	-37371
chr10	2117519	2117632	E082	-37230
chr10	2117675	2117729	E082	-37133
chr10	2117735	2117828	E082	-37034
chr10	2170819	2170869	E082	15957
chr10	2170911	2171103	E082	16049

rs12776254