rs12805661

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0242 (7248/29942,GnomAD)
T=0226 (6585/29118,TOPMED)
T=0350 (1752/5008,1000G)
T=0286 (1102/3854,ALSPAC)
T=0272 (1009/3708,TWINSUK)
chr11:2999510 (GRCh38.p7) (11p15.4)
AD
GWASdb2
1   publication(s)
See rs on genome
337 Enhancers around
19 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.2999510C>T
GRCh37.p13 chr 11NC_000011.9:g.3020740C>T
GRCh38.p7 chr 11 alt locus HSCHR11_1_CTG7NT_187585.1:g.230572T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.970T=0.030
1000GenomesAmericanSub694C=0.500T=0.500
1000GenomesEast AsianSub1008C=0.340T=0.660
1000GenomesEuropeSub1006C=0.709T=0.291
1000GenomesGlobalStudy-wide5008C=0.650T=0.350
1000GenomesSouth AsianSub978C=0.580T=0.420
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.714T=0.286
The Genome Aggregation DatabaseAfricanSub8718C=0.927T=0.073
The Genome Aggregation DatabaseAmericanSub838C=0.480T=0.520
The Genome Aggregation DatabaseEast AsianSub1616C=0.368T=0.632
The Genome Aggregation DatabaseEuropeSub18470C=0.726T=0.273
The Genome Aggregation DatabaseGlobalStudy-wide29942C=0.757T=0.242
The Genome Aggregation DatabaseOtherSub300C=0.660T=0.340
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.773T=0.226
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.728T=0.272
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs128056610.00015alcohol dependence(early age of onset)20201924
rs128056610.00068alcohol dependence20201924

eQTL of rs12805661 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs12805661 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr1130034183003948E067-16792
chr1130044323004472E067-16268
chr1130044753004606E067-16134
chr1130083713008482E067-12258
chr1130085403008614E067-12126
chr1130090683009383E067-11357
chr1130197123019867E067-873
chr1130199653020015E067-725
chr1130206083020715E067-25
chr1130207813020831E06741
chr1130209853021035E067245
chr1130213433023046E067603
chr1130231133023234E0672373
chr1130232433023293E0672503
chr1130233113023375E0672571
chr1130235313023614E0672791
chr1130238543023904E0673114
chr1130242343024284E0673494
chr1130245403024669E0673800
chr1130246863024736E0673946
chr1130250523025109E0674312
chr1130251573025416E0674417
chr1130256733025723E0674933
chr1130420223042072E06721282
chr1130422623042740E06721522
chr1130511793051219E06730439
chr1130513803051434E06730640
chr1130515143051804E06730774
chr1130564463056535E06735706
chr1130566183056925E06735878
chr1130576093058080E06736869
chr1130629663063295E06742226
chr1130633203063649E06742580
chr1130637243064341E06742984
chr1130643523064467E06743612
chr1130644723064738E06743732
chr1130647903065068E06744050
chr1130651893065537E06744449
chr1130669483067262E06746208
chr1130675333067642E06746793
chr1130701433070222E06749403
chr1130705253070657E06749785
chr1130034183003948E068-16792
chr1130044323004472E068-16268
chr1130044753004606E068-16134
chr1130046313004681E068-16059
chr1130047883004842E068-15898
chr1130206083020715E068-25
chr1130207813020831E06841
chr1130209853021035E068245
chr1130231133023234E0682373
chr1130232433023293E0682503
chr1130233113023375E0682571
chr1130235313023614E0682791
chr1130238543023904E0683114
chr1130242343024284E0683494
chr1130245403024669E0683800
chr1130246863024736E0683946
chr1130250523025109E0684312
chr1130251573025416E0684417
chr1130256733025723E0684933
chr1130259883026062E0685248
chr1130271013027156E0686361
chr1130420223042072E06821282
chr1130422623042740E06821522
chr1130429893043063E06822249
chr1130432503043327E06822510
chr1130434703044622E06822730
chr1130583013059394E06837561
chr1130629663063295E06842226
chr1130633203063649E06842580
chr1130637243064341E06842984
chr1130643523064467E06843612
chr1130644723064738E06843732
chr1130647903065068E06844050
chr1130651893065537E06844449
chr1130705253070657E06849785
chr1129968922997117E069-23623
chr1129971372997477E069-23263
chr1129975392997788E069-22952
chr1129978042998183E069-22557
chr1130034183003948E069-16792
chr1130044323004472E069-16268
chr1130044753004606E069-16134
chr1130046313004681E069-16059
chr1130047883004842E069-15898
chr1130083713008482E069-12258
chr1130206083020715E069-25
chr1130207813020831E06941
chr1130209853021035E069245
chr1130231133023234E0692373
chr1130232433023293E0692503
chr1130233113023375E0692571
chr1130235313023614E0692791
chr1130238543023904E0693114
chr1130242343024284E0693494
chr1130245403024669E0693800
chr1130246863024736E0693946
chr1130250523025109E0694312
chr1130251573025416E0694417
chr1130310653031130E06910325
chr1130312013031261E06910461
chr1130418503041909E06921110
chr1130420223042072E06921282
chr1130422623042740E06921522
chr1130434703044622E06922730
chr1130446673044748E06923927
chr1130501743050295E06929434
chr1130503373050432E06929597
chr1130505563050763E06929816
chr1130511793051219E06930439
chr1130513803051434E06930640
chr1130515143051804E06930774
chr1130583013059394E06937561
chr1130629663063295E06942226
chr1130633203063649E06942580
chr1130637243064341E06942984
chr1130643523064467E06943612
chr1130644723064738E06943732
chr1130647903065068E06944050
chr1130651893065537E06944449
chr1130690883069175E06948348
chr1130696973069741E06948957
chr1130701433070222E06949403
chr1130033003003360E070-17380
chr1130034183003948E070-16792
chr1130705253070657E07049785
chr1130034183003948E071-16792
chr1130044323004472E071-16268
chr1130044753004606E071-16134
chr1130046313004681E071-16059
chr1130047883004842E071-15898
chr1130049403004995E071-15745
chr1130083713008482E071-12258
chr1130085403008614E071-12126
chr1130090683009383E071-11357
chr1130206083020715E071-25
chr1130207813020831E07141
chr1130209853021035E071245
chr1130231133023234E0712373
chr1130232433023293E0712503
chr1130233113023375E0712571
chr1130235313023614E0712791
chr1130238543023904E0713114
chr1130242343024284E0713494
chr1130245403024669E0713800
chr1130246863024736E0713946
chr1130250523025109E0714312
chr1130251573025416E0714417
chr1130256733025723E0714933
chr1130309213030975E07110181
chr1130310653031130E07110325
chr1130312013031261E07110461
chr1130346583034866E07113918
chr1130350633035174E07114323
chr1130365123036578E07115772
chr1130366553036836E07115915
chr1130418503041909E07121110
chr1130420223042072E07121282
chr1130422623042740E07121522
chr1130503373050432E07129597
chr1130505563050763E07129816
chr1130511793051219E07130439
chr1130513803051434E07130640
chr1130515143051804E07130774
chr1130518653052209E07131125
chr1130576093058080E07136869
chr1130583013059394E07137561
chr1130629663063295E07142226
chr1130633203063649E07142580
chr1130637243064341E07142984
chr1130643523064467E07143612
chr1130644723064738E07143732
chr1130647903065068E07144050
chr1130651893065537E07144449
chr1130659703066020E07145230
chr1130675333067642E07146793
chr1130695763069626E07148836
chr1130696973069741E07148957
chr1130701433070222E07149403
chr1129860272986242E072-34498
chr1129863492986409E072-34331
chr1129968922997117E072-23623
chr1129971372997477E072-23263
chr1129975392997788E072-22952
chr1129978042998183E072-22557
chr1130024623002554E072-18186
chr1130026943002744E072-17996
chr1130030563003286E072-17454
chr1130033003003360E072-17380
chr1130034183003948E072-16792
chr1130044323004472E072-16268
chr1130044753004606E072-16134
chr1130046313004681E072-16059
chr1130047883004842E072-15898
chr1130049403004995E072-15745
chr1130090683009383E072-11357
chr1130206083020715E072-25
chr1130207813020831E07241
chr1130209853021035E072245
chr1130213433023046E072603
chr1130231133023234E0722373
chr1130232433023293E0722503
chr1130233113023375E0722571
chr1130235313023614E0722791
chr1130238543023904E0723114
chr1130242343024284E0723494
chr1130245403024669E0723800
chr1130246863024736E0723946
chr1130250523025109E0724312
chr1130251573025416E0724417
chr1130256733025723E0724933
chr1130259883026062E0725248
chr1130309213030975E07210181
chr1130310653031130E07210325
chr1130312013031261E07210461
chr1130317513031801E07211011
chr1130319633032013E07211223
chr1130321823032490E07211442
chr1130366553036836E07215915
chr1130368513036917E07216111
chr1130418503041909E07221110
chr1130420223042072E07221282
chr1130422623042740E07221522
chr1130511793051219E07230439
chr1130513803051434E07230640
chr1130515143051804E07230774
chr1130576093058080E07236869
chr1130583013059394E07237561
chr1130629663063295E07242226
chr1130633203063649E07242580
chr1130637243064341E07242984
chr1130643523064467E07243612
chr1130644723064738E07243732
chr1130647903065068E07244050
chr1130651893065537E07244449
chr1130659703066020E07245230
chr1130660283066093E07245288
chr1130661263066207E07245386
chr1130669483067262E07246208
chr1130675333067642E07246793
chr1130701433070222E07249403
chr1129975392997788E073-22952
chr1129978042998183E073-22557
chr1130030563003286E073-17454
chr1130033003003360E073-17380
chr1130034183003948E073-16792
chr1130081743008263E073-12477
chr1130083713008482E073-12258
chr1130085403008614E073-12126
chr1130090683009383E073-11357
chr1130206083020715E073-25
chr1130207813020831E07341
chr1130209853021035E073245
chr1130213433023046E073603
chr1130231133023234E0732373
chr1130232433023293E0732503
chr1130233113023375E0732571
chr1130235313023614E0732791
chr1130238543023904E0733114
chr1130242343024284E0733494
chr1130251573025416E0734417
chr1130256733025723E0734933
chr1130309213030975E07310181
chr1130310653031130E07310325
chr1130312013031261E07310461
chr1130420223042072E07321282
chr1130422623042740E07321522
chr1130511793051219E07330439
chr1130513803051434E07330640
chr1130515143051804E07330774
chr1130576093058080E07336869
chr1130583013059394E07337561
chr1130629663063295E07342226
chr1130633203063649E07342580
chr1130637243064341E07342984
chr1130643523064467E07343612
chr1130644723064738E07343732
chr1130647903065068E07344050
chr1130651893065537E07344449
chr1130701433070222E07349403
chr1129999033000044E074-20696
chr1130030563003286E074-17454
chr1130033003003360E074-17380
chr1130034183003948E074-16792
chr1130044323004472E074-16268
chr1130044753004606E074-16134
chr1130046313004681E074-16059
chr1130047883004842E074-15898
chr1130049403004995E074-15745
chr1130081743008263E074-12477
chr1130083713008482E074-12258
chr1130085403008614E074-12126
chr1130188263018892E074-1848
chr1130190553019389E074-1351
chr1130206083020715E074-25
chr1130207813020831E07441
chr1130209853021035E074245
chr1130213433023046E074603
chr1130231133023234E0742373
chr1130235313023614E0742791
chr1130238543023904E0743114
chr1130242343024284E0743494
chr1130245403024669E0743800
chr1130246863024736E0743946
chr1130250523025109E0744312
chr1130251573025416E0744417
chr1130256733025723E0744933
chr1130266363026866E0745896
chr1130269373026988E0746197
chr1130271013027156E0746361
chr1130310653031130E07410325
chr1130312013031261E07410461
chr1130317513031801E07411011
chr1130350633035174E07414323
chr1130418503041909E07421110
chr1130420223042072E07421282
chr1130422623042740E07421522
chr1130511793051219E07430439
chr1130513803051434E07430640
chr1130515143051804E07430774
chr1130518653052209E07431125
chr1130583013059394E07437561
chr1130629663063295E07442226
chr1130633203063649E07442580
chr1130637243064341E07442984
chr1130643523064467E07443612
chr1130644723064738E07443732
chr1130647903065068E07444050
chr1130651893065537E07444449
chr1130675333067642E07446793
chr1130701433070222E07449403
chr1130207813020831E08141
chr1130209853021035E081245
chr1130213433023046E081603
chr1130090683009383E082-11357
chr1130213433023046E082603










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr1130117713011832E067-8908
chr1130118583014423E067-6317
chr1130117713011832E068-8908
chr1130118583014423E068-6317
chr1130117713011832E069-8908
chr1130118583014423E069-6317
chr1130117713011832E070-8908
chr1130118583014423E070-6317
chr1130117713011832E071-8908
chr1130118583014423E071-6317
chr1130117713011832E072-8908
chr1130118583014423E072-6317
chr1130117713011832E073-8908
chr1130118583014423E073-6317
chr1130117713011832E074-8908
chr1130118583014423E074-6317
chr1130117713011832E081-8908
chr1130117713011832E082-8908
chr1130118583014423E082-6317